FFPE human pituitary sections stained with 100 ul anti-ACTH (clone SPM501) at 1:300. HIER epitope retrieval prior to staining was performed in 10mM Citrate, pH 6.0.
FFPE human pituitary sections stained with 100 ul anti-ACTH (clone SPM501) at 1:300. HIER epitope retrieval prior to staining was performed in 10mM Citrate, pH 6.0.Formalin-fixed, paraffin-embedded Human Pituitary stained with ACTH Monoclonal Antibody (SPM51).

Anti-ACTH Antibody Clone SPM501

$ 199.00$ 459.00
Please Select Product Options Below To View The Catalog Number.

SKU: 5443-MSM7X
Species: Human
Tested Applications: Immunohistochemistry (IHC)
Available Conjugates: Unconjugated
Isotype: Mouse IgG1
Mass Spec Validated?: Not MS Validated

Product NumberDescriptionPrice
5443-MSM7X-P0 Size: 20 ug, Tag: Unconjugated $ 199.00
5443-MSM7X-P1 Size: 100 ug, Tag: Unconjugated $ 429.00
5443-MSM7X-P2 Size: 200 ug, Tag: Unconjugated $ 459.00
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SKU: 5443-MSM7X-P0
ACTH General Information
Alternate Names
Pro-opiomelanocortin, POMC
Chromosomal Location
Curated Database and Bioinformatic Data
Gene SymbolPOMC
Entrez Gene ID5443
Ensemble Gene IDENSG00000115138
RefSeq Protein Accession(s)NP_001306134, NP_000930, NP_001030333, NP_001306133
RefSeq mRNA Accession(s)NM_001319204 NM_001035256, NM_001319205, NM_000939
RefSeq Genomic Accession(s)NG_008997, NC_000002, NC_018913
UniProt ID(s)P01189
UniGene ID(s)P01189
HGNC ID(s)9201
Cosmic ID(s)POMC
KEGG Gene ID(s)hsa:5443
PharmGKB ID(s)PA33526
General Description of ACTH.
ACTH (same as Corticotropin) is a 39 amino acid active peptide produced by the anterior pituitary. This MAb is specific to CLIP (aa25-39 of ACTH) ;does not react with Synacthen (aa1-24 of ACTH). POMC (pro-opiomelanocortin or corticotropin-lipotropin) is a 267 amino acid polypeptide hormone precursor that goes through extensive, tissue-specific posttranslational processing by convertases. POMC is cleaved into ten hormone chains named NPP, ACTH, alpha-MSH (Melanocyte Stimulating Hormone), beta-MSH, gamma-MSH, CLIP (corticotropin-like intermediary peptide), Lipotropin-beta, Lipotropin-gamma, beta-endorphin and Met-enkephalin. ACTH is also produced by cells of immune system (T-cells, B-cells, and macrophages) in response to stimuli associated with stress. Anti-ACTH is a useful marker in classification of pituitary tumors and the study of pituitary disease. It reacts with ACTH-producing cells (corticotrophs). It also may react with other tumors (e.g. some small cell carcinomas of the lung) causing paraneoplastic syndromes by secreting ACTH.

Human Anti-ACTH Antibody Product Attributes

Species: Human
Tested Applications: Immunohistochemistry (IHC).
Clonality: Monoclonal
Anti-ACTH Antibody Clone: SPM501
Clone SPM501 Host and Isotype: Mouse IgG1
Anti-Human ACTH Positive Control Sample: Normal pituitary gland or pituitary tumor
Cellular Localization of Antibody Cytoplasmic
Buffer and Stabilizer: 10mM PBS with 0.05% BSA and 0.05% Azide
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Synthetic peptide corresponding to aa25-39 of human ACTH (NGAEDESAEAFPLEF)
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.

ACTH Previously Observed Antibody Staining Patterns

Observed Antibody Staining Data By Tissue Type:

Variations in ACTH antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in cells in the anterior in pituitary gland. More moderate antibody staining intensity was present in cells in the anterior in pituitary gland. Low, but measureable presence of ACTH could be seen in. We were unable to detect ACTH in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.

Limitations and Warranty

enQuire Bio's ACTH Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

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Anti-ACTH Antibody Clone SPM501

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