Antibody (Suitable for clinical applications)
Sample Type: FFPE Patient Samples.
Tested Applications: IHC. Approved for In Vitro Diagnostic Procedures on FFPE tissues. For tissue collection recommendations, please see datasheet sent with product.
|Recommended Dilution (Conc)
||No Pretreatment Required
||30 min at Room Temperature
Prior to use, inspect vial for the presence of any precipitate or other unusual physical properties. These can indicate that the antibody has degraded and is no longer suitable for patient samples. Please run positive and negative controls simultaneously with all patient samples to account and control for errors in laboratory procedure. Use of methods or materials not recommended by enQuire Bio including change to dilution range and detection system should be routinely validated by the user.
Anti-ACTH Antibody Clone: AH26
Host and Isotype: Mouse IgG1
Recommended Positive Control Sample: Pituitary
Cellular Localization of Antibody AH26 Staining: Cytoplasmic
Buffer and Stabilizer: PBS with 1% BSA and 0.05% NaN3
Lot specific. Plese contact tech support
Immunogen: BALB/C mice were injected with a synthetic peptide corresponding to amino acids 1-24 from the N-terminal of human ACTH.
Storage Conditions: This antibody should be stored refrigerated (2-8°C). This product should not be used past the expiration date printed on the vial.
ACTH Information for Pathologists
Adrenocorticotrophic hormone (ACTH) is a peptide hormone secreted from the anterior pituitary gland that stimulates the adrenal cortex to secrete glucocorticoid hormones. The hormone comprises a long chain of amino acids that share a high degree of homology between humans, cows, pigs and sheep. Mature ACTH is derived from POMC cleavage in response to CRH release from the hypothalamus.
Common Uses By Pathologists:
ACTH immunostaining is useful for classifying pituitary tumors and other pituitary disease. It reacts with corticotrophs (cells that produce ACTH) including some small-cell carcinomas present in lung tissue which cause Paraneoplastic Syndromes.
Limitations and Warranty
This antibody is manufactured in accordance with clinical good manufacturing practices in an ISO13485:2016 certified production facility. It is intended for multiple uses including in vitro diagnostic use and research use only applications. Please see vial label for expiration date. We strive to always deliver antibodies with a shelf life of at least two years.