Human Anti-Alpha-1-Antichymotrypsin Antibody Product Attributes
Species: Human
Tested Applications: Immunohistochemistry (IHC).
Clonality: Monoclonal
Anti-Alpha-1-Antichymotrypsin Antibody Clone: AACT/1451
Clone AACT/1451 Host and Isotype: Mouse IgG1
Anti-Human Alpha-1-Antichymotrypsin Positive Control Sample: HeLa Cells. Tonsil, Pancreas or Histiocytoma.
Cellular Localization of Antibody Cytoplasmic
Buffer and Stabilizer: 10mM PBS with 0.05% BSA and 0.05% Azide
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Recombinant human Antichymotrypsin (AACT) protein fragment (aa49-187)
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.
Alpha-1-Antichymotrypsin Previously Observed Antibody Staining Patterns
Observed Antibody Staining Data By Tissue Type:
Variations in Alpha-1-Antichymotrypsin antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. Low, but measureable presence of Alpha-1-Antichymotrypsin could be seen inglandular cells in the adrenal gland, breast, cervix, uterine and epididymis, cells in the tubules in kidney, hepatocytes in liver, exocrine glandular cells in the pancreas, glandular cells in the parathyroid gland and seminal vesicle, cells in the seminiferous ducts in testis, Leydig cells in the testis, urothelial cells in the urinary bladder, hematopoietic cells in the bone marrow, glandular cells in the breast, glial cells in the cerebral cortex, glandular cells in the cervix, uterine and gallbladder, myocytes in heart muscle, cells in the tubules in kidney, hepatocytes in liver, germinal center cells in the lymph node, non-germinal center cells in the lymph node, exocrine glandular cells in the pancreas, glandular cells in the parathyroid gland and prostate, smooth muscle cells in the smooth muscle, adipocytes in mesenchymal tissue, Leydig cells in the testis, glandular cells in the adrenal gland, breast and cervix and uterine and epididymis. We were unable to detect Alpha-1-Antichymotrypsin in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.Observed Antibody Staining Data By Tissue Disease Status:
Tissues from cancer patients, for instance, have their own distinct pattern of Alpha-1-Antichymotrypsin expression as measured by anti-Alpha-1-Antichymotrypsin antibody immunohistochemical staining. The average level of expression by tumor is summarized in the table below. The variability row represents patient to patient variability in IHC staining.| Sample Type | breast cancer | carcinoid | cervical cancer | colorectal cancer | endometrial cancer | glioma | head and neck cancer | liver cancer | lung cancer | lymphoma | melanoma | ovarian cancer | pancreatic cancer | prostate cancer | renal cancer | skin cancer | stomach cancer | testicular cancer | thyroid cancer | urothelial cancer |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal Intensity | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| SERPINA3 Variability | ++ | ++ | + | + | + | + | ++ | ++ | + | + | + | + | + | ++ | + | + | + | + | + | + |
Limitations and Warranty
enQuire Bio's Alpha-1-Antichymotrypsin Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.
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