Formalin-fixed, paraffin-embedded human Tonsil stained with Alpha-1-Antitrypsin Monoclonal Antibody (AAT/1379)
Formalin-fixed, paraffin-embedded human Tonsil stained with Alpha-1-Antitrypsin Monoclonal Antibody (AAT/1379)

Anti-Alpha-1-Antitrypsin Antibody Clone AAT/1379

$ 199.00$ 459.00
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SKU: 5265-MSM2
Species: Human
Tested Applications: Immunohistochemistry (IHC)
Available Conjugates: Unconjugated
Isotype: Mouse IgG1
Mass Spec Validated?: Not MS Validated

Product NumberDescriptionPrice
5265-MSM2-P0 Size: 20 ug, Tag: Unconjugated $ 199.00
5265-MSM2-P1 Size: 100 ug, Tag: Unconjugated $ 429.00
5265-MSM2-P2 Size: 200 ug, Tag: Unconjugated $ 459.00
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In Stock.
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SKU: 5265-MSM2-P0
Alpha-1-Antitrypsin General Information
Alternate Names
A1AT, AAT, Alpha 1 antiproteinase Alpha 1-antitrypsin, Alpha-1 protease inhibitor, Serine protease inhibitor 1-1, Serine protease inhibitor A1a, Serpina1
Molecular Weight
Chromosomal Location
Curated Database and Bioinformatic Data
Gene SymbolSERPINA1
Entrez Gene ID5265
Ensemble Gene IDENSG00000277377, ENSG00000197249
RefSeq Protein Accession(s)NP_001121174, XP_016876859, NP_001121172, NP_001121177, NP_001002236, NP_001121178, NP_001002235, NP_001121179, NP_000286, NP_001121175, NP_001121176, NP_001121173
RefSeq mRNA Accession(s)NM_000295, NM_001127707, NM_001127701, NM_001002235 NM_001002236, NM_001127702, NM_001127706, XM_017021370, NM_001127700, NM_001127703, NM_001127704, NM_001127705
RefSeq Genomic Accession(s)NC_000014, NG_008290, NC_018925, NG_187601
UniProt ID(s)E9KL23, P01009
UniGene ID(s)E9KL23, P01009
HGNC ID(s)8941
Cosmic ID(s)SERPINA1
KEGG Gene ID(s)hsa:5265
PharmGKB ID(s)PA35509
General Description of Alpha-1-Antitrypsin.
The immunohistochemical staining of AAT is useful in identification of benign and malignant hepatic tumors and yolk sac carcinomas. Positive staining for AAT is also used in detection of benign and malignant lesions of histiocytic nature. This antibody is may also useful tool in the screening of patients with cryptogenic cirrhosis or other forms of liver disease with fibrosis of uncertain origin.

Human Anti-Alpha-1-Antitrypsin Antibody Product Attributes

Species: Human
Tested Applications: Immunohistochemistry (IHC).
Clonality: Monoclonal
Anti-Alpha-1-Antitrypsin Antibody Clone: AAT/1379
Clone AAT/1379 Host and Isotype: Mouse IgG1
Anti-Human Alpha-1-Antitrypsin Positive Control Sample: HepG2 Cells. Tonsil, Hepatocellular Carcinoma or Histiocytoma.
Cellular Localization of Antibody Cytoplasmic
Buffer and Stabilizer: 10mM PBS with 0.05% BSA and 0.05% Azide
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Recombinant human Alpha-1-Antitrypsin (AAT) protein fragment
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.

Alpha-1-Antitrypsin Previously Observed Antibody Staining Patterns

Observed Subcellular, Organelle Specific Staining Data:

Anti-serpina1 antibody staining is expected to be primarily localized to the vesicles.

Observed Antibody Staining Data By Tissue Type:

Variations in Alpha-1-Antitrypsin antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. Low, but measureable presence of Alpha-1-Antitrypsin could be seen inglandular cells in the cervix, uterine, hepatocytes in liver, trophoblastic cells in the placenta, glandular cells in the seminal vesicle, smooth muscle cells in the smooth muscle, adipocytes in mesenchymal tissue, cells in the seminiferous ducts in testis and squamous epithelial cells in the tonsil. We were unable to detect Alpha-1-Antitrypsin in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.

Limitations and Warranty

enQuire Bio's Alpha-1-Antitrypsin Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

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Anti-Alpha-1-Antitrypsin Antibody Clone AAT/1379