Formalin-fixed, paraffin-embedded human Prostate Carcinoma  Stained with AMACR / p54S Monoclonal Antibody (AMACR/1723)
Formalin-fixed, paraffin-embedded human Prostate Carcinoma  Stained with AMACR / p54S Monoclonal Antibody (AMACR/1723)

Anti-AMACR / p504S Antibody Clone AMACR/1723

$ 118.00$ 418.00
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SKU: 23600-MSM3
Species: Human
Tested Applications: Immunohistochemistry (IHC)
Available Conjugates: Unconjugated
Isotype: Mouse IgG
Mass Spec Validated?: Not MS Validated

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Datasheets and Documentation
Product Datasheet
SKU: 23600-MSM3-P0
AMACR / p504S General Information
Alternate Names
alpha-methylacyl-CoA racemase, AMACR
Molecular Weight
54kDa
Chromosomal Location
5p13.3
Curated Database and Bioinformatic Data
Gene SymbolAMACR
Entrez Gene ID23600
Ensemble Gene IDENSG00000242110
RefSeq Protein Accession(s)NP_055139, NP_976316, NP_001161067
RefSeq mRNA Accession(s)NM_203382, NM_001167596, NM_001167598, NM_001167595, NM_001167597, NM_014324
RefSeq Genomic Accession(s)NG_016211, NC_000005, NC_018916
UniProt ID(s)Q9UHK6
UniGene ID(s)Q9UHK6
HGNC ID(s)451
Cosmic ID(s)AMACR
KEGG Gene ID(s)hsa:23600
PharmGKB ID(s)PA24757
General Description of AMACR / p504S.
This antibody recognizes a protein of 54kDa, which is identified as AMACR, also known as p504S. It is an enzyme that is involved in bile acid biosynthesis and ?-oxidation of branched-chain fatty acids. AMACR is essential in lipid metabolism. It is expressed in cells of premalignant high-grade prostatic intraepithelial neoplasia (HGPIN) and prostate adenocarcinoma. The majority of the carcinoma cells show a distinct granular cytoplasmic staining reaction. AMACR is present at low or undetectable levels in glandular epithelial cells of normal prostate and benign prostatic hyperplasia. A spotty granular cytoplasmic staining is seen in a few cells of the benign glands. AMACR is expressed in normal liver (hepatocytes), kidney (tubular epithelial cells) and gall bladder (epithelial cells). Expression has also been found in lung (bronchial epithelial cells) and colon (colonic surface epithelium). AMACR expression can also be found in hepatocellular carcinoma and kidney carcinoma. Past studies have also shown that AMACR is expressed in various colon carcinomas (well, moderately and poorly differentiated) and over expressed in prostate carcinoma.

Human Anti-AMACR / p504S Antibody Product Attributes

Species: Human
Tested Applications: Immunohistochemistry (IHC).
Clonality: Monoclonal
Anti-AMACR / p504S Antibody Clone: AMACR/1723
Clone AMACR/1723 Host and Isotype: Mouse IgG
Anti-Human AMACR / p504S Positive Control Sample: HEK cells or Prostate Adenocarcinoma
Cellular Localization of Antibody Cytoplasmic
Buffer and Stabilizer: 10mM PBS with 0.05% BSA and 0.05% Azide
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Recombinant human full-length AMACR protein
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.

AMACR / p504S Previously Observed Antibody Staining Patterns

Observed Subcellular, Organelle Specific Staining Data:

Anti-AMACR antibody staining is expected to be primarily localized to the vesicles and plasma membrane.

Observed Antibody Staining Data By Tissue Type:

Variations in AMACR / p504S antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in cells in the tubules in kidney. More moderate antibody staining intensity was present in cells in the tubules in kidney. Low, but measureable presence of AMACR / p504S could be seen in cells in the seminiferous ducts in testis, epidermal cells in the skin, glandular cells in the adrenal gland, appendix, cervix, uterine, duodenum, endometrium, epididymis, fallopian tube, gallbladder, prostate, salivary gland, small intestine and stomach, islets of Langerhans in pancreas, macrophages in lung, neuronal cells in the cerebral cortex and hippocampus, Purkinje cells in the cerebellum and respiratory epithelial cells in the bronchus and nasopharynx. We were unable to detect AMACR / p504S in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.

Limitations and Warranty

enQuire Bio's AMACR / p504S Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

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