Immunohistochemical staining of Amyloid A Component  of human FFPE tissue followed by incubation with HRP labeled secondary and development with DAB substrate.

Amyloid A Component [mcl] Antibody (cGMP).

$ 128.00$ 408.00
Please Select Product Options Below To View The Catalog Number.

SKU: QIVD70
Species: Human
Tested Applications: IHC [IVD]
Available Conjugates:
Isotype: Mouse IgG2a, kappa

Product NumberDescriptionPrice
QIVD70-0.1ml Size: 0.1 ml, Format: Concentrate $ 128.00
QIVD70-0.5ml Size: 0.5 ml, Format: Concentrate $ 248.00
QIVD70-1ml Size: 1 ml, Format: Concentrate $ 408.00
QIVD70-6ml Size: 6 ml, Format: Predilute $ 198.00
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Datasheets and Documentation
Product Datasheet
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SKU: QIVD70-0.1ml
Amyloid A Component General Information
Alternate Names
Molecular Weight
13.5 kDa
Chromosomal Location
p15.1 [chr: 11] [chr_start: 18266260] [chr_end: 18269977] [strand: 1]
Curated Database and Bioinformatic Data
Gene SymbolSAA1
Entrez Gene ID6288
RefSeq Protein Accession(s)NP_000322; NP_001171477; NP_954630
RefSeq mRNA Accession(s); NM_001178006; NM_000331; NM_199161
RefSeq Genomic Accession(s)NG_021330; NW_021160006; NC_000011
UniProt ID(s)P0DJI8
KEGG Gene ID(s)hsa:6288
Associated Diseases (KEGG IDs)Reactive, secondary amyloidosis is characterized by the extracellular accumulation in various tissues of the SAA1 protein. These deposits are highly insoluble and resistant to proteolysis; they disrupt tissue structure and compromise function. {ECO:0000269|PubMed:1463770}.; Elevated serum SAA1 protein levels may be associated with lung cancer. {ECO:0000269|PubMed:1463770}.
General Description of Amyloid A Component .
This antibody reacts with amyloid deposits in all organs and tissues. It reacts specifically with amyloid A protein in the native fibrils as well as fixed fibrils but does not show any reactivity with non-amyloid A fibril protein.

Antibody (Suitable for clinical applications)

Sample Type: FFPE Patient Samples.
Tested Applications: IHC. Approved for In Vitro Diagnostic Procedures on FFPE tissues. For tissue collection recommendations, please see datasheet sent with product.
Application Notes
Specification Recommendation
Recommended Dilution (Conc) 1:10-1:25
Pretreatment Citrate Buffer pH 6.0
Incubation Parameters 30 min at Room Temperature

Prior to use, inspect vial for the presence of any precipitate or other unusual physical properties. These can indicate that the antibody has degraded and is no longer suitable for patient samples. Please run positive and negative controls simultaneously with all patient samples to account and control for errors in laboratory procedure. Use of methods or materials not recommended by enQuire Bio including change to dilution range and detection system should be routinely validated by the user.

Clonality: Monoclonal
Anti-Amyloid A Component Antibody Clone: mcl
Host and Isotype: Mouse IgG2a, kappa
Recommended Positive Control Sample: Kidney
Cellular Localization of Antibody mcl Staining: Extracellular
Buffer and Stabilizer: PBS with 1% BSA and 0.05% NaN3
Antibody Concentration: Lot specific. Plese contact tech support for data.
Immunogen: Human amyloid A protein coupled to horseradish peroxidase and kininogen.
Storage Conditions: This antibody should be stored refrigerated (2-8°C). This product should not be used past the expiration date printed on the vial.

Amyloid A Component Information for Pathologists

Summary:

Acute phase protein, which has diagnostic, therapeutic and prognostic implications in a wide variety of diseases. First recognized in serum with its cross reactivity with antisera to amyloid AA of secondary amyloid; both proteins have precursor / product relationship. Synthesized in liver.

Common Uses By Pathologists:

Circulating SAA is associated with prognosis in osteosarcoma patients (Pediatr Blood Cancer 2017 May 24 [Epub ahead of print]). Serum level of SAA is upregulated in glioblastoma (J Neurooncol 2017;132:383). SAA staining is fairly specific for sarcoidosis (Respir Med 2017;126:1). It is associated with earlier stages of chronic hepatitis (Histopathology 2016;69:937) and can be used in combination with other markers to classify hepatocellular adenoma into groups (Front Med (Lausanne) 2017;4:10).

Limitations and Warranty

This antibody is manufactured in accordance with clinical good manufacturing practices in an ISO13485:2016 certified production facility. It is intended for multiple uses including in vitro diagnostic use and research use only applications. Please see vial label for expiration date. We strive to always deliver antibodies with a shelf life of at least two years.

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Amyloid A Component [mcl] Antibody (cGMP).