FFPE human prostate carcinoma sections stained with 100 ul anti-Androgen Receptor (clone AR441 + DHTR/882) at 1:50. HIER epitope retrieval prior to staining was performed in 10mM Tris 1mM EDTA, pH 9.0.

Formalin-fixed, paraffin-embedded human prostate carcinoma stained with Androgen Receptor Monoclonal Antibody (AR441 + DHTR/882).

Anti-Androgen Receptor Antibody Clone AR441 + DHTR/882

Name: Anti-Androgen Receptor Antibody Clone AR441 + DHTR/882
Brand: enQuire Bio
Price: 488 USD
Availability: InStock

$ 429.00

Please Select Product Options Below To View The Catalog Number.

SKU: 367-MSM3
Species: Human and Mouse (-)
Tested Applications: Immunofluorescence, Immunohistochemistry (IHC)
Available Conjugates: Unconjugated
Isotype: Mouse IgG
Mass Spec Validated?: Not MS Validated

Product Number	Description	Price
367-MSM3-P1	Size: 100 ug, Tag: Unconjugated

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Datasheets and Documentation

Product Datasheet

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SKU: 367-MSM3-P1

Androgen Receptor General Information
Alternate Names
AR, Androgen Receptor, NR3C4
Molecular Weight
110kDa
Chromosomal Location
Xq12
Curated Database and Bioinformatic Data
Gene Symbol	AR
Entrez Gene ID	367
Ensemble Gene ID	ENSG00000169083
RefSeq Protein Accession(s)	NP_000035, NP_001334992, NP_001334993, NP_001011645, NP_001334990
RefSeq mRNA Accession(s)	NM_001348063, NM_001348064 NM_001011645, NM_001348061, NM_000044
RefSeq Genomic Accession(s)	NC_018934, NG_009014, NC_000023
UniProt ID(s)	F1D8N5, A0A087WUX9, G4VV16, Q9NUA2, P10275
UniGene ID(s)	F1D8N5, A0A087WUX9, G4VV16, Q9NUA2, P10275
HGNC ID(s)	644
Cosmic ID(s)	AR
KEGG Gene ID(s)	hsa:367
PharmGKB ID(s)	PA57
General Description of Androgen Receptor.
Recognizes a protein of 110kDa, which is identified as,rogen receptor (AR). It reacts with full length,, the newly described A form of the receptor. It does not cross react with estrogen, progesterone, or glucocorticoid receptors. The expression of AR is reportedly inversely correlated with histologic grade i.e. well differentiated prostate tumors show higher expression than the poorly differentiated tumors. In prostate cancer, AR has been proposed, as a marker of hormone-responsiveness, thus it may be useful in identifying patients likely to benefit from anti-androgen therapy. Anti-androgen receptor has been useful clinically in differentiating morpheaform basal cell carcinoma (mBCC) from desmoplastic trichoepithelioma (DTE) in the skin.This MAb is superb for staining of formalin/paraffin tissues.

Human and Mouse (-) Anti-Androgen Receptor Antibody Product Attributes

Species: Human and Mouse (-)

Tested Applications: Immunofluorescence, Immunohistochemistry (IHC).

Application Notes: Immunofluorescence (0.5-1ug of antibody/ml), Immunohistochemistry (IHC) (Formalin-fixed) (0.5-1ug of antibody/ml for 30 minutes at RT)

Clonality: Monoclonal

Anti-Androgen Receptor Antibody Clone: AR441 + DHTR/882

Clone AR441 + DHTR/882 Host and Isotype: Mouse IgG

Anti-Human and Mouse (-) Androgen Receptor Positive Control Sample: LNCap cells or Prostate carcinoma

Cellular Localization of Antibody Nuclear

Buffer and Stabilizer: 1mM PBS with 0.05% BSA & 0.05% azide.

Antibody Concentration: 200ug/ml

Antibody Purification Method:Protein A/G Purified

Immunogen: A synthetic peptide, aa 299-315, (STEDTAEYSPFKGGYTK) of human AR (AR441); Recombinant human DHTR protein (DHTR/882)

Storage Conditions: Store at 2 to 8Â° C (refrigerate). Stable for 24 months when properly stored.

Androgen Receptor Previously Observed Antibody Staining Patterns

Observed Subcellular, Organelle Specific Staining Data:

Anti-ar antibody staining is expected to be primarily localized to the mitochondria.

Observed Antibody Staining Data By Tissue Type:

Variations in Androgen Receptor antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in glandular cells in the epididymis, seminal vesicle. More moderate antibody staining intensity was present in glandular cells in the epididymis, seminal vesicle. Low, but measureable presence of Androgen Receptor could be seen inglandular cells in the cervix, uterine. We were unable to detect Androgen Receptor in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.

Observed Antibody Staining Data By Tissue Disease Status:

Tissues from cancer patients, for instance, have their own distinct pattern of Androgen Receptor expression as measured by anti-Androgen Receptor antibody immunohistochemical staining. The average level of expression by tumor is summarized in the table below. The variability row represents patient to patient variability in IHC staining.

Sample Type	breast cancer	carcinoid	cervical cancer	colorectal cancer	endometrial cancer	glioma	head and neck cancer	liver cancer	lung cancer	lymphoma	melanoma	ovarian cancer	pancreatic cancer	prostate cancer	renal cancer	skin cancer	stomach cancer	testicular cancer	thyroid cancer	urothelial cancer
Signal Intensity	++	-	-	-	-	-	-	-	-	-	-	-	-	+++	-	-	-	-	-	-
AR Variability	++	+	+	+	++	+	++	+	+	+	+	++	+	+	+	++	+	+	+	+

Limitations and Warranty

enQuire Bio's Androgen Receptor Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

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