Formalin-fixed, paraffin-embedded human prostate carcinoma stained with Androgen Receptor Monoclonal Antibody (AR441 + DHTR/882).
Formalin-fixed, paraffin-embedded human prostate carcinoma stained with Androgen Receptor Monoclonal Antibody (AR441 + DHTR/882).

Anti-Androgen Receptor Antibody Clone AR441 + DHTR/882

$ 298.00
Please Select Product Options Below To View The Catalog Number.

SKU: 367-MSM3
Species: Human and Mouse (-)
Tested Applications: Immunofluorescence, Immunohistochemistry (IHC)
Available Conjugates: Unconjugated
Isotype: Mouse IgG
Mass Spec Validated?: Not MS Validated

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Datasheets and Documentation
Product Datasheet
SKU: 367-MSM3-P1
Androgen Receptor General Information
Alternate Names
AR, Androgen Receptor, NR3C4
Molecular Weight
110kDa
Chromosomal Location
Xq12
Curated Database and Bioinformatic Data
Gene SymbolAR
Entrez Gene ID367
Ensemble Gene IDENSG00000169083
RefSeq Protein Accession(s)NP_000035, NP_001334992, NP_001334993, NP_001011645, NP_001334990
RefSeq mRNA Accession(s)NM_001348063, NM_001348064 NM_001011645, NM_001348061, NM_000044
RefSeq Genomic Accession(s)NC_018934, NG_009014, NC_000023
UniProt ID(s)F1D8N5, A0A087WUX9, G4VV16, Q9NUA2, P10275
UniGene ID(s)F1D8N5, A0A087WUX9, G4VV16, Q9NUA2, P10275
HGNC ID(s)644
Cosmic ID(s)AR
KEGG Gene ID(s)hsa:367
PharmGKB ID(s)PA57
General Description of Androgen Receptor.
Recognizes a protein of 110kDa, which is identified as,rogen receptor (AR). It reacts with full length,, the newly described A form of the receptor. It does not cross react with estrogen, progesterone, or glucocorticoid receptors. The expression of AR is reportedly inversely correlated with histologic grade i.e. well differentiated prostate tumors show higher expression than the poorly differentiated tumors. In prostate cancer, AR has been proposed, as a marker of hormone-responsiveness, thus it may be useful in identifying patients likely to benefit from anti-androgen therapy. Anti-androgen receptor has been useful clinically in differentiating morpheaform basal cell carcinoma (mBCC) from desmoplastic trichoepithelioma (DTE) in the skin.This MAb is superb for staining of formalin/paraffin tissues.

Human and Mouse (-) Anti-Androgen Receptor Antibody Product Attributes

Species: Human and Mouse (-)
Tested Applications: Immunofluorescence, Immunohistochemistry (IHC).
Application Notes: Immunofluorescence (0.5-1ug of antibody/ml), Immunohistochemistry (IHC) (Formalin-fixed) (0.5-1ug of antibody/ml for 30 minutes at RT)
Clonality: Monoclonal
Anti-Androgen Receptor Antibody Clone: AR441 + DHTR/882
Clone AR441 + DHTR/882 Host and Isotype: Mouse IgG
Anti-Human and Mouse (-) Androgen Receptor Positive Control Sample: LNCap cells or Prostate carcinoma
Cellular Localization of Antibody Nuclear
Buffer and Stabilizer: 1mM PBS with 0.05% BSA & 0.05% azide.
Antibody Concentration: 200ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: A synthetic peptide, aa 299-315, (STEDTAEYSPFKGGYTK) of human AR (AR441); Recombinant human DHTR protein (DHTR/882)
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.

Androgen Receptor Previously Observed Antibody Staining Patterns

Observed Subcellular, Organelle Specific Staining Data:

Anti-ar antibody staining is expected to be primarily localized to the mitochondria.

Observed Antibody Staining Data By Tissue Type:

Variations in Androgen Receptor antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in glandular cells in the epididymis, seminal vesicle. More moderate antibody staining intensity was present in glandular cells in the epididymis, seminal vesicle. Low, but measureable presence of Androgen Receptor could be seen inglandular cells in the cervix, uterine. We were unable to detect Androgen Receptor in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.

Observed Antibody Staining Data By Tissue Disease Status:

Tissues from cancer patients, for instance, have their own distinct pattern of Androgen Receptor expression as measured by anti-Androgen Receptor antibody immunohistochemical staining. The average level of expression by tumor is summarized in the table below. The variability row represents patient to patient variability in IHC staining.

Sample Type breast cancer carcinoid cervical cancer colorectal cancer endometrial cancer glioma head and neck cancer liver cancer lung cancer lymphoma melanoma ovarian cancer pancreatic cancer prostate cancer renal cancer skin cancer stomach cancer testicular cancer thyroid cancer urothelial cancer
Signal Intensity ++ - - - - - - - - - - - - +++ - - - - - -
AR Variability ++ + + + ++ + ++ + + + + ++ + + + ++ + + + +

Limitations and Warranty

enQuire Bio's Androgen Receptor Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

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