C57Bl/6 splenocytes were stimulated for 3 days with ConA and stained with FITC Mouse Anti-CD4  followed by intracellular staining with 0.06 ug APC Mouse Anti-CD152 (QAB58) (right) or 0.06 ug APC Armenian Hamster isotype control (left).

Mouse Anti-CD152 / CTLA-4 Antibody [UC10-4F10-11]

$ 49.00$ 229.00
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Species: Mouse
Tested Applications: Flow Cytometry
Available Conjugates: PE ;Unconjugated ;APC ;PE-Cy7
Isotype: Armenian Hamster IgG
Mass Spec Validated?: Not MS Validated

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Datasheets and Documentation
Product Datasheet
SKU: QAB58-PE-25ug
Anti-CD152 General Information
Alternate Names
Curated Database and Bioinformatic Data
Gene SymbolCtla4
Entrez Gene ID12477
Ensemble Gene IDENSMUSG00000026011, ENSMUSG00000103326
RefSeq Protein Accession(s)NP_033973, NP_001268905
RefSeq mRNA Accession(s)NM_001281976, NM_009843
RefSeq Genomic Accession(s)NW_006763128, NG_187019, NC_000067
UniProt ID(s)Q5SSM0, P09793, Q6GTR6
UniGene ID(s)Q5SSM0, P09793, Q6GTR6
Cosmic ID(s)Ctla4
KEGG Gene ID(s)mmu:12477
General Description of Anti-CD152.
The UC10-4F10-11 antibody is specific for mouse CD152, commonly known as CTLA-4, a 33-37 kDa protein expressed as a homodimer on the surface of activated T and B cells, and on thymocytes. CTLA-4 is structurally similar, yet functionally disparate, to the T cell co-stimulatory molecule CD28. Both CTLA-4 and CD28 interact with the co-stimulatory molecules CD80 (B7-1) and CD86 (B7-2) on antigen-presenting cells, with CTLA-4 displaying a higher avidity than CD28. While CD28 typically delivers a potent co-stimulatory signal in support of T cell activation, CTLA-4 appears to act as a negative regulator of T cell activation and may contribute to the suppressor function of Treg cells.CTLA-4 proteins may be initially sequestered within Golgi vesicles, from which they can be rapidly transferred to and from the cell surface, a mechanism by which Treg cells can selectively impart suppressive functions. The UC10-4F10-11 antibody may be used for flow cytometric analysis of CTLA-4 expression.

Mouse Anti-Anti-CD152 Antibody Product Attributes

Species: Mouse
Tested Applications: Flow Cytometry.
Application Notes: See Product Datasheet for Recommended Dilution Range. Requires Experimental Optimization
Clonality: Monoclonal Antibody
Anti-Anti-CD152 Antibody Clone: UC10-4F10-11
Clone UC10-4F10-11 Host and Isotype: Armenian Hamster IgG
Buffer and Stabilizer: 10 mM NaH2PO4, 150 mM NaCl, 0.09% NaN3, 0.1% gelatin, pH7.2
Antibody Concentration: 0.2 mg/mL
Storage Conditions: 2-8C protected from light. Stable for 12 Months. Do Not Freeze.

Anti-CD152 Previously Observed Antibody Staining Patterns

Selected References

Lischke T, Hegemann A, Gurka S, Van DV, Burmeister Y, Lam K-P, Kershaw O, Mollenkopf H-J, Mages HW, Hutloff A, and Kroczek RA. 2012. J. Immunol. 189: 234-244. (Flow Cytometry). Tai X, Laethem FV, Pobezinsky L, Guinter T, Sharrow SO, Adams A, Granger L, Kruhlak M, Lindsten T, Thompson CB, Feigenbaum L, and Singer A. 2012. 119: 5155-5163. (Flow Cytometry). Matheu MP, Su Y, Greenberg ML, Blanc CA, Parker I, Scott DW, and Calahan MD. 2012. 109: E1258-E1266. (in vitro blocking).

Limitations and Warranty

enQuire Bio's Mouse Anti-CD152 / CTLA-4 Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

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