C57Bl/6 splenocytes were stimulated for 3 days with ConA and stained with FITC Mouse Anti-CD4  followed by intracellular staining with 0.06 ug APC Mouse Anti-CD152 (QAB58) (right) or 0.06 ug APC Armenian Hamster isotype control (left).
C57Bl/6 splenocytes were stimulated for 3 days with ConA and stained with FITC Mouse Anti-CD4  followed by intracellular staining with 0.06 ug APC Mouse Anti-CD152 (QAB58) (right) or 0.06 ug APC Armenian Hamster isotype control (left).C57Bl/6 splenocytes were stimulated for 3 days with ConA and stained with APC Mouse Anti-CD4  followed by intracellular staining with 0.125 ug PE-Cy7 Mouse Anti-CD152 .C57Bl/6 splenocytes were stimulated for 3 days with ConA and stained with FITC Mouse Anti-CD4  followed by intracellular staining with 0.06 ug APC Mouse Anti-CD152 (QAB58) (right) or 0.06 ug APC Armenian Hamster isotype control (left).C57Bl/6 splenocytes were stimulated for 3 days with ConA and stained with APC Mouse Anti-CD4  followed by intracellular staining with 0.125 ug PE-Cy7 Mouse Anti-CD152 .

Anti-CD152 / CTLA-4 Antibody [UC10-4F10-11]

$ 48.00$ 208.00
Please Select Product Options Below To View The Catalog Number.

SKU: QAB58
Species: Mouse
Tested Applications: Flow Cytometry
Available Conjugates: PE ;Unconjugated ;APC ;PE-Cy7
Isotype: Armenian Hamster IgG
Mass Spec Validated?: Not MS Validated

Size
Tag Clear selection
Shipping Information
In Stock: 1-2 Day Lead Time.
Flat Rate Shipping Anywhere in the US: $45
Datasheets and Documentation
Product Datasheet
SKU: QAB58-PE-25ug
Anti-CD152 General Information
Alternate Names
CTLA4, CD152, CTLA-4, ALPS5, GRD4, CD, CD152, IDDM12, GSE, CELIAC3
Curated Database and Bioinformatic Data
Gene SymbolCtla4
Entrez Gene ID12477
Ensemble Gene IDENSMUSG00000026011, ENSMUSG00000103326
RefSeq Protein Accession(s)NP_033973, NP_001268905
RefSeq mRNA Accession(s)NM_001281976, NM_009843
RefSeq Genomic Accession(s)NW_006763128, NG_187019, NC_000067
UniProt ID(s)Q5SSM0, P09793, Q6GTR6
UniGene ID(s)Q5SSM0, P09793, Q6GTR6
Cosmic ID(s)Ctla4
KEGG Gene ID(s)mmu:12477
General Description of Anti-CD152.
The UC10-4F10-11 antibody is specific for mouse CD152, commonly known as CTLA-4, a 33-37 kDa protein expressed as a homodimer on the surface of activated T and B cells, and on thymocytes. CTLA-4 is structurally similar, yet functionally disparate, to the T cell co-stimulatory molecule CD28. Both CTLA-4 and CD28 interact with the co-stimulatory molecules CD80 (B7-1) and CD86 (B7-2) on antigen-presenting cells, with CTLA-4 displaying a higher avidity than CD28. While CD28 typically delivers a potent co-stimulatory signal in support of T cell activation, CTLA-4 appears to act as a negative regulator of T cell activation and may contribute to the suppressor function of Treg cells.CTLA-4 proteins may be initially sequestered within Golgi vesicles, from which they can be rapidly transferred to and from the cell surface, a mechanism by which Treg cells can selectively impart suppressive functions. The UC10-4F10-11 antibody may be used for flow cytometric analysis of CTLA-4 expression.

Mouse Anti-Anti-CD152 Antibody Product Attributes

Species: Mouse
Tested Applications: Flow Cytometry.
Application Notes: See Product Datasheet for Recommended Dilution Range. Requires Experimental Optimization
Clonality: Monoclonal Antibody
Anti-Anti-CD152 Antibody Clone: UC10-4F10-11
Clone UC10-4F10-11 Host and Isotype: Armenian Hamster IgG
Buffer and Stabilizer: 10 mM NaH2PO4, 150 mM NaCl, 0.09% NaN3, 0.1% gelatin, pH7.2
Antibody Concentration: 0.2 mg/mL
Storage Conditions: 2-8C protected from light. Stable for 12 Months. Do Not Freeze.

Anti-CD152 Previously Observed Antibody Staining Patterns

Selected References

Lischke T, Hegemann A, Gurka S, Van DV, Burmeister Y, Lam K-P, Kershaw O, Mollenkopf H-J, Mages HW, Hutloff A, and Kroczek RA. 2012. J. Immunol. 189: 234-244. (Flow Cytometry). Tai X, Laethem FV, Pobezinsky L, Guinter T, Sharrow SO, Adams A, Granger L, Kruhlak M, Lindsten T, Thompson CB, Feigenbaum L, and Singer A. 2012. 119: 5155-5163. (Flow Cytometry). Matheu MP, Su Y, Greenberg ML, Blanc CA, Parker I, Scott DW, and Calahan MD. 2012. 109: E1258-E1266. (in vitro blocking).

Limitations and Warranty

enQuire Bio's Mouse Anti-CD152 / CTLA-4 Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

There are no reviews yet.

Be the first to review “Anti-CD152 / CTLA-4 Antibody [UC10-4F10-11]”

Your email address will not be published. Required fields are marked *

Share a Protocol (View Reviewed Protocols Below)

Protocol Title

Materials

Methods

Notes


  protocol submission gif

enQuire Bio, LLC   1825 Lawrence St, Ste 115   Denver, CO 80202
Phone: 1-855-344-1400 | enquire@enquirebio.com | Fax: 1-720-897-3730
Customer Service Available M-F 8AM-6PM MST or 24/7 Via Email
Scroll to top

We consume cookies ensure that we give you the best experience on our website. If you continue to use this site we will assume that you are happy with it. Dismiss

Anti-CD152 / CTLA-4 Antibody [UC10-4F10-11]https://enquirebio.com/wp-content/uploads/2017/10/enQuire-Bio-QAB58-APC-100ug-anti-Anti-CD152-antibody-10-300x147.pnghttps://enquirebio.com/wp-content/uploads/2017/10/enQuire-Bio-QAB58-PE-100ug-anti-Anti-CD152-antibody-10-300x141.pnghttps://enquirebio.com/wp-content/uploads/2017/10/enQuire-Bio-QAB58-PE7-100ug-anti-Anti-CD152-antibody-10-300x152.pnghttps://enquirebio.com/wp-content/uploads/2017/11/enQuire-Bio-QAB58-APC-100ug-anti-Anti-CD152-antibody-9-300x147.pnghttps://enquirebio.com/wp-content/uploads/2017/11/enQuire-Bio-QAB58-PE7-100ug-anti-Anti-CD152-antibody-9-300x152.png