Formalin-fixed, paraffin-embedded human Endometrium stained with ASRGL1 Monoclonal Antibody (CRASH/1289).
Formalin-fixed, paraffin-embedded human Endometrium stained with ASRGL1 Monoclonal Antibody (CRASH/1289).Formalin-fixed, paraffin-embedded human Uterus stained with ASRGL1 Monoclonal Antibody (CRASH/1289).

Anti-ASRGL1 Antibody Clone CRASH/1289

$ 199.00$ 459.00
Please Select Product Options Below To View The Catalog Number.

SKU: 80150-MSM1
Species: Human
Tested Applications: Immunohistochemistry (IHC)
Available Conjugates: Unconjugated
Isotype: Mouse IgG1
Mass Spec Validated?: Not MS Validated

Product NumberDescriptionPrice
80150-MSM1-P0 Size: 20 ug, Tag: Unconjugated $ 199.00
80150-MSM1-P1 Size: 100 ug, Tag: Unconjugated $ 429.00
80150-MSM1-P2 Size: 200 ug, Tag: Unconjugated $ 459.00
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In Stock.
Flat Rate Shipping Anywhere in the US: $45
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SKU: 80150-MSM1-P0
ASRGL1 General Information
Alternate Names
L-asparaginase, ASRGL1
Molecular Weight
17-25kDa
Chromosomal Location
11q12.3
Curated Database and Bioinformatic Data
Gene SymbolASRGL1
Entrez Gene ID80150
Ensemble Gene IDENSG00000162174
RefSeq Protein Accession(s)XP_011543568, NP_079356, XP_005274362, XP_016873843, XP_011543567, NP_001077395, XP_005274363
RefSeq mRNA Accession(s)XM_005274305, XM_017018354, XR_001747982, NM_025080, XM_011545265, XM_005274306, XM_011545266, NM_001083926
RefSeq Genomic Accession(s)NC_000011, NC_018922
UniProt ID(s)A0A024R573, Q7L266
UniGene ID(s)A0A024R573, Q7L266
HGNC ID(s)16448
Cosmic ID(s)ASRGL1
KEGG Gene ID(s)hsa:80150
PharmGKB ID(s)PA25059
General Description of ASRGL1.
ASRGL1 (Asparaginase-like protein 1), also known as CRASH, is a 308 amino acid protein belonging to the Ntn-hydrolase family. Asparaginases utilize asparagine as a substrate to produce aspartic acid and ammonia. ASRGL1 has been identified as a autoantigenic protein that is present in the mid-piece of sperm after obstruction of the male reproductive tract. ASRGL1 is expressed highly in testis, but is also expressed in brain, kidney and gastrointestinal tissues. High levels of ASRGL1 have also been identified in ovarian, uterine and mammary tumors in comparison with normal tissues of the same origin.

Human Anti-ASRGL1 Antibody Product Attributes

Species: Human
Tested Applications: Immunohistochemistry (IHC).
Clonality: Monoclonal
Anti-ASRGL1 Antibody Clone: CRASH/1289
Clone CRASH/1289 Host and Isotype: Mouse IgG1
Anti-Human ASRGL1 Positive Control Sample: HeLa cells. Fallopian Tube, Endometrium, Uterus or Cervix.
Cellular Localization of Antibody Cytoplasmic and Nuclear
Buffer and Stabilizer: 10mM PBS with 0.05% BSA and 0.05% Azide
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Recombinant human full-length ASRGL1
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.

ASRGL1 Previously Observed Antibody Staining Patterns

Observed Subcellular, Organelle Specific Staining Data:

Anti-ASRGL1 antibody staining is expected to be primarily localized to the microtubules and nucleoplasm.

Observed Antibody Staining Data By Tissue Type:

Variations in ASRGL1 antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in cells in the seminiferous ducts in testis, glandular cells in the cervix and uterine, endometrium, epididymis and fallopian tube. More moderate antibody staining intensity was present in cells in the seminiferous ducts in testis, glandular cells in the cervix and uterine, endometrium, epididymis and fallopian tube. Low, but measureable presence of ASRGL1 could be seen in cells in the granular layer in cerebellum, cells in the tubules in kidney, glandular cells in the appendix, colon, duodenum, gallbladder, prostate and seminal vesicle, glial cells in the cerebral cortex, Leydig cells in the testis, neuronal cells in the caudate nucleus and cerebral cortex, neuropil in cerebral cortex, respiratory epithelial cells in the bronchus and nasopharynx, smooth muscle cells in the smooth muscle and urothelial cells in the urinary bladder. We were unable to detect ASRGL1 in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.

Observed Antibody Staining Data By Tissue Disease Status:

Tissues from cancer patients, for instance, have their own distinct pattern of ASRGL1 expression as measured by anti-ASRGL1 antibody immunohistochemical staining. The average level of expression by tumor is summarized in the table below. The variability row represents patient to patient variability in IHC staining.

Sample Type breast cancer carcinoid cervical cancer colorectal cancer endometrial cancer glioma head and neck cancer liver cancer lung cancer lymphoma melanoma ovarian cancer pancreatic cancer prostate cancer renal cancer skin cancer stomach cancer testicular cancer thyroid cancer urothelial cancer
Signal Intensity + - - - +++ + - - - - - ++ - + ++ - - + - -
ASRGL1 Variability +++ ++ ++ ++ ++ ++ ++ + + + + ++ ++ ++ ++ + ++ ++ ++ +

Limitations and Warranty

enQuire Bio's ASRGL1 Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

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Anti-ASRGL1 Antibody Clone CRASH/1289

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