Formalin-fixed, paraffin-embedded human Tonsil stained with BCL1 Monoclonal Antibody (SPM52).
Formalin-fixed, paraffin-embedded human Tonsil stained with BCL1 Monoclonal Antibody (SPM52).

Anti-BCL10 Antibody Clone SPM520

$ 429.00
Please Select Product Options Below To View The Catalog Number.

SKU: 8915-MSM1X
Species: Human
Tested Applications: Flow Cytometry, Immunofluorescence, Western Blot, Immunohistochemistry (IHC)
Available Conjugates: Unconjugated
Isotype: Mouse IgG1 kappa
Mass Spec Validated?: Not MS Validated

Product NumberDescriptionPrice
8915-MSM1X-P1 Size: 100 ug, Tag: Unconjugated
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In Stock.
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SKU: 8915-MSM1X-P1
BCL10 General Information
Alternate Names
B-cell lymphoma 10, B-cell leukemia 10, BCL10, BCL-10
Molecular Weight
Chromosomal Location
Curated Database and Bioinformatic Data
Gene SymbolBCL10
Entrez Gene ID8915
Ensemble Gene IDENSG00000142867
RefSeq Protein Accession(s)XP_011540700, NP_001307644, NP_003912, XP_011540701, XP_011540699
RefSeq mRNA Accession(s)XM_011542397, XM_011542398, NM_003921, NM_001320715
RefSeq Genomic Accession(s)NG_012216, NC_000001, NC_018912
UniProt ID(s)O95999, A2TDT2
UniGene ID(s)O95999, A2TDT2
HGNC ID(s)989
Cosmic ID(s)BCL10
KEGG Gene ID(s)hsa:8915
PharmGKB ID(s)PA25299
General Description of BCL10.
BCL10, with an N-terminal caspase recruitment domain (CARD), is found in a number of apoptotic regulatory molecules. It was identified through its direct involvement in t(1;14) of mucosa-associated lymphoid tissue (MALT) lymphoma. Expression of BCL10 was shown to induce NF??B activation in a NIK-dependent pathway. This MAb labels subpopulations of normal B, T cells, is a useful tool for the sub-classification of lymphomas. In MALT lymphomas with the t(1;14) translocation, while 55% of MALT lymphomas lacking this translocation exhibited the same labeling pattern, although at a much lower level.

Human Anti-BCL10 Antibody Product Attributes

Species: Human
Tested Applications: Flow Cytometry, Immunofluorescence, Western Blot, Immunohistochemistry (IHC).
Application Notes: Flow Cytometry (0.5-1ug of antibody/million cells in 0.1ml), Immunofluorescence (1-2ug of antibody/ml), Western Blot (0.5-1ug of antibody/ml), Immunohistochemistry (IHC) (Formalin-fixed) (0.5-1ug of antibody/ml for 30 minutes at RT)
Clonality: Monoclonal
Anti-BCL10 Antibody Clone: SPM520
Clone SPM520 Host and Isotype: Mouse IgG1 kappa
Anti-Human BCL10 Positive Control Sample: WEHI-231 or Ramos cells or lymphoma.
Cellular Localization of Antibody Nuclear, cytoplasmic
Buffer and Stabilizer: 10mM PBS with 0.05% BSA & 0.05% azide.
Antibody Concentration: 200ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Human BCL10 recombinant protein (epitope aa122-168)
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.

BCL10 Previously Observed Antibody Staining Patterns

Observed Subcellular, Organelle Specific Staining Data:

Anti-BCL10 antibody staining is expected to be primarily localized to the nucleoplasm.

Observed Antibody Staining Data By Tissue Type:

Variations in BCL10 antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. Low, but measureable presence of BCL10 could be seen in cells in the seminiferous ducts in testis, exocrine glandular cells in the pancreas, follicle cells in the ovary, glandular cells in the epididymis, prostate, salivary gland, stomach and thyroid gland, melanocytes in skin, neuronal cells in the cerebral cortex, squamous epithelial cells in the cervix and uterine, esophagus, oral mucosa, tonsil and vagina. We were unable to detect BCL10 in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.

Observed Antibody Staining Data By Tissue Disease Status:

Tissues from cancer patients, for instance, have their own distinct pattern of BCL10 expression as measured by anti-BCL10 antibody immunohistochemical staining. The average level of expression by tumor is summarized in the table below. The variability row represents patient to patient variability in IHC staining.

Sample Type breast cancer carcinoid cervical cancer colorectal cancer endometrial cancer glioma head and neck cancer liver cancer lung cancer lymphoma melanoma ovarian cancer pancreatic cancer prostate cancer renal cancer skin cancer stomach cancer testicular cancer thyroid cancer urothelial cancer
Signal Intensity + - + ++ + - + - + +++ + + + + - ++ ++ - + +
BCL10 Variability ++ ++ ++ ++ ++ + + ++ +++ ++ ++ ++ ++ ++ ++ ++ ++ ++ ++ ++

Limitations and Warranty

enQuire Bio's BCL10 Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

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Anti-BCL10 Antibody Clone SPM520