Formalin-fixed, paraffin-embedded human Tonsil stained with Beta-Catenin (p12) Monoclonal Antibody (CTNNB1/159).
Formalin-fixed, paraffin-embedded Mouse Colon stained with Beta-Catenin (p12) Monoclonal Antibody (CTNNB1/159).Formalin-fixed, paraffin-embedded Rat Colon stained with Beta-Catenin (p12) Monoclonal Antibody (CTNNB1/159).

Anti-Beta Catenin Antibody Clone CTNNB1/1509

$ 118.00$ 418.00
Please Select Product Options Below To View The Catalog Number.

SKU: 1499-MSM9
Species: Human, Mouse, and Rat
Tested Applications: Immunohistochemistry (IHC)
Available Conjugates: Unconjugated
Isotype: Mouse IgG1 kappa
Mass Spec Validated?: Not MS Validated

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Datasheets and Documentation
Product Datasheet
SKU: 1499-MSM9-P0
Beta Catenin General Information
Alternate Names
FCERI, FCER1A
Molecular Weight
92kDa
Chromosomal Location
3p22.1
Curated Database and Bioinformatic Data
Gene SymbolCTNNB1
Entrez Gene ID1499
Ensemble Gene IDENSG00000168036
RefSeq Protein Accession(s)XP_016861227, NP_001091679, XP_005264943, NP_001091680, XP_006713046, XP_006713047, NP_001317658, XP_006713048, NP_001895
RefSeq mRNA Accession(s)XM_006712984, XM_006712983, NM_001904, XM_017005738, NM_001098209, NM_001330729, NM_001098210, XM_006712985
RefSeq Genomic Accession(s)NC_018914, NG_013302, NC_000003
UniProt ID(s)A0A024R2Q3, P35222, B4DGU4
UniGene ID(s)A0A024R2Q3, P35222, B4DGU4
HGNC ID(s)2514
Cosmic ID(s)CTNNB1
KEGG Gene ID(s)hsa:1499
PharmGKB ID(s)PA27013
General Description of Beta Catenin.
Beta-catenin associates with the cytoplasmic portion of E-cadherin, which is necessary for the function of E-cadherin as an adhesion molecule. In normal tissues, beta-catenin is localized to the membrane of epithelial cells, consistent with its role in the cell adhesion complex. In breast ductal neoplasia, beta-catenin is usually localized in cellular membranes. However, in lobular neoplasia, a marked redistribution of beta-catenin throughout the cytoplasm results in a diffuse cytoplasmic pattern. Immuno-staining of beta-catenin and E-cadherin is helps in the accurate identification of ductal and lobular neoplasms, including a distinction between low-grade ductal carcinoma in situ (DCIS) and lobular carcinoma. Additionally, some rectal and gastric adenocarcinomas demonstrate diffuse cytoplasmic beta-catenin staining and a lack of membranous staining, mimicking the staining pattern observed with lobular breast carcinomas.

Human, Mouse, and Rat Anti-Beta Catenin Antibody Product Attributes

Species: Human, Mouse, and Rat
Tested Applications: Immunohistochemistry (IHC).
Clonality: Monoclonal
Anti-Beta Catenin Antibody Clone: CTNNB1/1509
Clone CTNNB1/1509 Host and Isotype: Mouse IgG1 kappa
Anti-Human, Mouse, and Rat Beta Catenin Positive Control Sample: HeLa or MCF-7 cells. Breast carcinoma
Cellular Localization of Antibody Cell surface and cytoplasmic
Buffer and Stabilizer: 10mM PBS with 0.05% BSA and 0.05% Azide
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Recombinant human full-length beta-Catenin (p120) protein fragment
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.

Beta Catenin Previously Observed Antibody Staining Patterns

Observed Subcellular, Organelle Specific Staining Data:

Anti-CTNNB1 antibody staining is expected to be primarily localized to the plasma membrane.

Observed Antibody Staining Data By Tissue Type:

Variations in Beta Catenin antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in bile duct cells in the liver, cells in the seminiferous ducts in testis, cells in the tubules in kidney, epidermal cells in the skin, exocrine glandular cells in the pancreas, glandular cells in the adrenal gland, appendix, breast, cervix, uterine, colon, duodenum, endometrium, epididymis, fallopian tube, gallbladder, parathyroid gland, prostate, rectum, salivary gland, seminal vesicle, small intestine, stomach and thyroid gland, hepatocytes in liver, keratinocytes in skin, myocytes in heart muscle, myoepithelial cells in the breast, respiratory epithelial cells in the bronchus and nasopharynx, squamous epithelial cells in the cervix, uterine, esophagus, oral mucosa, tonsil and vagina, trophoblastic cells in the placenta and urothelial cells in the urinary bladder. More moderate antibody staining intensity was present in bile duct cells in the liver, cells in the seminiferous ducts in testis, cells in the tubules in kidney, epidermal cells in the skin, exocrine glandular cells in the pancreas, glandular cells in the adrenal gland, appendix, breast, cervix, uterine, colon, duodenum, endometrium, epididymis, fallopian tube, gallbladder, parathyroid gland, prostate, rectum, salivary gland, seminal vesicle, small intestine, stomach and thyroid gland, hepatocytes in liver, keratinocytes in skin, myocytes in heart muscle, myoepithelial cells in the breast, respiratory epithelial cells in the bronchus and nasopharynx, squamous epithelial cells in the cervix, uterine, esophagus, oral mucosa, tonsil and vagina, trophoblastic cells in the placenta and urothelial cells in the urinary bladder. Low, but measureable presence of Beta Catenin could be seen in cells in the endometrial stroma in endometrium, cells in the glomeruli in kidney, cells in the molecular layer in cerebellum, endothelial cells in the cerebral cortex, fibroblasts in skin, glial cells in the caudate nucleus, cerebral cortex and hippocampus, hematopoietic cells in the bone marrow, Leydig cells in the testis, neuronal cells in the caudate nucleus, cerebral cortex and hippocampus, ovarian stroma cells in the ovary and Purkinje cells in the cerebellum. We were unable to detect Beta Catenin in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.

Observed Antibody Staining Data By Tissue Disease Status:

Tissues from cancer patients, for instance, have their own distinct pattern of Beta Catenin expression as measured by anti-Beta Catenin antibody immunohistochemical staining. The average level of expression by tumor is summarized in the table below. The variability row represents patient to patient variability in IHC staining.

Sample Type breast cancer carcinoid cervical cancer colorectal cancer endometrial cancer glioma head and neck cancer liver cancer lung cancer lymphoma melanoma ovarian cancer pancreatic cancer prostate cancer renal cancer skin cancer stomach cancer testicular cancer thyroid cancer urothelial cancer
Signal Intensity +++ ++ +++ +++ +++ + +++ +++ +++ - +++ +++ +++ +++ ++ +++ ++ + +++ +++
CTNNB1 Variability ++ ++ ++ + + +++ ++ ++ ++ + + ++ + + ++ + ++ ++ + ++

Limitations and Warranty

enQuire Bio's Beta Catenin Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

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