Formalin-fixed, paraffin-embedded human Colon Carcinoma stained with Blood Group Antigen A Monoclonal Antibody (3-3A)
Formalin-fixed, paraffin-embedded human Colon Carcinoma stained with Blood Group Antigen A Monoclonal Antibody (3-3A)

Anti-Blood Group Antigen A Antibody Clone 3-3A

$ 298.00
Please Select Product Options Below To View The Catalog Number.

SKU: 28-MSM9
Species: Human
Tested Applications: Immunofluorescence, Immunohistochemistry (IHC)
Available Conjugates: Unconjugated
Isotype: Mouse IgG1 kappa
Mass Spec Validated?: Not MS Validated

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Datasheets and Documentation
Product Datasheet
SKU: 28-MSM9-P1
Blood Group Antigen A General Information
Alternate Names
Histo-blood group ABO system transferase, ABO
Molecular Weight
Multiple
Chromosomal Location
9q34.2
Curated Database and Bioinformatic Data
Gene SymbolABO
Entrez Gene ID28
Ensemble Gene IDENSG00000281879, ENSG00000175164
RefSeq Protein Accession(s)NP_065202
RefSeq mRNA Accession(s)NM_020469
RefSeq Genomic Accession(s)NW_009646201, NG_006669, NC_018920, NC_000009
UniProt ID(s)A0A089QDC1, P16442
UniGene ID(s)A0A089QDC1, P16442
HGNC ID(s)79
Cosmic ID(s)ABO
KEGG Gene ID(s)hsa:28
PharmGKB ID(s)PA24415
General Description of Blood Group Antigen A.
This MAb preferably reacts with determinants of chain A, H type 3(Gal1-3GalNAc-R), 4 (Gal1-3GalNAc-R), but not with type 1, 2 chain structures. It is not reactive with immuno-dominant A trisaccharide. This MAb is applicable for tissue staining in tumor patients with blood groups A, AB. It shows a highly heterogeneous reactivity in human colon tumor tissue, adjacent mucosa. Blood-group antigens are generally defined as molecules formed by sequential addition of saccharides to the carbohydrate side chains of lipids, proteins detected on erythrocytes, certain epithelial cells. The A, B, H antigens are reported to undergo modulation during malignant cellular transformation. Blood group related antigens represent a group of carbohydrate determinants carried on both glycolipids, glycoproteins. They are usually mucin-type,, are detected on erythrocytes, certain epithelial cells,, in secretions of certain individuals. Sixteen genetically, biosynthetically distinct but inter-related specificities belong to this group of antigens, including A, B, H, Lewis A, Lewis B, Lewis X, Lewis Y,, precursor type 1 chain antigens.

Human Anti-Blood Group Antigen A Antibody Product Attributes

Species: Human
Tested Applications: Immunofluorescence, Immunohistochemistry (IHC).
Application Notes: Immunofluorescence (0.5-1ug of antibody/ml), Immunohistochemistry (IHC) (Formalin-fixed) (0.5-1.0ug of antibody/ml for 30 minutes at RT)
Clonality: Monoclonal
Anti-Blood Group Antigen A Antibody Clone: 3-3A
Clone 3-3A Host and Isotype: Mouse IgG1 kappa
Anti-Human Blood Group Antigen A Positive Control Sample: KG1 cells or human colorectal carcinoma tissues.
Cellular Localization of Antibody Cell Surface
Buffer and Stabilizer: 10mM PBS with 0.05% BSA & 0.05% azide.
Antibody Concentration: 200ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Mucin isolated from an ovarian cyst fluid
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.

Blood Group Antigen A Previously Observed Antibody Staining Patterns

Limitations and Warranty

enQuire Bio's Blood Group Antigen A Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

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