Immunohistochemical staining of c-myc  of human FFPE tissue followed by incubation with HRP labeled secondary and development with DAB substrate.

c-myc [90000000000] Antibody (cGMP).

$ 128.00$ 458.00
Please Select Product Options Below To View The Catalog Number.

SKU: QIVD75
Species: Human
Tested Applications: IHC [IVD]
Available Conjugates:
Isotype: Mouse IgG1

Product NumberDescriptionPrice
QIVD75-0.1ml Size: 0.1 ml, Format: Concentrate $ 128.00
QIVD75-0.5ml Size: 0.5 ml, Format: Concentrate $ 278.00
QIVD75-1ml Size: 1 ml, Format: Concentrate $ 458.00
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In Stock
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Datasheets and Documentation
Product Datasheet
Certificate of Analysis and Tags (Coming Soon)
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SKU: QIVD75-0.1ml
c-myc General Information
Alternate Names
Molecular Weight
48.8 kDa
Chromosomal Location
q24.21 [chr: 8] [chr_start: 127735434] [chr_end: 127742950] [strand: 1]
Curated Database and Bioinformatic Data
Gene SymbolMYC
Entrez Gene ID4609
RefSeq Protein Accession(s)NP_002458
RefSeq mRNA Accession(s); NM_001354870; NM_002467
RefSeq Genomic Accession(s)NC_000008; NG_007161
UniProt ID(s)P01106
PharmGKB ID(s)PA31353
KEGG Gene ID(s)hsa:4609
Associated Diseases (KEGG IDs)A chromosomal aberration involving MYC may be a cause of a form of B-cell chronic lymphocytic leukemia. Translocation t(8;12)(q24;q22) with BTG1. {ECO:0000269|PubMed:2069907}.; Burkitt lymphoma (BL) [MIM:113970]: A form of undifferentiated malignant lymphoma commonly manifested as a large osteolytic lesion in the jaw or as an abdominal mass. {ECO:0000269|PubMed:2166998, ECO:0000269|PubMed:8220424}. The gene represented in this entry is involved in disease pathogenesis. Chromosomal aberrations involving MYC are usually found in Burkitt lymphoma. Translocations t(8;14), t(8;22) or t(2;8) which juxtapose MYC to one of the heavy or light chain immunoglobulin gene loci.
General Description of c-myc .
This antibody recognizes an epitope located in the amino acid residue 410-419 of human oncogene product c-myc. This antibody reacts with both components of the p62 and p64 c-myc.

Antibody (Suitable for clinical applications)

Sample Type: FFPE Patient Samples.
Tested Applications: IHC. Approved for In Vitro Diagnostic Procedures on FFPE tissues. For tissue collection recommendations, please see datasheet sent with product.
Application Notes
Specification Recommendation
Recommended Dilution (Conc) 1:25-1:50
Pretreatment EDTA Buffer pH 8.0
Incubation Parameters 30 min at Room Temperature

Prior to use, inspect vial for the presence of any precipitate or other unusual physical properties. These can indicate that the antibody has degraded and is no longer suitable for patient samples. Please run positive and negative controls simultaneously with all patient samples to account and control for errors in laboratory procedure. Use of methods or materials not recommended by enQuire Bio including change to dilution range and detection system should be routinely validated by the user.

Clonality: Monoclonal
Anti-c-myc Antibody Clone: 90000000000
Host and Isotype: Mouse IgG1
Recommended Positive Control Sample: Breast carcinoma
Cellular Localization of Antibody 90000000000 Staining: Nuclear
Buffer and Stabilizer: PBS with 1% BSA and 0.05% NaN3
Antibody Concentration: Lot specific. Plese contact tech support for data.
Immunogen: Synthetic peptide corresponding to residues 408-439 of the human p62c-myc protein.
Storage Conditions: This antibody should be stored refrigerated (2-8°C). This product should not be used past the expiration date printed on the vial.

c-myc Information for Pathologists

Summary:

Proto-oncogene at 8q24.1 produces short lived nuclear phosphoprotein. Overexpressed by t(8;14)(q24;q32.3), t(8;22);(q24;11) and t(2;8);(p11-12;q24), which translocate c-myc gene next to immunoglobulin genes in Burkitt’s lymphoma. Gene expressed in virtually all eukaryotic cells; expression usually tightly controlled. Immediate early growth response gene; rapidly induced when quiescent cells receive a signal to divide; required for cells to enter S phase.

Limitations and Warranty

This antibody is manufactured in accordance with clinical good manufacturing practices in an ISO13485:2016 certified production facility. It is intended for multiple uses including in vitro diagnostic use and research use only applications. Please see vial label for expiration date. We strive to always deliver antibodies with a shelf life of at least two years.

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c-myc [90000000000] Antibody (cGMP).