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Anti-C-Reactive Protein / CRP Antibody Clone CRP-Q10

$ 199.00
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SKU: QDX42
Species: Human
Tested Applications: ELISA, LEITA, LFIA (Lateral Flow Immunoassay)
Available Conjugates: Unconjugated
Isotype: Mouse IgG
Mass Spec Validated?: Not MS Validated

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Datasheets and Documentation
Product Datasheet
SKU: QDX42-100ug
C-Reactive Protein / CRP General Information
Alternate Names
C-Reactive Protein, CRP
Curated Database and Bioinformatic Data
Gene SymbolCRP
Entrez Gene ID1401
Ensemble Gene IDENSG00000132693
RefSeq Protein Accession(s)NP_001315987, NP_001315986, XP_011507509, NP_000558
RefSeq mRNA Accession(s)NM_001329058 NM_001329057, NM_000567, XM_011509207
RefSeq Genomic Accession(s)NC_018912, NG_013007, NC_000001
UniProt ID(s)P02741
UniGene ID(s)P02741
HGNC ID(s)2367
Cosmic ID(s)CRP
KEGG Gene ID(s)hsa:1401
PharmGKB ID(s)PA120
General Description of C-Reactive Protein / CRP.
C-reactive protein (CRP) is a protein found in the blood which is measured in the plasma. Its levels rise in response to inflammation. It is an acute-phase protein of hepatic origin that increases following interleukin-6 secretion by macrophages and T cells.

CRP is used mainly as a marker of inflammation. The level of C-reactive protein (CRP) which can be measured in human blood increases in the presence of inflammation. Because CRP does not remain in the area of inflammation, a CRP test can only reveal inflammation but is not location specific. It is often measured to indicate the presence of particular disease or the effectiveness of treatments. A high-sensitivity C-reactive protein test (hs-CRP), also can be used to identify coronary artery disease.

However, a low CRP level does not always indicate the absence of inflammation. Levels of CRP may not be increased in people with autimmune diseases like rheumatoid arthritis and lupus.

Human Anti-C-Reactive Protein / CRP Antibody Product Attributes

Species: Human
Tested Applications: ELISA, LEITA, LFIA (Lateral Flow Immunoassay).
Clonality: Monoclonal
Anti-C-Reactive Protein / CRP Antibody Clone: CRP-Q10
Clone CRP-Q10 Host and Isotype: Mouse IgG
Buffer and Stabilizer: PBS (pH 7.4)
Antibody Purification Method:Protein G
Storage Conditions: Upon receipt aliquot and store at -20C or -80C. Avoid repeated freeze.

C-Reactive Protein / CRP Previously Observed Antibody Staining Patterns

Observed Antibody Staining Data By Tissue Type:

Variations in C-Reactive Protein / CRP antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in hepatocytes in liver. More moderate antibody staining intensity was present in hepatocytes in liver. Low, but measureable presence of C-Reactive Protein / CRP could be seen infibroblasts in mesenchymal tissue and glandular cells in the gallbladder. We were unable to detect C-Reactive Protein / CRP in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.

Observed Antibody Staining Data By Tissue Disease Status:

Tissues from cancer patients, for instance, have their own distinct pattern of C-Reactive Protein / CRP expression as measured by anti-C-Reactive Protein / CRP antibody immunohistochemical staining. The average level of expression by tumor is summarized in the table below. The variability row represents patient to patient variability in IHC staining.

Sample Type breast cancer carcinoid cervical cancer colorectal cancer endometrial cancer glioma head and neck cancer liver cancer lung cancer lymphoma melanoma ovarian cancer pancreatic cancer prostate cancer renal cancer skin cancer stomach cancer testicular cancer thyroid cancer urothelial cancer
Signal Intensity - - - - - - - ++ - - - - + - - - - - - -
CRP Variability + ++ + ++ + + ++ +++ ++ ++ + ++ ++ + ++ + + + ++ ++

Limitations and Warranty

enQuire Bio's Anti-Human C-Reactive Protein / CRP Antibody is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

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