Antibody (Suitable for clinical applications)
Sample Type: FFPE Patient Samples.
Tested Applications: IHC. Approved for In Vitro Diagnostic Procedures on FFPE tissues. For tissue collection recommendations, please see datasheet sent with product.
|Recommended Dilution (Conc)||1:25-1:50|
|Pretreatment||Citrate Buffer pH 6.0|
|Incubation Parameters||30 min at Room Temperature|
Prior to use, inspect vial for the presence of any precipitate or other unusual physical properties. These can indicate that the antibody has degraded and is no longer suitable for patient samples. Please run positive and negative controls simultaneously with all patient samples to account and control for errors in laboratory procedure. Use of methods or materials not recommended by enQuire Bio including change to dilution range and detection system should be routinely validated by the user.
Anti-CA 19-9 Antibody Clone: C241:5:1:4
Host and Isotype: Mouse IgG1
Recommended Positive Control Sample: Colon carcinoma
Cellular Localization of Antibody C241:5:1:4 Staining: Cytoplasmic
Buffer and Stabilizer: PBS with 1% BSA and 0.05% NaN3
Antibody Concentration: Lot specific. Plese contact tech support for data.
Immunogen: Human colorectal adenocarcinoma cell line COLO 205.
Storage Conditions: This antibody should be stored refrigerated (2-8°C). This product should not be used past the expiration date printed on the vial.
CA 19-9 Information for Pathologists
Summary:Modified Lewis(a) blood group antigen secreted by or expressed on the surface of cancer cells. Used primarily as a serum tumor marker to screen for pancreatic cancer and to monitor effectiveness of therapy. However, only 50 - 75% sensitive for initial screening of pancreatic cancer and relatively nonspecific. Terminology Carbohydrate Antigen 19-9.
Notable Clinical Features:Used primarily as a serum biomarker. As a serum screening test for pancreatic cancer, is more sensitive than CEA but less sensitive than CXCL8 (Pol Arch Intern Med 2018 Jul 27 [Epub ahead of print]). Used to screen for pancreatic cancer but has limited sensitivity and specificity. May also be elevated in patients with cholangiocarcinoma or colon cancer. Serum levels also elevated in cirrhosis, cholestasis and pancreatitis but values are usually below 1,000 U/mL.
Limitations and Warranty
This antibody is manufactured in accordance with clinical good manufacturing practices in an ISO13485:2016 certified production facility. It is intended for multiple uses including in vitro diagnostic use and research use only applications. Please see vial label for expiration date. We strive to always deliver antibodies with a shelf life of at least two years.
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