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Anti-Catenin, alpha-1 Antibody Clone 1G5

$ 148.00$ 518.00
Please Select Product Options Below To View The Catalog Number.

SKU: 1495-MSM1
Species: Human
Tested Applications: Western Blot
Available Conjugates: Unconjugated
Isotype: Mouse IgG1
Mass Spec Validated?: Not MS Validated

Product NumberDescriptionPrice
1495-MSM1-P0 : 20-ug: unconjugated $ 148.00
1495-MSM1-P0-P1 : 100-ug: unconjugated $ 368.00
1495-MSM1-P0-P2 : 200-ug: unconjugated $ 518.00
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In Stock: 1-2 Day Lead Time.
Flat Rate Shipping Anywhere in the US: $45
Datasheets and Documentation
Product Datasheet
SKU: 1495-MSM1-P0
Catenin, alpha-1 General Information
Alternate Names
alphaE-catenin, Catenin alpha-1, aE-catenin, CTNNA1, ?Ecatenin
Molecular Weight
102kDa
Chromosomal Location
5q31.2
Curated Database and Bioinformatic Data
Gene SymbolCTNNA1
Entrez Gene ID1495
Ensemble Gene IDENSG00000044115
RefSeq Protein Accession(s)NP_001310915, NP_001310932, NP_001310937, NP_001310942, NP_001310914, NP_001310933, NP_001310934, NP_001310912, NP_001310917, NP_001310918, NP_001310919, NP_001310922, NP_001310931, NP_001277236, NP_001277239, NP_001310911, NP_001310926, NP_001277241, NP_001310927, NP_001310929, NP_001310939, NP_001310940, NP_001310916, NP_001310921, NP_001310923, NP_001310924, NP_001310930, NP_001310938, NP_001277238, NP_001310913, NP_001310920, NP_001310936, NP_001894, NP_001310925, NP_001310928, NP_001310935, NP_001310941
RefSeq mRNA Accession(s)NM_001903, NM_001290307, NM_001324010, NM_001290310, NM_001323991, NM_001323994, NM_001324002, NM_001324004, NM_001324013, NM_001323983, NM_001323985, NM_001323992, NM_001323993, NM_001323996, NM_001323999, NM_001324003, NM_001324005, NM_001290309, NM_001323987, NM_001323988, NM_001323997, NM_001324009, NM_001323986, NM_001323990, NM_001324006, NM_001324008, NM_001323982, NM_001323984, NM_001323989, NM_001323995, NM_001323998, NM_001324011 NM_001324000, NM_001324012, NM_001290312, NM_001324001, NM_001324007
RefSeq Genomic Accession(s)NG_047029, NC_000005, NC_018916
UniProt ID(s)B4DKT9, P35221, B4DU00, G3XAM7
UniGene ID(s)B4DKT9, P35221, B4DU00, G3XAM7
HGNC ID(s)2509
Cosmic ID(s)CTNNA1
KEGG Gene ID(s)hsa:1495
PharmGKB ID(s)PA27008
General Description of Catenin, alpha-1.
Recognizes a protein of 102kDa, identified as Catenin, alpha-1. Catenins comprise a large family of Ca2+-dependent, homotypic cell-cell adhesion molecules that play important roles in development, epithelial cell polarity and tumor progression. Alpha-catenin is a key regulator of actin dynamics in cell-cell adhesion. During cell-cell adhesion, ?-catenin forms a heterodimer with ?-catenin and links the cadherins to actin associated with the cytoskeleton. Alpha-catenin also regulates the beta-catenin signaling in various cells. It displays the tumor suppressor activity and is found to be down regulated in some forms of breast cancer.

Human Anti-Catenin, alpha-1 Antibody Product Attributes

Species: Human
Tested Applications: Western Blot.
Clonality: Monoclonal
Anti-Catenin, alpha-1 Antibody Clone: 1G5
Clone 1G5 Host and Isotype: Mouse IgG1
Anti-Human Catenin, alpha-1 Positive Control Sample: HeLa, A431 or MCF-7 Cells.
Cellular Localization of Antibody Cell Surface
Buffer and Stabilizer: 10mM PBS with 0.05% BSA and 0.05% Azide
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Human alpha catenin fusion protein
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.

Catenin, alpha-1 Previously Observed Antibody Staining Patterns

Observed Subcellular, Organelle Specific Staining Data:

Anti-CTNNA1 antibody staining is expected to be primarily localized to the cell junctions and plasma membrane.

Observed Antibody Staining Data By Tissue Type:

Variations in Catenin, alpha-1 antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in cells in the endometrial stroma in endometrium, cells in the seminiferous ducts in testis, cells in the tubules in kidney, decidual cells in the placenta, exocrine glandular cells in the pancreas, glandular cells in the appendix, colon, duodenum, endometrium, epididymis, fallopian tube, gallbladder, rectum, salivary gland, seminal vesicle, small intestine, stomach and thyroid gland, myocytes in heart muscle and skeletal muscle, respiratory epithelial cells in the bronchus and nasopharynx, squamous epithelial cells in the oral mucosa and vagina, trophoblastic cells in the placenta and urothelial cells in the urinary bladder. More moderate antibody staining intensity was present in cells in the endometrial stroma in endometrium, cells in the seminiferous ducts in testis, cells in the tubules in kidney, decidual cells in the placenta, exocrine glandular cells in the pancreas, glandular cells in the appendix, colon, duodenum, endometrium, epididymis, fallopian tube, gallbladder, rectum, salivary gland, seminal vesicle, small intestine, stomach and thyroid gland, myocytes in heart muscle and skeletal muscle, respiratory epithelial cells in the bronchus and nasopharynx, squamous epithelial cells in the oral mucosa and vagina, trophoblastic cells in the placenta and urothelial cells in the urinary bladder. Low, but measureable presence of Catenin, alpha-1 could be seen inadipocytes in breast and mesenchymal tissue, bile duct cells in the liver, cells in the glomeruli in kidney, cells in the granular layer in cerebellum, cells in the red pulp in spleen, chondrocytes in mesenchymal tissue, fibroblasts in skin and mesenchymal tissue, germinal center cells in the tonsil, melanocytes in skin, myoepithelial cells in the breast, neuronal cells in the caudate nucleus, cerebral cortex and hippocampus, ovarian stroma cells in the ovary, pneumocytes in lung and smooth muscle cells in the smooth muscle. We were unable to detect Catenin, alpha-1 in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.

Observed Antibody Staining Data By Tissue Disease Status:

Tissues from cancer patients, for instance, have their own distinct pattern of Catenin, alpha-1 expression as measured by anti-Catenin, alpha-1 antibody immunohistochemical staining. The average level of expression by tumor is summarized in the table below. The variability row represents patient to patient variability in IHC staining.

Sample Type breast cancer carcinoid cervical cancer colorectal cancer endometrial cancer glioma head and neck cancer liver cancer lung cancer lymphoma melanoma ovarian cancer pancreatic cancer prostate cancer renal cancer skin cancer stomach cancer testicular cancer thyroid cancer urothelial cancer
Signal Intensity +++ ++ ++ ++ ++ + +++ ++ ++ + ++ ++ +++ ++ ++ ++ ++ ++ ++ ++
CTNNA1 Variability ++ ++ ++ ++ ++ ++ ++ ++ ++ ++ ++ + ++ + ++ ++ ++ +++ ++ ++

Limitations and Warranty

enQuire Bio's Catenin, alpha-1 Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

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Anti-Catenin, alpha-1 Antibody Clone 1G5