Formalin-fixed, paraffin-embedded human Lung Carcinoma stained with CD11c Monoclonal Antibody (ITGAX/1243) at 1ug/ml. Antigen retrieval in 1mM Tris with 1mM EDTA, pH 9.; ABC detection system with DAB Chromogen. Note staining of Lung cancer cells.
Formalin-fixed, paraffin-embedded human Lung Carcinoma stained with CD11c Monoclonal Antibody (ITGAX/1243) at 1ug/ml. Antigen retrieval in 1mM Tris with 1mM EDTA, pH 9.; ABC detection system with DAB Chromogen. Note staining of Lung cancer cells.Formalin-fixed, paraffin-embedded human Follicular Lymphoma stained with CD11c Monoclonal Antibody (ITGAX/1243) at 1ug/ml. Antigen retrieval in 1mM Tris with 1mM EDTA, pH 9.; ABC detection system with DAB Chromogen. Note staining of cancer cells.

Anti-CD11c Antibody Clone ITGAX/1243

$ 148.00$ 518.00
Please Select Product Options Below To View The Catalog Number.

SKU: 3687-MSM3
Species: Human
Tested Applications: Immunohistochemistry (IHC)
Available Conjugates: Unconjugated
Isotype: Mouse IgG2b kappa
Mass Spec Validated?: Not MS Validated

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Datasheets and Documentation
Product Datasheet
SKU: 3687-MSM3-P0
CD11c General Information
Alternate Names
CD11 antigen-like family member C, Complement component 3 receptor 4 subunit, Integrin alpha-X, integrin, alpha X (antigen CD11C (p150), alpha polypeptide), Leu M5 alpha subunit, Leukocyte adhesion glycoprotein p150 95 alpha chain, Myeloid membrane antigen alpha subunit, p150/95, anti-CD11 antigen-like family member C antibody, anti-Complement component 3 receptor 4 subunit antibody, anti-Integrin alpha-X antibody, anti-integrin, alpha X (antigen CD11C (p150), alpha polypeptide) antibody, anti-Leu M5 alpha subunit antibody, anti-Leukocyte adhesion glycoprotein p150 95 alpha chain antibody, anti-Myeloid membrane antigen alpha subunit antibody, anti-p150/95 antibody
Molecular Weight
145kDa
Curated Database and Bioinformatic Data
Entrez Gene ID3687
Ensemble Gene IDENSG00000140678
RefSeq Protein Accession(s)XP_011544156, NP_000878, NP_001273304, XP_011544154
RefSeq mRNA Accession(s)NM_001286375, NM_000887 XR_950797, XM_011545852, XM_011545854
RefSeq Genomic Accession(s)NG_011451, NC_000016, NC_018927
UniProt ID(s)H3BN02, P20702
UniGene ID(s)H3BN02, P20702
HGNC ID(s)6152
Cosmic ID(s)ITGAX
KEGG Gene ID(s)hsa:3687
PharmGKB ID(s)PA29952
General Description of CD11c.
Recognizes a protein of 145kDa, identified as CD11c. CD11c (ITGAX), a member of the leukointegrin family, shares the same beta subunit with other members of the leukocyte adhesion molecule family, which includes CD11a (LFA-1), CD11b (MAC-1) and CD11d (ITGAD), but has a unique alpha chain. CD11c has been shown to play a role in phagocytosis, cell migration, and cytokine production by monocytes/macrophages as well as induction of T-cell proliferation by Langerhans cells. CD11c is expressed prominently on the plasma membranes of monocytes, tissue macrophages, NK cells, and most dendritic cells (DCs). A lower level of expression is also observed on neutrophils as a result of its high level of expression on most DCs. An antibody to CD11c may aid in identification of lesions with histiocytic origin. It may also been used as a marker for hairy cell leukemia in paraffin-embedded tissues.

Human Anti-CD11c Antibody Product Attributes

Species: Human
Tested Applications: Immunohistochemistry (IHC).
Clonality: Monoclonal
Anti-CD11c Antibody Clone: ITGAX/1243
Clone ITGAX/1243 Host and Isotype: Mouse IgG2b kappa
Anti-Human CD11c Positive Control Sample: Human dendritic cells. Human lymph nodes and tonsils.
Cellular Localization of Antibody Cell surface
Buffer and Stabilizer: 10mM PBS with 0.05% BSA and 0.05% Azide
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Recombinant human ITGAX protein fragment (aa 637-827)
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.

CD11c Previously Observed Antibody Staining Patterns

Limitations and Warranty

enQuire Bio's CD11c Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

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Anti-CD11c Antibody Clone ITGAX/1243

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