Formalin-fixed, paraffin-embedded human Tonsil stained with CD11c Monoclonal Antibody (ITGAX/1284).
Formalin-fixed, paraffin-embedded human Tonsil stained with CD11c Monoclonal Antibody (ITGAX/1284).

Anti-CD11c Antibody Clone ITGAX/1284

$ 118.00$ 418.00
Please Select Product Options Below To View The Catalog Number.

SKU: 3687-MSM4
Species: Human
Tested Applications: Immunohistochemistry (IHC)
Available Conjugates: Unconjugated
Isotype: Mouse IgG2b
Mass Spec Validated?: Not MS Validated

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Datasheets and Documentation
Product Datasheet
SKU: 3687-MSM4-P0
CD11c General Information
Alternate Names
CD11c, Integrin, alpha X, complement component 3 receptor 4 subunit), ITGAX)
Molecular Weight
145kDa
Chromosomal Location
16p11.2
Curated Database and Bioinformatic Data
Gene SymbolITGAX
Entrez Gene ID3687
Ensemble Gene IDENSG00000140678
RefSeq Protein Accession(s)XP_011544156, NP_000878, NP_001273304, XP_011544154
RefSeq mRNA Accession(s)NM_001286375, NM_000887 XR_950797, XM_011545852, XM_011545854
RefSeq Genomic Accession(s)NG_011451, NC_000016, NC_018927
UniProt ID(s)H3BN02, P20702
UniGene ID(s)H3BN02, P20702
HGNC ID(s)6152
Cosmic ID(s)ITGAX
KEGG Gene ID(s)hsa:3687
PharmGKB ID(s)PA29952
General Description of CD11c.
Recognizes a protein of 145kDa, identified as CD11c. CD11c (ITGAX), a member of the leukointegrin family, shares the same beta subunit with other members of the leukocyte adhesion molecule family, which includes CD11a (LFA-1), CD11b (MAC-1) and CD11d (ITGAD), but has a unique alpha chain. CD11c has been shown to play a role in phagocytosis, cell migration, and cytokine production by monocytes/macrophages as well as induction of T-cell proliferation by Langerhans cells. CD11c is expressed prominently on the plasma membranes of monocytes, tissue macrophages, NK cells, and most dendritic cells (DCs). A lower level of expression is also observed on neutrophils as a result of its high level of expression on most DCs. An antibody to CD11c may aid in identification of lesions with histiocytic origin. It may also been used as a marker for hairy cell leukemia in paraffin-embedded tissues.

Human Anti-CD11c Antibody Product Attributes

Species: Human
Tested Applications: Immunohistochemistry (IHC).
Clonality: Monoclonal
Anti-CD11c Antibody Clone: ITGAX/1284
Clone ITGAX/1284 Host and Isotype: Mouse IgG2b
Anti-Human CD11c Positive Control Sample: Human dendritic cells. Human lymph nodes and tonsils.
Cellular Localization of Antibody Cell surface
Buffer and Stabilizer: 10mM PBS with 0.05% BSA and 0.05% Azide
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Recombinant human ITGAX protein fragment (aa 637-827)
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.

CD11c Previously Observed Antibody Staining Patterns

Observed Antibody Staining Data By Tissue Type:

Variations in CD11c antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. Low, but measureable presence of CD11c could be seen inhematopoietic cells in the bone marrow, lymphoid tissue in appendix, macrophages in lung and squamous epithelial cells in the tonsil. We were unable to detect CD11c in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.

Limitations and Warranty

enQuire Bio's CD11c Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

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