Formalin-fixed, paraffin-embedded human Skin stained with CD1a Monoclonal Antibody (O1).
Formalin-fixed, paraffin-embedded human Skin stained with CD1a Monoclonal Antibody (O1).

Anti-CD1a / HTA1 Antibody Clone O10

$ 429.00
Please Select Product Options Below To View The Catalog Number.

SKU: 909-MSM1
Species: Human
Tested Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry (IHC)
Available Conjugates: Unconjugated
Isotype: Mouse IgG1 kappa
Mass Spec Validated?: Not MS Validated

Product NumberDescriptionPrice
909-MSM1-P1 Size: 100 ug, Tag: Unconjugated
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SKU: 909-MSM1-P1
CD1a / HTA1 General Information
Alternate Names
CD1a, Cluster of Differentiation 1a,
Molecular Weight
Chromosomal Location
Curated Database and Bioinformatic Data
Gene SymbolCD1A
Entrez Gene ID909
Ensemble Gene IDENSG00000158477
RefSeq Protein Accession(s)NP_001307581, NP_001754
RefSeq mRNA Accession(s)NM_001320652, NM_001763
RefSeq Genomic Accession(s)NC_018912, NC_000001
UniProt ID(s)P06126
UniGene ID(s)P06126
HGNC ID(s)1634
Cosmic ID(s)CD1A
KEGG Gene ID(s)hsa:909
PharmGKB ID(s)PA26193
General Description of CD1a / HTA1.
At least five CD1 genes (CD1a, b, c, d,, e) are identified. CD1 proteins have been demonstrated to restrict T cell response to non-peptide lipid, glycolipid antigens, play a role in non-classical antigen presentation. CD1a is a non-polymorphic MHC Class 1 related cell surface glycoprotein, expressed in association with Beta-2 microglobulin. Anti-CD1a labels Langerhans cell histiocytosis (Histiocytosis X), extranodal histiocytic sarcoma, a subset of T-lymphoblastic lymphoma/leukemia,, interdigitating dendritic cell sarcoma of the lymph node. When combined with antibodies against TTF-1, CD5, anti-CD1a is useful in distinguishing between pulmonary, thymic neoplasms since CD1a is consistently expressed in thymic lymphocytes in both typical, atypical thymomas, but only focally in 1/6 of thymic carcinomas, not in lymphocytes in pulmonary neoplasms. Anti-CD1a is reported to be a new marker for perivascular epithelial cell tumor (PEComa).

Human Anti-CD1a / HTA1 Antibody Product Attributes

Species: Human
Tested Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry (IHC).
Application Notes: Flow Cytometry (0.5-1ug of antibody/million cells in 0.1ml), Immunofluorescence (1-2ug of antibody/ml), Immunohistochemistry (IHC) (Formalin-fixed) (0.5-1ug of antibody/ml for 30 min at RT)
Clonality: Monoclonal
Anti-CD1a / HTA1 Antibody Clone: O10
Clone O10 Host and Isotype: Mouse IgG1 kappa
Anti-Human CD1a / HTA1 Positive Control Sample: MOLT-4 cells. Paracortex in a tonsil or a reactive lymph node.
Cellular Localization of Antibody Cell surface
Buffer and Stabilizer: 10mM PBS with 0.05% BSA & 0.05% azide.
Antibody Concentration: 200ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Human thymus cells
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.

CD1a / HTA1 Previously Observed Antibody Staining Patterns

Observed Antibody Staining Data By Tissue Type:

Variations in CD1a / HTA1 antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in Langerhans in skin. More moderate antibody staining intensity was present in Langerhans in skin. Low, but measureable presence of CD1a / HTA1 could be seen infibroblasts in skin. We were unable to detect CD1a / HTA1 in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.

Observed Antibody Staining Data By Tissue Disease Status:

Tissues from cancer patients, for instance, have their own distinct pattern of CD1a / HTA1 expression as measured by anti-CD1a / HTA1 antibody immunohistochemical staining. The average level of expression by tumor is summarized in the table below. The variability row represents patient to patient variability in IHC staining.

Sample Type breast cancer carcinoid cervical cancer colorectal cancer endometrial cancer glioma head and neck cancer liver cancer lung cancer lymphoma melanoma ovarian cancer pancreatic cancer prostate cancer renal cancer skin cancer stomach cancer testicular cancer thyroid cancer urothelial cancer
Signal Intensity - - - - - - - - - - - - + - - - + + - +
CD1A Variability + + + + + + + + + + + + + + ++ + ++ + + ++

Limitations and Warranty

enQuire Bio's CD1a / HTA1 Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

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Anti-CD1a / HTA1 Antibody Clone O10