enQuire-Bio-QAB89-F-100ug-anti-CD2-LY37-antibody-10
C57Bl/6 splenocytes were stained with 0.25 ug PE Mouse Anti-CD2 (QAB89) (solid line) or 0.25 ug PE Rat IgG2b (dashed line). Flow Cytometry Data from 10,000 events.

Anti-CD2 Antibody [RM2-5]

$ 48.00$ 228.00
Please Select Product Options Below To View The Catalog Number.

SKU: QAB89
Species: Mouse
Tested Applications: Flow Cytometry
Available Conjugates: FITC ;PE
Isotype: Rat IgG2b lambda
Mass Spec Validated?: Not MS Validated

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Datasheets and Documentation
Product Datasheet
SKU: QAB89-F-25ug
CD2 / LY37 General Information
Alternate Names
CD2, LY37, OX-34, CD2R, LFA-2, LFA2, OX34
Curated Database and Bioinformatic Data
Gene SymbolCd2
Entrez Gene ID12481
Ensemble Gene IDENSMUSG00000027863
RefSeq Protein Accession(s)NP_038514
RefSeq mRNA Accession(s)NM_013486
RefSeq Genomic Accession(s)NC_000069, NG_187022
UniProt ID(s)Q549Q4P08920
UniGene ID(s)Q549Q4P08920
Cosmic ID(s)Cd2
KEGG Gene ID(s)mmu:12481
General Description of CD2 / LY37.
The RM2-5 antibody reacts with mouse CD2, an approximately 50 kDa glycoprotein, and a member of the Ig superfamily. CD2, also known as LFA-2, is a receptor for CD48 in the mouse and is expressed on the cell surface of all lymphocytes. CD2 mediates cell to cell adhesion and is involved in T cell activation.RM2-5 is reported to block CD2-mediated cell:cell adhesion Please choose the appropriate format for each application.

Mouse Anti-CD2 / LY37 Antibody Product Attributes

Species: Mouse
Tested Applications: Flow Cytometry.
Application Notes: See Product Datasheet for Recommended Dilution Range. Requires Experimental Optimization
Clonality: Monoclonal Antibody
Anti-CD2 / LY37 Antibody Clone: RM2-5
Clone RM2-5 Host and Isotype: Rat IgG2b lambda
Buffer and Stabilizer: 10 mM NaH2PO4, 150 mM NaCl, 0.09% NaN3, 0.1% gelatin, pH7.2
Antibody Concentration: 0.5 mg/mL
Storage Conditions: 2-8C protected from light. Stable for 12 Months. Do Not Freeze.

CD2 / LY37 Previously Observed Antibody Staining Patterns

Observed Antibody Staining Data By Tissue Type:

Variations in CD2 / LY37 antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in cells in the white pulp in spleen. More moderate antibody staining intensity was present in cells in the white pulp in spleen. Low, but measureable presence of CD2 / LY37 could be seen in. We were unable to detect CD2 / LY37 in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.

Observed Antibody Staining Data By Tissue Disease Status:

Tissues from cancer patients, for instance, have their own distinct pattern of CD2 / LY37 expression as measured by anti-CD2 / LY37 antibody immunohistochemical staining. The average level of expression by tumor is summarized in the table below. The variability row represents patient to patient variability in IHC staining.

Sample Type breast cancer carcinoid cervical cancer colorectal cancer endometrial cancer glioma head and neck cancer liver cancer lung cancer lymphoma melanoma ovarian cancer pancreatic cancer prostate cancer renal cancer skin cancer stomach cancer testicular cancer thyroid cancer urothelial cancer
Signal Intensity - - - + - - - - - - - - - - - - - - - +
CD2 Variability + ++ + ++ + + ++ + ++ ++ + + + + + + + ++ ++ +++

Selected References

Yagita H, Nakamura T, Karasuyama H, Okumura K. 1989. Proc. Natl. Acad. Sci. 86(2):645-9. Nakamura T, Takahashi K, Fukazawa T, Koyanagi M, Yokoyama A, Kato H, Yagita H, Okumura K. 1990. J. Immunol. 145(11):3628-34. Criado G, Feito MJ, Rojo JM. 1996. Eur. J. Immunol. 26(6):1228-34. Cibotti R, Punt JA, Dash KS, Sharrow SO, Singer A. 1997. Immunity. 6(3):245-55.

Limitations and Warranty

enQuire Bio's Mouse Anti-CD2 Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

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