Formalin-fixed, paraffin-embedded human Tonsil stained with CD2 Recombinant Rabbit Monoclonal Antibody (IGEL/1497R)
Formalin-fixed, paraffin-embedded human Tonsil stained with CD2 Recombinant Rabbit Monoclonal Antibody (IGEL/1497R)

Anti-CD20 / MS4A1 Antibody Clone IGEL/1497R

$ 199.00$ 549.00
Please Select Product Options Below To View The Catalog Number.

SKU: 931-RBM7
Species: Human
Tested Applications: Immunohistochemistry (IHC)
Available Conjugates: Unconjugated
Isotype: Rabbit IgG kappa
Mass Spec Validated?: Not MS Validated

Product NumberDescriptionPrice
931-RBM7-P0 Size: 20 ug, Tag: Unconjugated $ 228.00
931-RBM7-P1 Size: 100 ug, Tag: Unconjugated $ 488.00
931-RBM7-P2 Size: 200 ug, Tag: Unconjugated $ 618.00
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In Stock.
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SKU: 931-RBM7-P0
CD20 / MS4A1 General Information
Alternate Names
B-lymphocyte antigen CD20, CD20, Cluster of Differentiation 20
Molecular Weight
33-37kDa
Chromosomal Location
11q12.2
Curated Database and Bioinformatic Data
Gene SymbolMS4A1
Entrez Gene ID931
Ensemble Gene IDENSG00000156738
RefSeq Protein Accession(s)NP_068769, NP_690605
RefSeq mRNA Accession(s)NM_152866, NM_021950
RefSeq Genomic Accession(s)NG_023388, NC_018922, NC_000011
UniProt ID(s)P11836, A0A024R507
UniGene ID(s)P11836, A0A024R507
HGNC ID(s)7315
Cosmic ID(s)MS4A1
KEGG Gene ID(s)hsa:931
PharmGKB ID(s)PA31111
General Description of CD20 / MS4A1.
Recognizes a protein of 30-33kDa, which is identified as CD20. It is a non-Ig differentiation antigen of B-cells and its expression is restricted to normal and neoplastic B-cells, being absent from all other leukocytes and tissues. CD20 is expressed by pre B-cells and persists during all stages of B-cell maturation but is lost upon terminal differentiation into plasma cells. This MAb can be used for immunophenotyping of leukemia and malignant cells, B lymphocyte detection in peripheral blood and B cell localization in tissues. It reacts with the majority of B-cells present in peripheral blood and lymphoid tissues and their derived lymphomas. In lymphoid tissue, germinal center blasts and B-immunoblasts are particularly reactive. It is a reliable antibody for ascribing a B-cell phenotype in known lymphoid tissues. Rarely, CD20-positive T-cell lymphomas have been reported. Reactivity has also been noted with Reed-Sternberg cells in cases of Hodgkin s disease, particularly of lymphocyte predominant type.

Human Anti-CD20 / MS4A1 Antibody Product Attributes

Species: Human
Tested Applications: Immunohistochemistry (IHC).
Clonality: Recombinant Monoclonal
Anti-CD20 / MS4A1 Antibody Clone: IGEL/1497R
Clone IGEL/1497R Host and Isotype: Rabbit IgG kappa
Anti-Human CD20 / MS4A1 Positive Control Sample: Daudi, Raji, and U266, and human lymphocytes. Lymph nodes and tonsils.
Cellular Localization of Antibody Predominantly cell surface with some cytoplasmic
Buffer and Stabilizer: 10mM PBS with or without 0.05% BSA & 0.05% azide.
Antibody Concentration: 200ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Recombinant human full-length MS4A1 protein
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.

CD20 / MS4A1 Previously Observed Antibody Staining Patterns

Observed Antibody Staining Data By Tissue Type:

Variations in CD20 / MS4A1 antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in lymphoid tissue in appendix, germinal center cells in the lymph node, cells in the white pulp in spleen, germinal center cells in the tonsil and non-germinal center cells in the tonsil. More moderate antibody staining intensity was present in lymphoid tissue in appendix, germinal center cells in the lymph node, cells in the white pulp in spleen, germinal center cells in the tonsil and non-germinal center cells in the tonsil. Low, but measureable presence of CD20 / MS4A1 could be seen infollicle cells in the ovary and keratinocytes in skin. We were unable to detect CD20 / MS4A1 in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.

Limitations and Warranty

enQuire Bio's CD20 / MS4A1 Recombinant Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

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Anti-CD20 / MS4A1 Antibody Clone IGEL/1497R

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