Immunohistochemical staining of CD21, B Cell  of human FFPE tissue followed by incubation with HRP labeled secondary and development with DAB substrate.

CD21, B Cell [1F8] Antibody (cGMP).

$ 135.00$ 415.00
Please Select Product Options Below To View The Catalog Number.

SKU: QIVD230
Species: Human
Tested Applications: IHC [IVD]
Available Conjugates:
Isotype: Mouse IgG1, kappa

Product NumberDescriptionPrice
QIVD230-0.1ml Size: 0.1 ml, Format: Concentrate $ 158.00
QIVD230-0.5ml Size: 0.5 ml, Format: Concentrate $ 288.00
QIVD230-1ml Size: 1 ml, Format: Concentrate $ 468.00
QIVD230-6ml Size: 6 ml, Format: Predilute $ 298.00
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Datasheets and Documentation
Product Datasheet
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SKU: QIVD230-0.1ml
CD21, B Cell General Information
Alternate Names
Molecular Weight
112.9 kDa
Chromosomal Location
q32.2 [chr: 1] [chr_start: 207454230] [chr_end: 207489895] [strand: 1]
Curated Database and Bioinformatic Data
Gene SymbolCR2
Entrez Gene ID1380
RefSeq Protein Accession(s)NP_001868; NP_001006659
RefSeq mRNA Accession(s); NM_001006658; XM_011509206; NM_001877
RefSeq Genomic Accession(s)NC_000001; NG_013006
UniProt ID(s)P20023
PharmGKB ID(s)PA26857
KEGG Gene ID(s)hsa:1380
Associated Diseases (KEGG IDs)Systemic lupus erythematosus 9 (SLEB9) [MIM:610927]: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. {ECO:0000269|PubMed:17360460}. Disease susceptibility is associated with variations affecting the gene represented in this entry.; Immunodeficiency, common variable, 7 (CVID7) [MIM:614699]: A primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low. {ECO:0000269|PubMed:22035880}. The disease is caused by mutations affecting the gene represented in this entry.
General Description of CD21, B Cell .
This antibody reacts with CD21 antigen of MW 145 kDa, present on the surface of mature B cells. The antigen is present at high density on follicular dendritic cells. CD21 is involved in transmitting growth-promoting signals to the interior of the B cell.

Antibody (Suitable for clinical applications)

Sample Type: FFPE Patient Samples.
Tested Applications: IHC. Approved for In Vitro Diagnostic Procedures on FFPE tissues. For tissue collection recommendations, please see datasheet sent with product.
Application Notes
Specification Recommendation
Recommended Dilution (Conc) 1:10-1:25
Pretreatment HistoZyme
Incubation Parameters 30 min at RoomTemperature

Prior to use, inspect vial for the presence of any precipitate or other unusual physical properties. These can indicate that the antibody has degraded and is no longer suitable for patient samples. Please run positive and negative controls simultaneously with all patient samples to account and control for errors in laboratory procedure. Use of methods or materials not recommended by enQuire Bio including change to dilution range and detection system should be routinely validated by the user.

Clonality: Monoclonal
Anti-CD21, B Cell Antibody Clone: 1F8
Host and Isotype: Mouse IgG1, kappa
Recommended Positive Control Sample: Tonsil
Cellular Localization of Antibody 1F8 Staining: Cell membrane
Buffer and Stabilizer: PBS with 1% BSA and 0.05% NaN3
Antibody Concentration: Lot specific. Plese contact tech support for data.
Immunogen: Purified receptor for the C3d fragment of the third complement component CR2, from human tonsil.
Storage Conditions: This antibody should be stored refrigerated (2-8°C). This product should not be used past the expiration date printed on the vial.

CD21, B Cell Information for Pathologists

Limitations and Warranty

This antibody is manufactured in accordance with clinical good manufacturing practices in an ISO13485:2016 certified production facility. It is intended for multiple uses including in vitro diagnostic use and research use only applications. Please see vial label for expiration date. We strive to always deliver antibodies with a shelf life of at least two years.

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CD21, B Cell [1F8] Antibody (cGMP).