Human PBMCs were stained with 5 uL  (solid line) or 0.125 ug APC Mouse IgG1 isotype control (dashed line). Flow Cytometry Data from 10,000 events.
Human PBMCs were stained with 5 uL  (solid line) or 0.125 ug APC Mouse IgG1 isotype control (dashed line). Flow Cytometry Data from 10,000 events.

Anti-CD23 Antibody [EBVCS-5]

$ 108.00$ 1,368.00
Please Select Product Options Below To View The Catalog Number.

SKU: QAB32
Species: Human
Tested Applications: Flow Cytometry
Available Conjugates: PE ;APC
Isotype: Mouse IgG1 kappa
Mass Spec Validated?: Not MS Validated

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Datasheets and Documentation
Product Datasheet
SKU: QAB32-PE-25Tests
CD23 / FCER2 / FCER2A General Information
Alternate Names
CD23, FCER2, FCER2A, BLAST-2, CD23, FCE2, CD23A, CLEC4J, IGEBF
Curated Database and Bioinformatic Data
Gene SymbolFCER2
Entrez Gene ID2208
Ensemble Gene IDENSG00000104921
RefSeq Protein Accession(s)XP_005272519, NP_001193948, NP_001207429, NP_001993
RefSeq mRNA Accession(s)XM_005272462, NM_001207019, NM_001220500 NM_002002
RefSeq Genomic Accession(s)NC_000019, NG_029554, NC_018930
UniProt ID(s)P06734, K3W4U1
UniGene ID(s)P06734, K3W4U1
HGNC ID(s)3612
Cosmic ID(s)FCER2
KEGG Gene ID(s)hsa:2208
PharmGKB ID(s)PA28058
General Description of CD23 / FCER2 / FCER2A.
The EBVCS-5 antibody is specific for human CD23, also known as the low affinity IgE receptor (FceRII), a 45 kDa type II transmembrane protein and member of the immunoglobulin superfamily. It is expressed on most B cells and is upregulated upon activation. It is also present on mantle zone B cells, eosinophils, monocytes and a subset of T cells and platelets. CD23 plays a role in B cell development and differentiation, and also functions to regulate IgE production. Soluble secreted forms of CD23 have been reported to bind IgE, stimulate release of pro-inflammatory cytokines from monocytes, and play a role in B cell differentiation.

Human Anti-CD23 / FCER2 / FCER2A Antibody Product Attributes

Species: Human
Tested Applications: Flow Cytometry.
Application Notes: 5 ul per test where one test represents staining of a cell sample in a final volume of approximately 100 uL. The number of cells within a sample must be experimentally determined, but ranges between 1x105 to 1x108 cells.
Clonality: Monoclonal Antibody
Anti-CD23 / FCER2 / FCER2A Antibody Clone: EBVCS-5
Clone EBVCS-5 Host and Isotype: Mouse IgG1 kappa
Buffer and Stabilizer: 10 mM NaH2PO4, 150 mM NaCl, 0.09% NaN3, 0.1% gelatin, pH7.2
Antibody Concentration: 5 uL /test
Storage Conditions: 2-8C protected from light. Stable for 12 Months. Do Not Freeze.

CD23 / FCER2 / FCER2A Previously Observed Antibody Staining Patterns

Observed Antibody Staining Data By Tissue Type:

Variations in CD23 / FCER2 / FCER2A antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in germinal center cells in the lymph node, tonsil. More moderate antibody staining intensity was present in germinal center cells in the lymph node, tonsil. Low, but measureable presence of CD23 / FCER2 / FCER2A could be seen inmelanocytes in skin. We were unable to detect CD23 / FCER2 / FCER2A in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.

Observed Antibody Staining Data By Tissue Disease Status:

Tissues from cancer patients, for instance, have their own distinct pattern of CD23 / FCER2 / FCER2A expression as measured by anti-CD23 / FCER2 / FCER2A antibody immunohistochemical staining. The average level of expression by tumor is summarized in the table below. The variability row represents patient to patient variability in IHC staining.

Sample Type breast cancer carcinoid cervical cancer colorectal cancer endometrial cancer glioma head and neck cancer liver cancer lung cancer lymphoma melanoma ovarian cancer pancreatic cancer prostate cancer renal cancer skin cancer stomach cancer testicular cancer thyroid cancer urothelial cancer
Signal Intensity - - - - - - - - - - - - - - - - - - - -
FCER2 Variability + + + + + + ++ + + ++ + + + + + + + + + +

Selected References

Knapp W, Dorken B, et al. eds. 1989. Leucocyte Typing IV: White Cell Differentiation Antigens. Oxford University Press. New York. Yukawa K, Kikutani H, Owaki H, Yamasaki K, Yokota A, Nakamura H, Barsumian EL, Hardy RR, Suemura M and Kishimoto T. 1987. J Immunol. 138(8): 2576-2580. Armant M, Ishihara H, Rubio M, Delespesse G and Sarfati M. 1994. J Exp Med. 1994. 180(3): 1005-1011. Belleau JT, Gandhi RK, McPherson HM and Lew DB. 2005. Clin Mol Allergy. 3:6. (Flow cytometry) Farren TW, Giustiniani J, Liu FT, Tsitsikas DA, Macey MG, Cavenagh JD, Oakervee HE, Taussig D, Newland AC, Calaminici M, Bensussan A, Jenner M, Gribben JB and Agrawal SG. 2011. Blood. 118(8): 2174-2183. (Flow cytometry) Cromvik J, Johnsson M, Vaht K, Johansson JE and Wenneras C. 2014. Immun Inflamm Dis. 2(2): 99-113. (Flow cytometry)

Limitations and Warranty

enQuire Bio's Human Anti-CD23 Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

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