Formalin-fixed, paraffin-embedded human Hodgkins Lymphoma stained with CD3 Recombinant Mouse Monoclonal Antibody (rKi-1/779).
Formalin-fixed, paraffin-embedded human Hodgkins Lymphoma stained with CD3 Recombinant Mouse Monoclonal Antibody (rKi-1/779).

Anti-CD30 / TNFRSF8 Antibody Clone rKi-1/779

$ 118.00$ 418.00
Please Select Product Options Below To View The Catalog Number.

SKU: 943-MSM8
Species: Human
Tested Applications: Immunohistochemistry (IHC)
Available Conjugates: Unconjugated
Isotype: Mouse IgG1 kappa
Mass Spec Validated?: Not MS Validated

Product NumberDescriptionPrice
943-MSM8-P0 Size: 20 ug, Tag: Unconjugated $ 118.00
943-MSM8-P1 Size: 100 ug, Tag: Unconjugated $ 298.00
943-MSM8-P2 Size: 200 ug, Tag: Unconjugated $ 418.00
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In Stock.
Flat Rate Shipping Anywhere in the US: $45
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SKU: 943-MSM8-P0
CD30 / TNFRSF8 General Information
Alternate Names
CD30, TNFRSF8
Molecular Weight
105-120kDa
Chromosomal Location
1p36.22
Curated Database and Bioinformatic Data
Gene SymbolTNFRSF8
Entrez Gene ID943
Ensemble Gene IDENSG00000120949
RefSeq Protein Accession(s)NP_001268359, NP_001234, XP_011540743, XP_011540745
RefSeq mRNA Accession(s)NM_152942, XM_011542443, NM_001281430, XM_011542441 NM_001243
RefSeq Genomic Accession(s)NC_000001, NG_029573, NC_018912,
UniProt ID(s)A5D8T4, P28908
UniGene ID(s)A5D8T4, P28908
HGNC ID(s)11923
Cosmic ID(s)TNFRSF8
KEGG Gene ID(s)hsa:943
PharmGKB ID(s)PA36616
General Description of CD30 / TNFRSF8.
Recognizes a single chain glycoprotein of 105/120kDa, identified as CD30/Ki-1. CD30 is synthesized as a 90kDa precursor, which is processed in the Golgi complex into a membrane-bound phosphorylated mature 105/120kDa glycoprotein. In Hodgkin s disease, CD30/Ki-1 antigen is expressed by mononuclear-Hodgkin and multinucleated Reed-Sternberg cells. It is also expressed by the tumor cells of a majority of anaplastic large cell lymphomas as well as by a varying proportion of activated T and B cells. This MAb distinguishes large cell lymphomas derived from activated lymphoid cells from histiocytic malignancies and lymphomas derived from resting and precursor lymphoid cells or from anaplastic carcinomas. About one third of the Ki-1 positive lymphomas lack the leukocyte common antigen (CD45).

Human Anti-CD30 / TNFRSF8 Antibody Product Attributes

Species: Human
Tested Applications: Immunohistochemistry (IHC).
Clonality: Recombinant Monoclonal
Anti-CD30 / TNFRSF8 Antibody Clone: rKi-1/779
Clone rKi-1/779 Host and Isotype: Mouse IgG1 kappa
Anti-Human CD30 / TNFRSF8 Positive Control Sample: Hodgkin s lymphoma
Cellular Localization of Antibody Cell surface
Buffer and Stabilizer: 10mM PBS with or without 0.05% BSA & 0.05% azide.
Antibody Concentration: 200ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Recombinant full-length human TNFRSF8 protein
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.

CD30 / TNFRSF8 Previously Observed Antibody Staining Patterns

Observed Antibody Staining Data By Tissue Type:

Variations in CD30 / TNFRSF8 antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. Low, but measureable presence of CD30 / TNFRSF8 could be seen inlymphoid tissue in appendix, non-germinal center cells in the lymph node, germinal center cells in the tonsil and non-germinal center cells in the tonsil. We were unable to detect CD30 / TNFRSF8 in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.

Observed Antibody Staining Data By Tissue Disease Status:

Tissues from cancer patients, for instance, have their own distinct pattern of CD30 / TNFRSF8 expression as measured by anti-CD30 / TNFRSF8 antibody immunohistochemical staining. The average level of expression by tumor is summarized in the table below. The variability row represents patient to patient variability in IHC staining.

Sample Type breast cancer carcinoid cervical cancer colorectal cancer endometrial cancer glioma head and neck cancer liver cancer lung cancer lymphoma melanoma ovarian cancer pancreatic cancer prostate cancer renal cancer skin cancer stomach cancer testicular cancer thyroid cancer urothelial cancer
Signal Intensity - - + - - - + - - - - - - - - - - - - -
TNFRSF8 Variability + + ++ + ++ + +++ + ++ ++ ++ ++ + + + ++ + ++ ++ ++

Limitations and Warranty

enQuire Bio's CD30 / TNFRSF8 Recombinant Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

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Anti-CD30 / TNFRSF8 Antibody Clone rKi-1/779

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