Formalin-fixed, paraffin-embedded human Angiosarcoma stained with CD31 Recombinant Rabbit Monoclonal Antibody (C31/1395R).

Anti-CD31 / PECAM-1 Antibody Clone C31/1395R

Name: Anti-CD31 / PECAM-1 Antibody Clone C31/1395R
Brand: enQuire Bio
Price: 199 USD
Availability: InStock

$ 228.00 – $ 618.00

Please Select Product Options Below To View The Catalog Number.

SKU: 5175-RBM11
Species: Human
Tested Applications: Immunohistochemistry (IHC)
Available Conjugates: Unconjugated
Isotype: Rabbit IgG kappa
Mass Spec Validated?: Not MS Validated

Product Number	Description	Price
5175-RBM11-P0	Size: 20 ug, Tag: Unconjugated	$ 199.00
5175-RBM11-P1	Size: 100 ug, Tag: Unconjugated	$ 429.00
5175-RBM11-P2	Size: 200 ug, Tag: Unconjugated	$ 549.00

Shipping Information

In Stock.

Flat Rate Shipping Anywhere in the US: $45

Datasheets and Documentation

Product Datasheet

Certificate of Analysis and Tags (Coming Soon)

SKU: 5175-RBM11-P0

CD31 / PECAM-1 General Information
Alternate Names
Platelet endothelial cell adhesion molecule, PECAM-1, cluster of differentiation 31, CD31, PECAM
Molecular Weight
~100kDa (endothelium) and ~130kDa (platelets)
Chromosomal Location
17q23.3
Curated Database and Bioinformatic Data
Gene Symbol	PECAM1
Entrez Gene ID	5175
Ensemble Gene ID	ENSG00000261371
RefSeq Protein Accession(s)	XP_005276937, XP_016880229, NP_000433, XP_016880227, XP_016880228, XP_011523191, XP_005276938, XP_011523192, XP_005276939, XP_016880230, XP_005276940
RefSeq mRNA Accession(s)	XM_011524890, XM_017024739, NM_000442, XM_005276881, XM_017024738, XM_005276880, XM_005276882, XM_011524889, XM_005276883, XM_017024740
RefSeq Genomic Accession(s)	NG_047009, NC_000017, NC_018928
UniProt ID(s)	P16284, A0A075B738
UniGene ID(s)	P16284, A0A075B738
HGNC ID(s)	8823
Cosmic ID(s)	PECAM1
KEGG Gene ID(s)	hsa:5175
PharmGKB ID(s)	PA33167
General Description of CD31 / PECAM-1.
CD31 (PECAM-1) is a transmembrane glycoprotein member of the immunoglobulin supergene family of adhesion molecules. CD31 is expressed by stem cells of the hematopoietic system and is primarily used to identify and concentrate these cells for experimental studies as well as for bone marrow transplantation. Anti-CD31 has shown to be highly specific and sensitive for vascular endothelial cells. Staining of nonvascular tumors (excluding hematopoietic neoplasms) is rare. CD31 MAb reacts with normal, benign, and malignant endothelial cells which make up blood vessel lining. The level of CD31 expression can help to determine the degree of tumor angiogenesis, and a high level of CD31 expression may imply a rapidly growing tumor and potentially a predictor of tumor recurrence.

Human Anti-CD31 / PECAM-1 Antibody Product Attributes

Species: Human

Tested Applications: Immunohistochemistry (IHC).

Clonality: Recombinant Monoclonal

Anti-CD31 / PECAM-1 Antibody Clone: C31/1395R

Clone C31/1395R Host and Isotype: Rabbit IgG kappa

Anti-Human CD31 / PECAM-1 Positive Control Sample: Jurkat cells. Tonsil or Angiosarcoma.

Cellular Localization of Antibody Cell surface and cytoplasmic

Buffer and Stabilizer: 10mM PBS with or without 0.05% BSA & 0.05% azide.

Antibody Concentration: 200ug/ml

Antibody Purification Method:Protein A/G Purified

Immunogen: Human recombinant full-length CD31 protein

Storage Conditions: Store at 2 to 8Â° C (refrigerate). Stable for 24 months when properly stored.

CD31 / PECAM-1 Previously Observed Antibody Staining Patterns

Observed Antibody Staining Data By Tissue Type:

Variations in CD31 / PECAM-1 antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in endothelial cells in the colon, cells in the glomeruli in kidney, smooth muscle cells in the smooth muscle and cells in the red pulp in spleen. More moderate antibody staining intensity was present in endothelial cells in the colon, cells in the glomeruli in kidney, smooth muscle cells in the smooth muscle and cells in the red pulp in spleen. Low, but measureable presence of CD31 / PECAM-1 could be seen inmacrophages in lung. We were unable to detect CD31 / PECAM-1 in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.

Limitations and Warranty

enQuire Bio's CD31 / PECAM-1 Recombinant Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

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