Formalin-fixed, paraffin-embedded human Tonsil stained with CD35 Ab (E11).
Formalin-fixed, paraffin-embedded human Tonsil stained with CD35 Ab (E11).

Anti-CD35 / CR1 Antibody Clone E11

$ 298.00
Please Select Product Options Below To View The Catalog Number.

SKU: 1378-MSM1
Species: Human, Baboon, Cynomolgus Monkey, and Rhesus Monkey
Tested Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry (IHC)
Available Conjugates: Unconjugated
Isotype: Mouse IgG1 kappa
Mass Spec Validated?: Not MS Validated

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Datasheets and Documentation
Product Datasheet
SKU: 1378-MSM1-P1
CD35 / CR1 General Information
Alternate Names
Heart-type fatty acid binding protein, hFABP, FABP3, mammary derived growth inhibitor
Molecular Weight
210-220kDa
Chromosomal Location
1q32.2
Curated Database and Bioinformatic Data
Gene SymbolCR1
Entrez Gene ID1378
Ensemble Gene IDENSG00000203710
RefSeq Protein Accession(s)XP_006711229, XP_011507507, NP_000564, NP_000642
RefSeq mRNA Accession(s)XM_006711166 NM_000573, NM_000651, XM_011509205
RefSeq Genomic Accession(s)NC_018912, NC_000001, NG_007481
UniProt ID(s)E9PDY4, P17927
UniGene ID(s)E9PDY4, P17927
HGNC ID(s)2334
Cosmic ID(s)CR1
KEGG Gene ID(s)hsa:1378
PharmGKB ID(s)PA26855
General Description of CD35 / CR1.
Recognizes a protein of 210-220kDa, which is identified as the complement receptor 1 (CR1)/CD35. This MAb is specific for a site in CR1 that is distal from the C3b-binding site, so that it is unable to block CR1 activity. This MAb is highly specific to CR1, shows no cross-reaction with CR2. The primary function of CR1 is to serve as the cellular receptor for C3b, C4b, the most important components of the complement system leading to clearance of foreign macromolecules. The Knops blood group system is a system of antigens located on this protein. Follicular dendritic cells (FDC) are restricted to the B-cell regions of secondary lymphoid follicles. They are CD21+/CD35+/CD1a-. This MAb labels follicular dendritic cells, follicular dendritic cell sarcoma.

Human, Baboon, Cynomolgus Monkey, and Rhesus Monkey Anti-CD35 / CR1 Antibody Product Attributes

Species: Human, Baboon, Cynomolgus Monkey, and Rhesus Monkey
Tested Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry (IHC).
Application Notes: Flow Cytometry (0.5-1ug of antibody/million cells in 0.1ml), Immunofluorescence (1-2ug of antibody/ml), Immunohistochemistry (IHC) (Formalin-fixed) (0.5-1ug of antibody/ml for 30 minutes at RT)
Clonality: Monoclonal
Anti-CD35 / CR1 Antibody Clone: E11
Clone E11 Host and Isotype: Mouse IgG1 kappa
Anti-Human, Baboon, Cynomolgus Monkey, and Rhesus Monkey CD35 / CR1 Positive Control Sample: Follicular dendritic cells (FDC) in tonsil
Cellular Localization of Antibody Cell surface
Buffer and Stabilizer: 10mM PBS with 0.05% BSA & 0.05% azide.
Antibody Concentration: 200ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Intact human monocytes
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.

CD35 / CR1 Previously Observed Antibody Staining Patterns

Observed Antibody Staining Data By Tissue Type:

Variations in CD35 / CR1 antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. Low, but measureable presence of CD35 / CR1 could be seen in cells in the red pulp in spleen. We were unable to detect CD35 / CR1 in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.

Limitations and Warranty

enQuire Bio's CD35 / CR1 Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

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