Formalin-fixed, paraffin-embedded human Tonsil stained with CD3 epsilon Monoclonal Antibody (PC3/188A).
Formalin-fixed, paraffin-embedded human Tonsil stained with CD3 epsilon Monoclonal Antibody (PC3/188A).

Anti-CD3e Antibody Clone PC3/188A

$ 228.00$ 518.00
Please Select Product Options Below To View The Catalog Number.

SKU: 916-MSM10
Species: Human
Tested Applications: Immunohistochemistry (IHC)
Available Conjugates: Unconjugated
Isotype: Mouse IgG1
Mass Spec Validated?: Not MS Validated

Product NumberDescriptionPrice
916-MSM10-P0 Size: 20 ug, Tag: Unconjugated $ 199.00
916-MSM10-P1 Size: 100 ug, Tag: Unconjugated $ 429.00
916-MSM10-P2 Size: 200 ug, Tag: Unconjugated $ 459.00
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In Stock.
Flat Rate Shipping Anywhere in the US: $45
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SKU: 916-MSM10-P0
CD3e General Information
Alternate Names
CD3e molecule, Cluster of Differentiation 3E, Often just referred to as CD3
Molecular Weight
20kDa
Chromosomal Location
11q23.3
Curated Database and Bioinformatic Data
Gene SymbolCD3E
Entrez Gene ID916
Ensemble Gene IDENSG00000198851
RefSeq Protein Accession(s)NP_000724
RefSeq mRNA Accession(s)NM_000733,
RefSeq Genomic Accession(s)NC_018922, NG_007383, NC_000011
UniProt ID(s)P07766
UniGene ID(s)P07766
HGNC ID(s)1674
Cosmic ID(s)CD3E
KEGG Gene ID(s)hsa:916
PharmGKB ID(s)PA26216
General Description of CD3e.
Recognizes the ?-chain of CD3, which consists of five different polypeptide chains (designated as gamma, delta, epsilon, zeta, and eta) with MW ranging from 16-28kDa. The CD3 complex is closely associated at the lymphocyte cell surface with the T cell antigen receptor (TCR). Reportedly, CD3 complex is involved in signal transduction to the T cell interior following antigen recognition. The CD3 antigen is first detectable in early thymocytes and probably represents one of the earliest signs of commitment to the T cell lineage. In cortical thymocytes, CD3 is predominantly intra-cytoplasmic. However, in medullary thymocytes, it appears on the T cell surface. CD3 antigen is a highly specific marker for T cells, and is present in majority of T cell neoplasms.

Human Anti-CD3e Antibody Product Attributes

Species: Human
Tested Applications: Immunohistochemistry (IHC).
Clonality: Monoclonal
Anti-CD3e Antibody Clone: PC3/188A
Clone PC3/188A Host and Isotype: Mouse IgG1
Anti-Human CD3e Positive Control Sample: Jurkat cells. Tonsil and lymph node
Cellular Localization of Antibody Cell surface and cytoplasmic
Buffer and Stabilizer: 10mM PBS with 0.05% BSA and 0.05% Azide
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: A synthetic peptide corresponding to amino acids 156-168 of the cytoplasmic domain of human CD3-? chain
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.

CD3e Previously Observed Antibody Staining Patterns

Observed Antibody Staining Data By Tissue Type:

Variations in CD3e antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in lymphoid tissue in appendix and non-germinal center cells in the lymph node and tonsil. More moderate antibody staining intensity was present in lymphoid tissue in appendix and non-germinal center cells in the lymph node and tonsil. Low, but measureable presence of CD3e could be seen in. We were unable to detect CD3e in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.

Limitations and Warranty

enQuire Bio's CD3e Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

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Anti-CD3e Antibody Clone PC3/188A

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