Formalin-paraffin human Tongue Carcinoma stained with CD44v6 Monoclonal Antibody (CD44v6/1246)
Formalin-paraffin human Tongue Carcinoma stained with CD44v6 Monoclonal Antibody (CD44v6/1246)

Anti-CD44v6 Antibody Clone CD44v6/1246

$ 199.00$ 459.00
Please Select Product Options Below To View The Catalog Number.

SKU: 960-MSM7
Species: Human
Tested Applications: Immunohistochemistry (IHC)
Available Conjugates: Unconjugated
Isotype: Mouse IgG2a kappa
Mass Spec Validated?: Not MS Validated

Product NumberDescriptionPrice
960-MSM7-P0 Size: 20 ug, Tag: Unconjugated $ 199.00
960-MSM7-P1 Size: 100 ug, Tag: Unconjugated $ 429.00
960-MSM7-P2 Size: 200 ug, Tag: Unconjugated $ 459.00
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In Stock.
Flat Rate Shipping Anywhere in the US: $45
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SKU: 960-MSM7-P0
CD44v6 General Information
Alternate Names
CD44, Cluster of Differentiation 44
Molecular Weight
80-95kDa
Chromosomal Location
11p13
Curated Database and Bioinformatic Data
Gene SymbolCD44
Entrez Gene ID960
Ensemble Gene IDENSG00000026508
RefSeq Protein Accession(s)XP_005253290, XP_011518789, XP_011518790, XP_005253288, XP_011518784, XP_011518786, NP_001001391, XP_005253297, XP_006718451, XP_011518787, XP_011518791, NP_000601, NP_001001389, NP_001189486, XP_005253289, XP_011518788, NP_001001392, NP_001189484, XP_005253292, XP_005253295, XP_005253296, XP_011518785, NP_001001390, XP_005253291, XP_006718453, XP_016874072, XP_016874074, NP_001189485, XP_016874073
RefSeq mRNA Accession(s)NM_001202556, XM_005253235, XM_006718388, NM_001001389, NM_001001391, XM_011520489, XM_011520485, XM_011520487, XM_011520488, XM_017018584, XM_017018585, NM_001202555, XM_005253231, XM_005253232, XM_005253234, XM_006718390, XM_011520483, NM_001001392, NM_001202557, XM_005253238, XM_005253239, XM_005253240, NM_001001390, XM_005253233, XM_011520482, XM_011520484, XM_011520486, XM_017018583, NM_000610
RefSeq Genomic Accession(s)NG_008937, NC_000011, NC_018922
UniProt ID(s)P16070
UniGene ID(s)P16070
HGNC ID(s)1681
Cosmic ID(s)CD44
KEGG Gene ID(s)hsa:960
PharmGKB ID(s)PA26221
General Description of CD44v6.
This antibody recognizes an epitope encoded by exon v6 on the variant portion of human CD44. The CD44 molecule belongs to a family of cellular adhesion molecules found on a wide range of normal and malignant cells in epithelial, mesothelial and hemopoiesis tissues. CD44 is a single gene with 20 exons, of which 10 are normally expressed to encode the basic CD44 (H-CAM) molecule. The additional 10 exons (v1 to v10) are only expressed by alternative splicing of the nuclear RNA. The expression of specific cell adhesion molecule CD44 splice variants has been reported to be associated with metastasis in certain human malignancies.

Human Anti-CD44v6 Antibody Product Attributes

Species: Human
Tested Applications: Immunohistochemistry (IHC).
Clonality: Monoclonal
Anti-CD44v6 Antibody Clone: CD44v6/1246
Clone CD44v6/1246 Host and Isotype: Mouse IgG2a kappa
Anti-Human CD44v6 Positive Control Sample: Cervix or Tongue Squamous Cell Carcinoma
Cellular Localization of Antibody Cell surface
Buffer and Stabilizer: 10mM PBS with 0.05% BSA and 0.05% Azide
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Recombinant fragment corresponding to the v6 domain of human CD44
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.

CD44v6 Previously Observed Antibody Staining Patterns

Observed Subcellular, Organelle Specific Staining Data:

Anti-CD44 antibody staining is expected to be primarily localized to the golgi apparatus and plasma membrane. There is variability in either the signal strength or the localization of signal in golgi apparatus from cell to cell.

Observed Antibody Staining Data By Tissue Type:

Variations in CD44v6 antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in epidermal cells in the skin, glandular cells in the breast, cervix, uterine, prostate and salivary gland, hematopoietic cells in the bone marrow, keratinocytes in skin, Langerhans in skin, melanocytes in skin, respiratory epithelial cells in the bronchus and nasopharynx, squamous epithelial cells in the cervix, uterine, esophagus, oral mucosa, tonsil and vagina and urothelial cells in the urinary bladder. More moderate antibody staining intensity was present in epidermal cells in the skin, glandular cells in the breast, cervix, uterine, prostate and salivary gland, hematopoietic cells in the bone marrow, keratinocytes in skin, Langerhans in skin, melanocytes in skin, respiratory epithelial cells in the bronchus and nasopharynx, squamous epithelial cells in the cervix, uterine, esophagus, oral mucosa, tonsil and vagina and urothelial cells in the urinary bladder. Low, but measureable presence of CD44v6 could be seen inadipocytes in mesenchymal tissue, cells in the glomeruli in kidney, cells in the tubules in kidney, decidual cells in the placenta, endothelial cells in the cerebral cortex and colon, follicle cells in the ovary, glandular cells in the fallopian tube, rectum and seminal vesicle, Leydig cells in the testis, neuronal cells in the cerebral cortex, neuropil in cerebral cortex, pneumocytes in lung and trophoblastic cells in the placenta. We were unable to detect CD44v6 in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.

Observed Antibody Staining Data By Tissue Disease Status:

Tissues from cancer patients, for instance, have their own distinct pattern of CD44v6 expression as measured by anti-CD44v6 antibody immunohistochemical staining. The average level of expression by tumor is summarized in the table below. The variability row represents patient to patient variability in IHC staining.

Sample Type breast cancer carcinoid cervical cancer colorectal cancer endometrial cancer glioma head and neck cancer liver cancer lung cancer lymphoma melanoma ovarian cancer pancreatic cancer prostate cancer renal cancer skin cancer stomach cancer testicular cancer thyroid cancer urothelial cancer
Signal Intensity ++ - +++ ++ ++ +++ +++ + + +++ +++ + ++ ++ - ++ - - ++ -
CD44 Variability ++ + + ++ ++ ++ + ++ ++ ++ + ++ ++ ++ ++ ++ ++ ++ ++ ++

Limitations and Warranty

enQuire Bio's CD44v6 Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

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Anti-CD44v6 Antibody Clone CD44v6/1246

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