Human PBMCs were stained with FITC Human Anti-CD3  and 5 uL  (right panel) or 0.5 ug APC Mouse IgG1 isotype control (left panel).

Human Anti-CD56 / NCAM Antibody [MY31]

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Species: Human
Tested Applications: Flow Cytometry
Available Conjugates: PE ;APC ;FITC ;PE-Cy7
Isotype: Mouse IgG1 kappa
Mass Spec Validated?: Not MS Validated

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Datasheets and Documentation
Product Datasheet
SKU: QAB48-PE-25Tests
CD56 General Information
Alternate Names
NCAM, Neural Cell Adhesion Molecule
Curated Database and Bioinformatic Data
Gene SymbolNCAM1
Entrez Gene ID4684
Ensemble Gene IDENSG00000149294
RefSeq Protein Accession(s)NP_001229536, NP_851996, NP_001070150, NP_001229537, NP_000606
RefSeq mRNA Accession(s)NM_001076682, NM_001242607, NM_001242608, NM_181351 NM_000615
RefSeq Genomic Accession(s)NC_000011, NG_032036, NC_018922
UniProt ID(s)P13591, A0A087WWD4
UniGene ID(s)P13591, A0A087WWD4
HGNC ID(s)7656
Cosmic ID(s)NCAM1
KEGG Gene ID(s)hsa:4684
PharmGKB ID(s)PA31459
General Description of CD56.
The MY31 antibody reacts with human CD56, also known as the neural cell adhesion molecule (NCAM), a glycoprotein which is a member of the immunoglobulin superfamily. The 140 kDa isoform of CD56 is expressed on human NK cells and NK-T cells, with increased expression levels on activated NK lymphocytes. The CD56 antigen is also expressed by neurons and is reported to play a role in nervous system development and neural cell-to-cell adhesion. Clone MY31 also reacts with a subset of CD14+ monocytes in non-human primates, and is reported to be cross-reactive with Chimpanzee, Cynomolgus and Rhesus.

Human Anti-CD56 Antibody Product Attributes

Species: Human
Cross Reactivity: chimpanzee, cynomolgus monkey, rhesus macaque
Tested Applications: Flow Cytometry.
Application Notes: 5 ul per test where one test represents staining of a cell sample in a final volume of approximately 100 uL. The number of cells within a sample must be experimentally determined, but ranges between 1x105 to 1x108 cells.
Clonality: Monoclonal Antibody
Anti-CD56 Antibody Clone: MY31
Clone MY31 Host and Isotype: Mouse IgG1 kappa
Buffer and Stabilizer: 10 mM NaH2PO4, 150 mM NaCl, 0.09% NaN3, 0.1% gelatin, pH7.2
Antibody Concentration: 5 uL /test
Storage Conditions: 2-8C protected from light. Stable for 12 Months. Do Not Freeze.

CD56 Previously Observed Antibody Staining Patterns

Observed Subcellular, Organelle Specific Staining Data:

Staining with anti-CD56 antibody reveals CD56 expression is expected to be primarily localized to the cytosol and plasma membrane.

Observed Antibody Staining Data By Tissue Type:

Variations in CD56 antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in neuropil in cerebral cortex and peripheral nerve/ganglion in colon. More moderate antibody staining intensity was present in neuropil in cerebral cortex and peripheral nerve/ganglion in colon. Low, but measureable presence of CD56 could be seen inglial cells in the hippocampus, exocrine glandular cells in the pancreas and smooth muscle cells in the smooth muscle. We were unable to detect CD56 in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.

Observed Antibody Staining Data By Tissue Disease Status:

Tissues from cancer patients, for instance, have their own distinct pattern of CD56 expression as measured by anti-CD56 antibody immunohistochemical staining. The average level of expression by tumor is summarized in the table below. The variability row represents patient to patient variability in IHC staining.

Sample Type breast cancer carcinoid cervical cancer colorectal cancer endometrial cancer glioma head and neck cancer liver cancer lung cancer lymphoma melanoma ovarian cancer pancreatic cancer prostate cancer renal cancer skin cancer stomach cancer testicular cancer thyroid cancer urothelial cancer
Signal Intensity - - - - - ++ - - - - - - - - - - - - - -
NCAM1 Variability + ++ + + + ++ + + + + + ++ + + + + + + ++ +

Selected References

Lanier LL, Testi R, Bindl J and Phillips JH. 1989. J Exp Med. 169: 2233-2238.Schlossman SF, Boumsell L, Gilks W et al., eds. 1995. Leucocyte Typing V: White Cell Differentiation Antigens. Oxford University Press.Carter DL, Shieh TM, Blosser RL, Chadwick KR, Margolick JB, Hidreth JE, Clements JE and Zink MC. 1999. Cytometry. 37(1): 41-50.Chan WK, Suwannasaen D, Throm RE, Li Y, Eldridge PW, Houston J, Gray JT, Pui C-H and Leung W. 2015. Leukemia. 29: 387-395. (Flow cytometry)Woltman AM, Op den Brouw ML, Biesta PJ, Shi CC and Janssen HLA. 2011. PLoS ONE 6(1): e15324. doi: 10.1371/journal.pone.0015324. (Flow cytometry)Bleul CC, Wu L, Hoxie JA, Springer TA and Mackay CR. 1997. Proc Natl Acad Sci USA. 94(5): 1925-1930. (Flow cytometry)Brown K and Barratt-Boyes SM. 2009. J Med Primatol. 38(4): 272-278. (Flow cytometry - Rhesus)

Limitations and Warranty

enQuire Bio's Human Anti-CD56 / NCAM Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

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