Formalin-fixed, paraffin-embedded human Tonsil stained with CD6 Monoclonal Antibody (C6/372).
Formalin-fixed, paraffin-embedded human Tonsil stained with CD6 Monoclonal Antibody (C6/372).

Anti-CD6 Antibody Clone C6/372

$ 429.00
Please Select Product Options Below To View The Catalog Number.

SKU: 923-MSM2
Species: Human
Tested Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry (IHC)
Available Conjugates: Unconjugated
Isotype: Mouse IgG1
Mass Spec Validated?: Not MS Validated

Product NumberDescriptionPrice
923-MSM2-P1 Size: 100 ug, Tag: Unconjugated
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In Stock.
Flat Rate Shipping Anywhere in the US: $45
Datasheets and Documentation
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SKU: 923-MSM2-P1
CD6 General Information
Alternate Names
CD6, Cluster of Differentiation 6
Molecular Weight
90-130kDa
Chromosomal Location
11q12.2
Curated Database and Bioinformatic Data
Gene SymbolCD6
Entrez Gene ID923
Ensemble Gene IDENSG00000013725
RefSeq Protein Accession(s)XP_011543664, XP_006718803, XP_006718804, XP_011543662, NP_006716, NP_001241680, XP_006718802, XP_006718801, NP_001241679
RefSeq mRNA Accession(s)XM_011545362, NM_006725, XM_006718740, XM_011545360, XM_006718739, NM_001254751, NR_045638, XM_006718738, XM_006718741, NM_001254750
RefSeq Genomic Accession(s)NC_018922, NC_000011
UniProt ID(s)P30203, Q8N4Q7, Q6AZ88
UniGene ID(s)P30203, Q8N4Q7, Q6AZ88
HGNC ID(s)1691
Cosmic ID(s)CD6
KEGG Gene ID(s)hsa:923
PharmGKB ID(s)PA26230
General Description of CD6.
CD6 is a type I transmembrane glycoprotein that contains a 24-amino acid signal sequence, three extracellular scavenger receptor cysteine-rich (SRCR) domains, a membrane-spanning domain, a 44-amino acid cytoplasmic domain. The CD6 glycoprotein is tyrosine phosphorylated during TCR-mediated T cell activation. CD6 shows significant homology to CD5. CD6 is present on mature thymocytes, peripheral T cells, a subset of B cells. Antibodies to CD6 are used to deplete T cells from bone marrow transplants to prevent graft versus host disease.

Human Anti-CD6 Antibody Product Attributes

Species: Human
Tested Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry (IHC).
Application Notes: Flow Cytometry (0.5-1ug of antibody/million cells in 0.1ml), Immunofluorescence (0.5-1ug of antibody/ml), Immunohistochemistry (IHC) (Formalin-fixed) (0.5-1ug of antibody/ml for 30 minutes at RT)
Clonality: Monoclonal
Anti-CD6 Antibody Clone: C6/372
Clone C6/372 Host and Isotype: Mouse IgG1
Anti-Human CD6 Positive Control Sample: CCRF-CEM, Jurkat cells, Tonsil
Cellular Localization of Antibody Cell surface, Cytoplasmic
Buffer and Stabilizer: 10mM PBS with 0.05% BSA & 0.05% azide.
Antibody Concentration: 200ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Human recombinant CD6 protein
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.

CD6 Previously Observed Antibody Staining Patterns

Observed Antibody Staining Data By Tissue Type:

Variations in CD6 antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in cells in the white pulp in spleen, lymphoid tissue in appendix and non-germinal center cells in the lymph node and tonsil. More moderate antibody staining intensity was present in cells in the white pulp in spleen, lymphoid tissue in appendix and non-germinal center cells in the lymph node and tonsil. Low, but measureable presence of CD6 could be seen inhematopoietic cells in the bone marrow. We were unable to detect CD6 in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.

Observed Antibody Staining Data By Tissue Disease Status:

Tissues from cancer patients, for instance, have their own distinct pattern of CD6 expression as measured by anti-CD6 antibody immunohistochemical staining. The average level of expression by tumor is summarized in the table below. The variability row represents patient to patient variability in IHC staining.

Sample Type breast cancer carcinoid cervical cancer colorectal cancer endometrial cancer glioma head and neck cancer liver cancer lung cancer lymphoma melanoma ovarian cancer pancreatic cancer prostate cancer renal cancer skin cancer stomach cancer testicular cancer thyroid cancer urothelial cancer
Signal Intensity - - - - - - - - - - - - - - - - - - - -
CD6 Variability + + + + + + + + + ++ + + + + + + + + ++ +

Limitations and Warranty

enQuire Bio's CD6 Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

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Anti-CD6 Antibody Clone C6/372

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