Formalin-fixed, paraffin-embedded human Tonsil stained with CD68 Monoclonal Antibody (KP1).
Formalin-fixed, paraffin-embedded human Tonsil stained with CD68 Monoclonal Antibody (KP1).

Anti-CD68 Antibody Clone KP1

$ 429.00
Please Select Product Options Below To View The Catalog Number.

SKU: 968-MSM1
Species: Human, Monkey, Rabbit, Cat, Pig (-), Canine (-), and Chicken (-)
Tested Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry (IHC)
Available Conjugates: Unconjugated
Isotype: Mouse IgG1 kappa
Mass Spec Validated?: Not MS Validated

Product NumberDescriptionPrice
968-MSM1-P1 Size: 100 ug, Tag: Unconjugated
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SKU: 968-MSM1-P1
CD68 General Information
Alternate Names
CD68, Cluster of Differentiation 5, Macrosialin (mouse)
Molecular Weight
110kDa
Chromosomal Location
17p13.1
Curated Database and Bioinformatic Data
Gene SymbolCD68
Entrez Gene ID968
Ensemble Gene IDENSG00000129226
RefSeq Protein Accession(s)NP_001242, NP_001035148
RefSeq mRNA Accession(s)NM_001040059, NM_001251
RefSeq Genomic Accession(s)NC_000017, NG_009204, NC_018928
UniProt ID(s)P34810
UniGene ID(s)P34810
HGNC ID(s)1693
Cosmic ID(s)CD68
KEGG Gene ID(s)hsa:968
PharmGKB ID(s)PA26232
General Description of CD68.
This antibody recognizes a glycoprotein of 110kDa, which is identified as CD68. It is important for identifying macrophages in tissue sections. It stains macrophages in a wide variety of human tissues, including Kupffer cells, macrophages in the red pulp of the spleen, in lamina propria of the gut, in lung alveoli,, in bone marrow. It reacts with myeloid precursors, peripheral blood granulocytes. It also reacts with plasmacytoid T cells, which are supposed to be of monocyte/macrophage origin. It shows strong granular cytoplasmic staining of chronic, acute myeloid leukemia, also reacts with rare cases of true histiocytic neoplasia. Lymphomas are negative or show few granules.

Human, Monkey, Rabbit, Cat, Pig (-), Canine (-), and Chicken (-) Anti-CD68 Antibody Product Attributes

Species: Human, Monkey, Rabbit, Cat, Pig (-), Canine (-), and Chicken (-)
Tested Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry (IHC).
Application Notes: Flow Cytometry (0.5-1ug of antibody/million cells in 0.1ml), Immunofluorescence (0.5-1ug of antibody/ml), Immunohistochemistry (IHC) (Formalin-fixed) (0.25-0.5ug of antibody/ml for 30 minutes at RT)
Clonality: Monoclonal
Anti-CD68 Antibody Clone: KP1
Clone KP1 Host and Isotype: Mouse IgG1 kappa
Anti-Human, Monkey, Rabbit, Cat, Pig (-), Canine (-), and Chicken (-) CD68 Positive Control Sample: Tonsil, Lymph Node or Spleen
Cellular Localization of Antibody Cytoplasmic
Buffer and Stabilizer: 10mM PBS with 0.05% BSA & 0.05% azide.
Antibody Concentration: 200ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Subcellular fraction of human alveolar macrophages
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.

CD68 Previously Observed Antibody Staining Patterns

Observed Subcellular, Organelle Specific Staining Data:

Anti-CD68 antibody staining is expected to be primarily localized to the vesicles and golgi apparatus.

Observed Antibody Staining Data By Tissue Type:

Variations in CD68 antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in cells in the red pulp in spleen and macrophages in lung. More moderate antibody staining intensity was present in cells in the red pulp in spleen and macrophages in lung. Low, but measureable presence of CD68 could be seen inglial cells in the cerebral cortex. We were unable to detect CD68 in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.

Limitations and Warranty

enQuire Bio's CD68 Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

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Anti-CD68 Antibody Clone KP1

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