Formalin-fixed, paraffin-embedded human Tonsil stained with CD79a Monoclonal Antibody (HM57).
Formalin-fixed, paraffin-embedded human Tonsil stained with CD79a Monoclonal Antibody (HM57).

Anti-CD79a Antibody Clone HM57

$ 199.00$ 459.00
Please Select Product Options Below To View The Catalog Number.

SKU: 973-MSM7
Species: Human
Tested Applications: Immunohistochemistry (IHC)
Available Conjugates: Unconjugated
Isotype: Mouse IgG1 kappa
Mass Spec Validated?: Not MS Validated

Product NumberDescriptionPrice
973-MSM7-P0 Size: 20 ug, Tag: Unconjugated $ 228.00
973-MSM7-P1 Size: 100 ug, Tag: Unconjugated $ 488.00
973-MSM7-P2 Size: 200 ug, Tag: Unconjugated $ 518.00
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SKU: 973-MSM7-P0
CD79a General Information
Alternate Names
Cluster of differentiation CD79A, B-cell antigen receptor complex-associated protein alpha chain, MB-1 membrane glycoprotein, CD79A
Molecular Weight
Chromosomal Location
Curated Database and Bioinformatic Data
Gene SymbolCD79A
Entrez Gene ID973
Ensemble Gene IDENSG00000105369
RefSeq Protein Accession(s)NP_001774, NP_067612
RefSeq mRNA Accession(s)NM_021601, NM_001783,
RefSeq Genomic Accession(s)NG_009619, NC_018930, NC_000019
UniProt ID(s)P11912
UniGene ID(s)P11912
HGNC ID(s)1698
Cosmic ID(s)CD79A
KEGG Gene ID(s)hsa:973
PharmGKB ID(s)PA26237
General Description of CD79a.
A disulphide-linked heterodimer, consisting of mb-1 (or CD79a) and B29 (or CD79b) polypeptides, is non-covalently associated with membrane-bound immunoglobulins on B cells. This complex of mb-1 and B29 polypeptides and immunoglobulin constitute the B cell Ag receptor. CD79a first appears at pre B cell stage, early in maturation, and persists until the plasma cell stage where it is found as an intracellular component. CD79a is found in the majority of acute leukemias of precursor B cell type, in B cell lines, B cell lymphomas, and in some myelomas. It is not present in myeloid or T cell lines. Anti-CD79a is generally used to complement anti-CD20 especially for mature B-cell lymphomas after treatment with Rituximab (anti-CD20). This antibody will stain many of the same lymphomas as anti-CD20, but also is more likely to stain B-lymphoblastic lymphoma/leukemia than is anti-CD20. Anti-CD79a also stains more cases of plasma cell myeloma and occasionally some types of endothelial cells as well.

Human Anti-CD79a Antibody Product Attributes

Species: Human
Tested Applications: Immunohistochemistry (IHC).
Clonality: Monoclonal
Anti-CD79a Antibody Clone: HM57
Clone HM57 Host and Isotype: Mouse IgG1 kappa
Anti-Human CD79a Positive Control Sample: Daudi or Ramos cells. Germinal center B-cells in a lymph node or tonsil.
Cellular Localization of Antibody Cell surface
Buffer and Stabilizer: 10mM PBS with 0.05% BSA and 0.05% Azide
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: A synthetic peptide corresponding to aa 202-216 (GTYQDVGSLNIADVQ) of human CD79a protein.
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.

CD79a Previously Observed Antibody Staining Patterns

Observed Antibody Staining Data By Tissue Type:

Variations in CD79a antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in cells in the white pulp in spleen, germinal center cells in the lymph node, lymphoid tissue in appendix and non-germinal center cells in the tonsil. More moderate antibody staining intensity was present in cells in the white pulp in spleen, germinal center cells in the lymph node, lymphoid tissue in appendix and non-germinal center cells in the tonsil. Low, but measureable presence of CD79a could be seen inmacrophages in lung. We were unable to detect CD79a in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.

Limitations and Warranty

enQuire Bio's CD79a Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

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Anti-CD79a Antibody Clone HM57