Formalin-fixed, paraffin-embedded human Tonsil stained with CD81 Mouse Monoclonal Antibody (1.3.3.22).
Formalin-fixed, paraffin-embedded human Tonsil stained with CD81 Mouse Monoclonal Antibody (1.3.3.22).

Anti-CD81 / TAPA-1 Antibody Clone 1.3.3.22

$ 118.00$ 418.00
Please Select Product Options Below To View The Catalog Number.

SKU: 975-MSM1
Species: Human, Mouse, and Rat
Tested Applications: Immunohistochemistry (IHC)
Available Conjugates: Unconjugated
Isotype: Mouse IgG1 kappa
Mass Spec Validated?: Not MS Validated

Product NumberDescriptionPrice
975-MSM1-P0 Size: 20 ug, Tag: Unconjugated $ 118.00
975-MSM1-P1 Size: 100 ug, Tag: Unconjugated $ 298.00
975-MSM1-P2 Size: 200 ug, Tag: Unconjugated $ 418.00
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In Stock.
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SKU: 975-MSM1-P0
CD81 / TAPA-1 General Information
Alternate Names
CD81 molecule, CD81, Cluster of Differentiation 81
Molecular Weight
26kDa
Chromosomal Location
11p15.5
Curated Database and Bioinformatic Data
Gene SymbolCD81
Entrez Gene ID975
Ensemble Gene IDENSG00000110651
RefSeq Protein Accession(s)NP_004347, XP_011518794, XP_016874087, NP_001284578
RefSeq mRNA Accession(s)NM_001297649, NM_004356, XM_011520492
RefSeq Genomic Accession(s)NG_023386, NC_000011, NC_018922
UniProt ID(s)P18582, A0A024RCB7, P60033, E9PJK1
UniGene ID(s)P18582, A0A024RCB7, P60033, E9PJK1
HGNC ID(s)1701
Cosmic ID(s)CD81
KEGG Gene ID(s)hsa:975
PharmGKB ID(s)PA26240
General Description of CD81 / TAPA-1.
Recognizes a protein of 26kDa, identified as CD81 (Workshop VI ;Code CD81.1)). CD81 has a very broad cellular distribution, being expressed on T- and B-lymphocytes, NK cells, thymocytes, eosinophils, fibroblasts, epithelial and endothelial cells. Neutrophils, erythrocytes and platelets are negative, while monocytes are variably positive. CD81 is a member of a family of tetraspans transmembrane proteins, including CD9, CD37, CD53, CD63, and CD82. It associates with CD19, CD21, Leu 13, and integrins on cell membrane and is involved in signal transduction in B lymphocyte development and cell adhesion. CD81 also acts as a receptor for the envelope protein E2 of chronic hepatitis C virus. Antibodies to CD81 have anti-proliferative effects on different lymphoid cell lines, particularly those derived from large cell lymphomas.

Human, Mouse, and Rat Anti-CD81 / TAPA-1 Antibody Product Attributes

Species: Human, Mouse, and Rat
Tested Applications: Immunohistochemistry (IHC).
Clonality: Monoclonal
Anti-CD81 / TAPA-1 Antibody Clone: 1.3.3.22
Clone 1.3.3.22 Host and Isotype: Mouse IgG1 kappa
Anti-Human, Mouse, and Rat CD81 / TAPA-1 Positive Control Sample: Ramos, Daudi, Raji, U266, HUT-78, HUT-102, Jurkat, HL-60, KG1a, A293, A431, MG63, and human lymphocytes. Tonsil or Liver.
Cellular Localization of Antibody Cell surface
Buffer and Stabilizer: 10mM PBS with 0.05% BSA and 0.05% Azide
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: B-Cell line derived from a Burkitt lymphoma
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.

CD81 / TAPA-1 Previously Observed Antibody Staining Patterns

Observed Subcellular, Organelle Specific Staining Data:

Anti-CD81 antibody staining is expected to be primarily localized to the plasma membrane.

Observed Antibody Staining Data By Tissue Type:

Variations in CD81 / TAPA-1 antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in cells in the endometrial stroma in endometrium, cells in the seminiferous ducts in testis, germinal center cells in the tonsil and ovarian stroma cells in the ovary. More moderate antibody staining intensity was present in cells in the endometrial stroma in endometrium, cells in the seminiferous ducts in testis, germinal center cells in the tonsil and ovarian stroma cells in the ovary. Low, but measureable presence of CD81 / TAPA-1 could be seen inadipocytes in mesenchymal tissue, cells in the red pulp in spleen, exocrine glandular cells in the pancreas, glandular cells in the seminal vesicle, hematopoietic cells in the bone marrow, islets of Langerhans in pancreas, keratinocytes in skin, melanocytes in skin, myocytes in heart muscle and non-germinal center cells in the tonsil. We were unable to detect CD81 / TAPA-1 in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.

Observed Antibody Staining Data By Tissue Disease Status:

Tissues from cancer patients, for instance, have their own distinct pattern of CD81 / TAPA-1 expression as measured by anti-CD81 / TAPA-1 antibody immunohistochemical staining. The average level of expression by tumor is summarized in the table below. The variability row represents patient to patient variability in IHC staining.

Sample Type breast cancer carcinoid cervical cancer colorectal cancer endometrial cancer glioma head and neck cancer liver cancer lung cancer lymphoma melanoma ovarian cancer pancreatic cancer prostate cancer renal cancer skin cancer stomach cancer testicular cancer thyroid cancer urothelial cancer
Signal Intensity - - - - - - - - - + - - - - - - - - - -
CD81 Variability + + + + ++ ++ + ++ + ++ ++ ++ + + ++ + + ++ ++ +

Limitations and Warranty

enQuire Bio's CD81 / TAPA-1 Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

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Anti-CD81 / TAPA-1 Antibody Clone 1.3.3.22

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