Anti-CD8A Antibody Clone C8/468

$ 429.00
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SKU: 925-MSM1
Species: Human
Tested Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry (IHC)
Available Conjugates: Unconjugated
Isotype: Mouse IgG1 kappa
Mass Spec Validated?: Not MS Validated

Product NumberDescriptionPrice
925-MSM1-P1 Size: 100 ug, Tag: Unconjugated
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SKU: 925-MSM1-P1
CD8A General Information
Alternate Names
CD8a, Cluster of Differentiation 8a, Often just referred to as CD8
Molecular Weight
Chromosomal Location
Curated Database and Bioinformatic Data
Gene SymbolCD8A
Entrez Gene ID925
Ensemble Gene IDENSG00000153563
RefSeq Protein Accession(s)NP_001759, NP_001139345, NP_741969
RefSeq mRNA Accession(s)NM_001145873, NM_001768, NM_171827, NR_027353,
RefSeq Genomic Accession(s)NC_000002, NG_011608, NC_018913
UniProt ID(s)P01732, Q8TAW8, Q6ZVS2
UniGene ID(s)P01732, Q8TAW8, Q6ZVS2
HGNC ID(s)1706
Cosmic ID(s)CD8A
KEGG Gene ID(s)hsa:925
PharmGKB ID(s)PA26244
General Description of CD8A.
CD8 is a cell surface receptor expressed either as a heterodimer with the CD8 beta chain (CD8 alpha/beta) or as a homodimer (CD8 alpha/alpha). A majority of thymocytes, a subpopulation of mature T cells, NK cells express CD8a. CD8 binds to MHC class 1, through its association with protein tyrosine kinase p56lck plays a role in T cell development, activation of mature T cells. For mature T-cells, CD4, CD8 are mutually exclusive, so anti-CD8, generally used in conjunction with anti-CD4. It is a useful marker for distinguishing helper/inducer T-lymphocytes,, most peripheral T-cell lymphomas are CD4+/CD8-. Anaplastic large cell lymphoma is usually CD4+, CD8-,, in T-lymphoblastic lymphoma/leukemia, CD4, CD8 are often co-expressed. CD8 is also found in littoral cell angioma of the spleen.

Human Anti-CD8A Antibody Product Attributes

Species: Human
Tested Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry (IHC).
Application Notes: Flow Cytometry (0.5-1ug of antibody/million cells in 0.1ml), Immunofluorescence (0.5-1ug of antibody/ml), Immunohistochemistry (IHC) (Formalin-fixed) (0.5-1ug of antibody/ml for 30 minutes at RT)
Clonality: Monoclonal
Anti-CD8A Antibody Clone: C8/468
Clone C8/468 Host and Isotype: Mouse IgG1 kappa
Anti-Human CD8A Positive Control Sample: HuT78 or hPBL. Tonsil
Cellular Localization of Antibody Cell surface
Buffer and Stabilizer: 10mM PBS with 0.05% BSA & 0.05% azide.
Antibody Concentration: 200ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Human CD8 recombinant protein
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.

CD8A Previously Observed Antibody Staining Patterns

Observed Antibody Staining Data By Tissue Type:

Variations in CD8A antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in cells in the red pulp in spleen, cells in the white pulp in spleen, lymphoid tissue in appendix and non-germinal center cells in the lymph node and tonsil. More moderate antibody staining intensity was present in cells in the red pulp in spleen, cells in the white pulp in spleen, lymphoid tissue in appendix and non-germinal center cells in the lymph node and tonsil. Low, but measureable presence of CD8A could be seen inmacrophages in lung. We were unable to detect CD8A in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.

Limitations and Warranty

enQuire Bio's CD8A Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

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Anti-CD8A Antibody Clone C8/468