Formalin-fixed, paraffin-embedded Human Colon Carcinoma stained with CDX2 Mouse Monoclonal Antibody (CDX2/169).
Formalin-fixed, paraffin-embedded Human Colon Carcinoma stained with CDX2 Mouse Monoclonal Antibody (CDX2/169).

Anti-CDX2 Antibody Clone CDX2/1690

$ 118.00$ 418.00
Please Select Product Options Below To View The Catalog Number.

SKU: 1045-MSM1
Species: Human
Tested Applications: Immunohistochemistry (IHC)
Available Conjugates: Unconjugated
Isotype: Mouse IgG2a kappa
Mass Spec Validated?: Not MS Validated

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Datasheets and Documentation
Product Datasheet
SKU: 1045-MSM1-P0
CDX2 General Information
Alternate Names
Homeobox protein CDX-2, CDX2
Molecular Weight
40kDa
Chromosomal Location
13q12.2
Curated Database and Bioinformatic Data
Gene SymbolCDX2
Entrez Gene ID1045
Ensemble Gene IDENSG00000165556
RefSeq Protein Accession(s)XP_011533179, XP_011533181, NP_001256, NP_001341629, XP_011533177, XP_011533180, XP_011533178
RefSeq mRNA Accession(s)XM_011534875, XM_011534878, NM_001265, XM_011534876, XM_011534879, XM_011534877, NM_001354700
RefSeq Genomic Accession(s)NC_018924, NC_000013,
UniProt ID(s)Q99626
UniGene ID(s)Q99626
HGNC ID(s)1806
Cosmic ID(s)CDX2
KEGG Gene ID(s)hsa:1045
PharmGKB ID(s)PA26352
General Description of CDX2.
The intestine-specific transcription factors CDX1 and CDX2 are important for directing intestinal development, differentiation, proliferation and maintenance of the intestinal phenotype. CDX2 protein expression has been seen in GI carcinomas. Anti-CDX2 has been useful to establish GI origin of metastatic adenocarcinomas and carcinoids and is especially useful to distinguish metastatic colorectal adenocarcinoma from lung adenocarcinoma. However, mucinous carcinomas of the ovary also express CDX2 protein. It limits the usefulness of this marker in the distinction of metastatic colorectal adenocarcinoma from mucinous carcinoma of the ovary.

Human Anti-CDX2 Antibody Product Attributes

Species: Human
Tested Applications: Immunohistochemistry (IHC).
Clonality: Monoclonal
Anti-CDX2 Antibody Clone: CDX2/1690
Clone CDX2/1690 Host and Isotype: Mouse IgG2a kappa
Anti-Human CDX2 Positive Control Sample: HT29 cells or Colon Carcinoma
Cellular Localization of Antibody Nuclear
Buffer and Stabilizer: 10mM PBS with 0.05% BSA and 0.05% Azide
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Recombinant human CDX2 protein fragment (aa150-249)
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.

CDX2 Previously Observed Antibody Staining Patterns

Observed Subcellular, Organelle Specific Staining Data:

Anti-CDX2 antibody staining is expected to be primarily localized to the nucleoplasm. There is variability in either the signal strength or the localization of signal in nucleoplasm from cell to cell.

Observed Antibody Staining Data By Tissue Type:

Variations in CDX2 antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in glandular cells in the appendix, colon, duodenum, rectum. More moderate antibody staining intensity was present in glandular cells in the appendix, colon, duodenum, rectum. Low, but measureable presence of CDX2 could be seen in. We were unable to detect CDX2 in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.

Limitations and Warranty

enQuire Bio's CDX2 Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

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