Immunohistochemical staining of CDX2  of human FFPE tissue followed by incubation with HRP labeled secondary and development with DAB substrate.

DISC: CDX2 [AMT28 ] Antibody

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Species: Human
Tested Applications: IHC [IVD]
Available Conjugates:
Isotype: Mouse IgG1, kappa

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Datasheets and Documentation
Product Datasheet
Certificate of Analysis and Tags (Coming Soon)
Lot Number:

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Bioactivity (test results eg. IU/ml):

SKU: QIVD95-0.1ml
CDX2 General Information
Alternate Names
Molecular Weight
33.5 kDa
Chromosomal Location
q12.2 [chr: 13] [chr_start: 27962137] [chr_end: 27971139] [strand: -1]
Curated Database and Bioinformatic Data
Gene Symbol CDX2
Entrez Gene ID 1045
RefSeq Protein Accession(s) NP_001256
RefSeq mRNA Accession(s) XM_011534875; XM_011534878; NM_001265; XM_011534876; XM_011534879; NM_001354700
RefSeq Genomic Accession(s) NC_000013
UniProt ID(s) Q99626
PharmGKB ID(s) PA26352
KEGG Gene ID(s) hsa:1045
General Description of CDX2 .
Cdx2 is a caudal type homeobox gene that encodes an intestine-specific transcription factor that is expressed early in intestinal development and may be involved in the regulation of proliferation and differentiation of intestinal epithelial cells. It is expressed in the nuclei of epithelial cells throughout the intestine, from duodenum to rectum. The cdx2 protein is expressed in primary and metastatic colorectal carcinomas and has also been demonstrated in the intestinal metaplasia of the stomach and intestinal-type gastric cancer, while it is not expressed in the normal gastric mucosa. Studies have shown that cdx2 is superior marker compared to CK20.


Antibody (Suitable for clinical applications)

Sample Type: FFPE Patient Samples.
Tested Applications: IHC. Approved for In Vitro Diagnostic Procedures on FFPE tissues. For tissue collection recommendations, please see datasheet sent with product.
Application Notes
Specification Recommendation
Recommended Dilution (Conc) 1:10-1:25
Pretreatment EDTA Buffer pH 8.0
Incubation Parameters 30 min at Room Temperature
Prior to use, inspect vial for the presence of any precipitate or other unusual physical properties. These can indicate that the antibody has degraded and is no longer suitable for patient samples. Please run positive and negative controls simultaneously with all patient samples to account and control for errors in laboratory procedure. Use of methods or materials not recommended by enQuire Bio including change to dilution range and detection system should be routinely validated by the user.
Clonality: Monoclonal
Anti-CDX2 Antibody Clone: AMT28
Host and Isotype: Mouse IgG1, kappa
Recommended Positive Control Sample: Colon carcinoma
Cellular Localization of Antibody AMT28 Staining: Nuclear
Buffer and Stabilizer: PBS with 1% BSA and 0.05% NaN3
Antibody Concentration: Lot specific. Plese contact tech support for data.
Immunogen: Prokaryotic recombinant protein corresponding to the 180 amino acid N-terminal region of the human cdx2 molecule.
Storage Conditions: This antibody should be stored refrigerated (2-8°C). This product should not be used past the expiration date printed on the vial.

CDX2 Information for Pathologists


Homeobox gene that encodes a nuclear transcription factor critical for intestinal embryonic development; relatively specific for intestinal epithelium (but see positive staining below). Terminology Also called caudal-related homeobox gene 2, caudal type homeobox transcription factor 2. Homologue of Drosophila melanogaster homeobox gene-caudal. Uses by pathologists

Common Uses By Pathologists:

Fairly specific marker of GI origin for adenocarcinomas, but also stains selected adenocarcinomas of other sites indicated below (Am J Surg Pathol 2003;27:303); can use to determine origin of metastatic adenocarcinoma as part of panel (Arch Pathol Lab Med 2007;131:1561). Distinguish primary and secondary colorectal adenocarcinomas (Arch Pathol Lab Med 2005;129:920). Distinguish primary bladder adenocarcinoma (CDX2-, villin-) from colorectal carcinoma extending / metastatic to bladder (CDX2+, villin+, Mod Pathol 2005;18:1217). Distinguish mucinous bronchioloalveolar adenocarcinoma (CDX2-) from metastatic mucinous colorectal adenocarcinoma (CDX2+, Am J Clin Pathol 2004;122:421). Microscopic (histologic) images

Limitations and Warranty

This antibody is manufactured in accordance with clinical good manufacturing practices in an ISO13485:2016 certified production facility. It is intended for multiple uses including in vitro diagnostic use and research use only applications. Please see vial label for expiration date. We strive to always deliver antibodies with a shelf life of at least two years.

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DISC: CDX2 [AMT28 ] Antibody