Immunohistochemical staining of Cdx2  of human FFPE tissue followed by incubation with HRP labeled secondary and development with DAB substrate.

Cdx2 [EP25] Antibody (cGMP).

$ 158.00$ 948.00
Please Select Product Options Below To View The Catalog Number.

SKU: QIVD98
Species: Human
Tested Applications: IHC [IVD]
Available Conjugates:
Isotype: Rabbit Rabbit IgG

Product NumberDescriptionPrice
QIVD98-0.1ml Size: 0.1 ml, Format: Concentrate $ 158.00
QIVD98-0.5ml Size: 0.5 ml, Format: Concentrate $ 608.00
QIVD98-1ml Size: 1 ml, Format: Concentrate $ 948.00
QIVD98-6ml Size: 6 ml, Format: Predilute $ 368.00
Shipping Information
In Stock
Flat Rate Shipping Anywhere in the US: $45
Datasheets and Documentation
Product Datasheet
Certificate of Analysis and Tags (Coming Soon)
Lot Number:

Expiration Date:

Concentration (Write Lyophilized if Lyophilized):

Reconsitution Instructions (Leave Blank if Liquid):

Manufacture Date:

Purity:

Bioactivity (test results eg. IU/ml):


SKU: QIVD98-0.1ml
Cdx2 General Information
Alternate Names
Molecular Weight
33.5 kDa
Chromosomal Location
q12.2 [chr: 13] [chr_start: 27962137] [chr_end: 27971139] [strand: -1]
Curated Database and Bioinformatic Data
Gene SymbolCDX2
Entrez Gene ID1045
RefSeq Protein Accession(s)NP_001256
RefSeq mRNA Accession(s)XM_011534875; XM_011534878; NM_001265; XM_011534876; XM_011534879; NM_001354700
RefSeq Genomic Accession(s)NC_000013
UniProt ID(s)Q99626
PharmGKB ID(s)PA26352
KEGG Gene ID(s)hsa:1045
General Description of Cdx2 .
The caudal-related homeodomain protein 2, CDX-2, is a transcription factor which is expressed in the intestine and is thought to play an important role in the proliferation and differentiation of intestinal epithelial cells. The CDX-2 protein is expressed in primary and metastatic colorectal carcinomas, intestinal metaplasia of the stomach and intestinal type gastric cancer. In human colorectal cancer, the expression of both CDX2 and carbonic anhydrase 1, a gene regulated by CDX2, is reduced or absent. CDX-2 is one of the important regulators in defining pathways for coordinate control of drug metabolism in the gastrointestinal tract.

Antibody (Suitable for clinical applications)

Sample Type: FFPE Patient Samples.
Tested Applications: IHC. Approved for In Vitro Diagnostic Procedures on FFPE tissues. For tissue collection recommendations, please see datasheet sent with product.
Application Notes
Specification Recommendation
Recommended Dilution (Conc) 1:50-1:100
Pretreatment EDTA Buffer pH 8.0
Incubation Parameters 30 min at Room Temperature

Prior to use, inspect vial for the presence of any precipitate or other unusual physical properties. These can indicate that the antibody has degraded and is no longer suitable for patient samples. Please run positive and negative controls simultaneously with all patient samples to account and control for errors in laboratory procedure. Use of methods or materials not recommended by enQuire Bio including change to dilution range and detection system should be routinely validated by the user.

Clonality: Monoclonal
Anti-Cdx2 Antibody Clone: EP25
Host and Isotype: Rabbit Rabbit IgG
Recommended Positive Control Sample: Colon Colon Adenocarcinoma
Cellular Localization of Antibody EP25 Staining: Nuclear
Buffer and Stabilizer: PBS with 1% BSA and 0.05% NaN3
Antibody Concentration: Lot specific. Plese contact tech support for data.
Immunogen: A synthetic peptide corresponding to residues near the C-term of humanCDX-2 protein
Storage Conditions: This antibody should be stored refrigerated (2-8°C). This product should not be used past the expiration date printed on the vial.

Cdx2 Information for Pathologists

Summary:

Homeobox gene that encodes a nuclear transcription factor critical for intestinal embryonic development; relatively specific for intestinal epithelium (but see positive staining below). Terminology Also called caudal-related homeobox gene 2, caudal type homeobox transcription factor 2. Homologue of Drosophila melanogaster homeobox gene-caudal. Uses by pathologists

Common Uses By Pathologists:

Fairly specific marker of GI origin for adenocarcinomas, but also stains selected adenocarcinomas of other sites indicated below (Am J Surg Pathol 2003;27:303); can use to determine origin of metastatic adenocarcinoma as part of panel (Arch Pathol Lab Med 2007;131:1561). Distinguish primary and secondary colorectal adenocarcinomas (Arch Pathol Lab Med 2005;129:920). Distinguish primary bladder adenocarcinoma (CDX2-, villin-) from colorectal carcinoma extending / metastatic to bladder (CDX2+, villin+, Mod Pathol 2005;18:1217). Distinguish mucinous bronchioloalveolar adenocarcinoma (CDX2-) from metastatic mucinous colorectal adenocarcinoma (CDX2+, Am J Clin Pathol 2004;122:421). Microscopic (histologic) images

Limitations and Warranty

This antibody is manufactured in accordance with clinical good manufacturing practices in an ISO13485:2016 certified production facility. It is intended for multiple uses including in vitro diagnostic use and research use only applications. Please see vial label for expiration date. We strive to always deliver antibodies with a shelf life of at least two years.

There are no reviews yet.

Be the first to review “Cdx2 [EP25] Antibody (cGMP).”

Your email address will not be published. Required fields are marked *

Share a Protocol (View Reviewed Protocols Below)

Protocol Title

Materials

Methods

Notes


  protocol submission gif
enQuire Bio, LLC   8420 S Continental Divide Rd, #202   Littleton, CO 80127
Phone: 1-855-344-1400 | enquire@enquirebio.com | Fax: 1-720-897-3730
Customer Service Available M-F 8AM-6PM MST or 24/7 Via Email

Cdx2 [EP25] Antibody (cGMP).