Formalin-fixed, paraffin-embedded Rat Pancreas stained with CELA3B Monoclonal Antibody (CELA3B/1257).
Formalin-fixed, paraffin-embedded Rat Pancreas stained with CELA3B Monoclonal Antibody (CELA3B/1257).Formalin-fixed, paraffin-embedded Mouse Pancreas stained with CELA3B Monoclonal Antibody (CELA3B/1257).

Anti-CELA3B / ELA3B Antibody Clone CELA3B/1257

$ 118.00$ 418.00
Please Select Product Options Below To View The Catalog Number.

SKU: 23436-MSM2
Species: Human, Mouse, and Rat
Tested Applications: Immunohistochemistry (IHC)
Available Conjugates: Unconjugated
Isotype: Mouse IgG1
Mass Spec Validated?: Not MS Validated

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Datasheets and Documentation
Product Datasheet
SKU: 23436-MSM2-P0
CELA3B / ELA3B General Information
Alternate Names
Chymotrypsin-like elastase family member 3B, elastase-3B, protease E, fecal elastase
Molecular Weight
17kDa
Chromosomal Location
1p36.12
Curated Database and Bioinformatic Data
Gene SymbolCELA3B
Entrez Gene ID23436
Ensemble Gene IDENSG00000219073
RefSeq Protein Accession(s)NP_031378
RefSeq mRNA Accession(s)NM_007352
RefSeq Genomic Accession(s)NC_000001, NC_018912
UniProt ID(s)P08861
UniGene ID(s)P08861
HGNC ID(s)15945
Cosmic ID(s)CELA3B
KEGG Gene ID(s)hsa:23436
PharmGKB ID(s)PA27737
General Description of CELA3B / ELA3B.
This MAb recognizes a protein of ~30kDa, identified as CELA3B (Chymotrypsin like elastase family member 3B). Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, elastase 3B has little elastolytic activity. Like most of the human elastases, elastase 3B is secreted from the pancreas as a zymogen and, like other serine proteases such as trypsin, chymotrypsin and kallikrein ;it has a digestive function in the intestine. Elastase 3B preferentially cleaves proteins after alanine residues. Elastase 3B may also function in the intestinal transport and metabolism of cholesterol. Both elastase 3A and elastase 3B have been referred to as protease E and as elastase 1, and excretion of this protein in fecal material is frequently used as a measure of pancreatic function in clinical assays.

Human, Mouse, and Rat Anti-CELA3B / ELA3B Antibody Product Attributes

Species: Human, Mouse, and Rat
Tested Applications: Immunohistochemistry (IHC).
Clonality: Monoclonal
Anti-CELA3B / ELA3B Antibody Clone: CELA3B/1257
Clone CELA3B/1257 Host and Isotype: Mouse IgG1
Anti-Human, Mouse, and Rat CELA3B / ELA3B Positive Control Sample: Panc-28 or PANC1 cells. Pancreas
Cellular Localization of Antibody Cytoplasmic
Buffer and Stabilizer: 10mM PBS with 0.05% BSA and 0.05% Azide
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Recombinant human CELA3B protein fragment (aa82-238)
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.

CELA3B / ELA3B Previously Observed Antibody Staining Patterns

Observed Subcellular, Organelle Specific Staining Data:

Anti-CELA3B antibody staining is expected to be primarily localized to the cytosol.

Limitations and Warranty

enQuire Bio's CELA3B / ELA3B Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

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