Formalin-fixed, paraffin-embedded Human Pancreas stained with CFTR Monoclonal Antibody (SPM176).

Anti-CFTR Antibody Clone SPM176

$ 129.00$ 459.00
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SKU: 1080-MSM2X
Species: Human and Mouse
Tested Applications: Immunohistochemistry (IHC)
Available Conjugates: Unconjugated
Isotype: Mouse IgG2a
Mass Spec Validated?: Not MS Validated

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Datasheets and Documentation
Product Datasheet
SKU: 1080-MSM2X-P0
CFTR General Information
Alternate Names
Cystic fibrosis transmembrane conductance regulator, CFTR
Molecular Weight
165-170kDa
Chromosomal Location
7q31.2
Curated Database and Bioinformatic Data
Gene SymbolCFTR
Entrez Gene ID1080
Ensemble Gene IDENSG00000001626
RefSeq Protein Accession(s)XP_011514055, NP_000483, XP_016867188, XP_011514053, XP_011514056
RefSeq mRNA Accession(s)XM_011515753, XM_017011699, XM_011515754, NM_000492
RefSeq Genomic Accession(s)NG_016465, NC_018918, NC_000007
UniProt ID(s)A0A024R730, P13569
UniGene ID(s)A0A024R730, P13569
HGNC ID(s)1884
Cosmic ID(s)CFTR
KEGG Gene ID(s)hsa:1080
PharmGKB ID(s)PA109
General Description of CFTR.
Recognizes a protein of 165-170kDa, identified as cystic fibrosis transmembrane conductance regulator (CFTR). CFTR is composed of two membrane-spanning domains (MSD), two nucleotide-binding domains (NBD), and an R domain. It is structurally similar to multidrug resistance (Mdr1) protein and both are members of the superfamily of ATP-binding cassette (ABC) transporters, also known as traffic ATPases, which are implicated in the movement of various substrates. The CFTR protein is a small conductance adenosine 3',5'-cyclic monophosphate (cAMP)-activated chloride ion channel found in the apical membranes of epithelia within the pancreas, airway, intestine, bile duct, sweat gland, and male genital ducts. CFTR is a valuable marker of human pancreatic duct cell development and differentiation.

Human and Mouse Anti-CFTR Antibody Product Attributes

Species: Human and Mouse
Tested Applications: Immunohistochemistry (IHC).
Clonality: Monoclonal
Anti-CFTR Antibody Clone: SPM176
Clone SPM176 Host and Isotype: Mouse IgG2a
Anti-Human and Mouse CFTR Positive Control Sample: MOLT-4 cells. Pancreas, Kidney or Placenta.
Cellular Localization of Antibody Cell Surface and Cytoplasmic
Buffer and Stabilizer: 10mM PBS with 0.05% BSA and 0.05% Azide
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Recombinant human full-length CFTR
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.

CFTR Previously Observed Antibody Staining Patterns

Observed Antibody Staining Data By Tissue Type:

Variations in CFTR antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. Low, but measureable presence of CFTR could be seen inglandular cells in the salivary gland. We were unable to detect CFTR in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.

Observed Antibody Staining Data By Tissue Disease Status:

Tissues from cancer patients, for instance, have their own distinct pattern of CFTR expression as measured by anti-CFTR antibody immunohistochemical staining. The average level of expression by tumor is summarized in the table below. The variability row represents patient to patient variability in IHC staining.

Sample Type breast cancer carcinoid cervical cancer colorectal cancer endometrial cancer glioma head and neck cancer liver cancer lung cancer lymphoma melanoma ovarian cancer pancreatic cancer prostate cancer renal cancer skin cancer stomach cancer testicular cancer thyroid cancer urothelial cancer
Signal Intensity - - - - - - - - - - - - - - - - - - - -
CFTR Variability + ++ + + + + + + + + + + ++ + + + + + + +

Limitations and Warranty

enQuire Bio's CFTR Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

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