Formalin-fixed, paraffin-embedded human Parathyroid stained with Chromogranin A Recombinant Rabbit Monoclonal Antibody (CHGA/1773R)
Formalin-fixed, paraffin-embedded human Parathyroid stained with Chromogranin A Recombinant Rabbit Monoclonal Antibody (CHGA/1773R)

Anti-Chromogranin A Antibody Clone CHGA/1773R

$ 199.00$ 549.00
Please Select Product Options Below To View The Catalog Number.

SKU: 1113-RBM13
Species: Human and Rat (-)
Tested Applications: Immunohistochemistry (IHC)
Available Conjugates: Unconjugated
Isotype: Rabbit IgG kappa
Mass Spec Validated?: Not MS Validated

Product NumberDescriptionPrice
1113-RBM13-P0 Size: 20 ug, Tag: Unconjugated $ 199.00
1113-RBM13-P1 Size: 100 ug, Tag: Unconjugated $ 429.00
1113-RBM13-P2 Size: 200 ug, Tag: Unconjugated $ 549.00
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SKU: 1113-RBM13-P0
Chromogranin A General Information
Alternate Names
TIMP metallopeptidase inhibitor 1, TIMP1, Tissue Inhibitor of Metalloproteinase 1
Molecular Weight
Chromosomal Location
Curated Database and Bioinformatic Data
Gene SymbolCHGA
Entrez Gene ID1113
Ensemble Gene IDENSG00000276781, ENSG00000100604
RefSeq Protein Accession(s)NP_001288619, XP_011534672, NP_001266
RefSeq mRNA Accession(s)XM_011536370, NM_001301690, NM_001275
RefSeq Genomic Accession(s)NC_000014, NG_187601, NC_018925
UniProt ID(s)Q86T07, P10645, G5E968
UniGene ID(s)Q86T07, P10645, G5E968
HGNC ID(s)1929
Cosmic ID(s)CHGA
KEGG Gene ID(s)hsa:1113
PharmGKB ID(s)PA26461
General Description of Chromogranin A.
Chromogranin A is present in neuroendocrine cells throughout the body, including the neuroendocrine cells of the large and small intestine, adrenal medulla and pancreatic islets. It is an excellent marker for carcinoid tumors, pheochromocytomas, paragangliomas, and other neuroendocrine tumors. Co-expression of chromogranin A and neuron specific enolase (NSE) is common in neuroendocrine neoplasms. Reportedly, co-expression of certain keratins and chromogranin indicates neuroendocrine lineage. The presence of strong anti-chromogranin staining and absence of anti-keratin staining should raise the possibility of paraganglioma. The co-expression of chromogranin and NSE is typical of neuroendocrine neoplasms. Most pituitary adenomas and prolactinomas readily express chromogranin.

Human and Rat (-) Anti-Chromogranin A Antibody Product Attributes

Species: Human and Rat (-)
Tested Applications: Immunohistochemistry (IHC).
Clonality: Recombinant Monoclonal
Anti-Chromogranin A Antibody Clone: CHGA/1773R
Clone CHGA/1773R Host and Isotype: Rabbit IgG kappa
Anti-Human and Rat (-) Chromogranin A Positive Control Sample: PC12 cells. Adrenal gland, bowel, parathyroid, pancreas, or pheochromocytoma.
Cellular Localization of Antibody Finely granular cytoplasmic
Buffer and Stabilizer: 10mM PBS with or without 0.05% BSA & 0.05% azide.
Antibody Concentration: 200ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Recombinant human full-length Chromogranin A protein
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.

Chromogranin A Previously Observed Antibody Staining Patterns

Observed Subcellular, Organelle Specific Staining Data:

Anti-CHGA antibody staining is expected to be primarily localized to the vesicles.

Observed Antibody Staining Data By Tissue Type:

Variations in Chromogranin A antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in glandular cells in the parathyroid gland and islets of Langerhans in pancreas. More moderate antibody staining intensity was present in glandular cells in the parathyroid gland and islets of Langerhans in pancreas. Low, but measureable presence of Chromogranin A could be seen inneuronal cells in the caudate nucleus, cerebral cortex and hippocampus, respiratory epithelial cells in the bronchus and neuronal cells in the caudate nucleus and cerebral cortex and hippocampus. We were unable to detect Chromogranin A in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.

Observed Antibody Staining Data By Tissue Disease Status:

Tissues from cancer patients, for instance, have their own distinct pattern of Chromogranin A expression as measured by anti-Chromogranin A antibody immunohistochemical staining. The average level of expression by tumor is summarized in the table below. The variability row represents patient to patient variability in IHC staining.

Sample Type breast cancer carcinoid cervical cancer colorectal cancer endometrial cancer glioma head and neck cancer liver cancer lung cancer lymphoma melanoma ovarian cancer pancreatic cancer prostate cancer renal cancer skin cancer stomach cancer testicular cancer thyroid cancer urothelial cancer
Signal Intensity - +++ - - - - - - - - - - - - - - - - - -
CHGA Variability + + + + ++ + ++ + + + + + + + + ++ ++ + + +

Limitations and Warranty

enQuire Bio's Chromogranin A Recombinant Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

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Anti-Chromogranin A Antibody Clone CHGA/1773R