Formalin-fixed, paraffin-embedded human Tonsil stained with Connexin 32 Monoclonal Antibody (GJB1/1753)
Formalin-fixed, paraffin-embedded human Tonsil stained with Connexin 32 Monoclonal Antibody (GJB1/1753)

Anti-Connexin 32 Antibody Clone GJB1/1753

$ 118.00$ 418.00
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SKU: 2705-MSM3
Species: Human, Mouse, and Rat
Tested Applications: Immunohistochemistry (IHC)
Available Conjugates: Unconjugated
Isotype: Mouse IgG
Mass Spec Validated?: Not MS Validated

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Datasheets and Documentation
Product Datasheet
SKU: 2705-MSM3-P0
Connexin 32 General Information
Alternate Names
Gap junction beta-1 protein, GJB1, connexin 32, Cx32
Molecular Weight
27-32kDa
Chromosomal Location
Xq13.1
Curated Database and Bioinformatic Data
Gene SymbolGJB1
Entrez Gene ID2705
Ensemble Gene IDENSG00000169562
RefSeq Protein Accession(s)NP_000157, XP_011529209, NP_001091111, XP_016884897
RefSeq mRNA Accession(s)XM_011530907, XM_017029408, NM_001097642 NM_000166
RefSeq Genomic Accession(s)NC_000023, NG_008357, NC_018934
UniProt ID(s)P08034
UniGene ID(s)P08034
HGNC ID(s)4283
Cosmic ID(s)GJB1
KEGG Gene ID(s)hsa:2705
PharmGKB ID(s)PA28694
General Description of Connexin 32.
This Ab recognizes a protein of 27-32kDa, identified as Connexin 32. The connexin family of proteins forms hexameric complexes called connexons that facilitate movement of low molecular weight proteins between cells via gap junctions. Connexin proteins share a common topology of four transmembrane ?-helical domains, two extracellular loops, a cytoplasmic loop and cytoplasmic N- and C-termini. Many of the key functional differences arise from specific amino-acid substitutions in the most highly conserved domains, the transmembrane and extracellular regions. Each of the approximately 20-connexin isoforms produces channels with distinct permeability and electrical and chemical sensitivities ;therefore, one connexin usually cannot fully substitute for another.

Human, Mouse, and Rat Anti-Connexin 32 Antibody Product Attributes

Species: Human, Mouse, and Rat
Tested Applications: Immunohistochemistry (IHC).
Clonality: Monoclonal
Anti-Connexin 32 Antibody Clone: GJB1/1753
Clone GJB1/1753 Host and Isotype: Mouse IgG
Anti-Human, Mouse, and Rat Connexin 32 Positive Control Sample: MCF-7 Cells. Liver, Kidney, Stomach or Tonsil
Cellular Localization of Antibody Cytoplasmic and Cell Surface
Buffer and Stabilizer: 10mM PBS with 0.05% BSA and 0.05% Azide
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Recombinant human GJB1 protein
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.

Connexin 32 Previously Observed Antibody Staining Patterns

Observed Antibody Staining Data By Tissue Disease Status:

Tissues from cancer patients, for instance, have their own distinct pattern of Connexin 32 expression as measured by anti-Connexin 32 antibody immunohistochemical staining. The average level of expression by tumor is summarized in the table below. The variability row represents patient to patient variability in IHC staining.

Sample Type breast cancer carcinoid cervical cancer colorectal cancer endometrial cancer glioma head and neck cancer liver cancer lung cancer lymphoma melanoma ovarian cancer pancreatic cancer prostate cancer renal cancer skin cancer stomach cancer testicular cancer thyroid cancer urothelial cancer
Signal Intensity +++ ++ ++ +++ +++ + + ++ ++ + ++ +++ +++ +++ + + +++ ++ + ++
GJB1 Variability ++ ++ ++ + ++ ++ ++ ++ ++ ++ ++ ++ ++ + ++ + ++ ++ ++ ++

Limitations and Warranty

enQuire Bio's Connexin 32 Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

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Anti-Connexin 32 Antibody Clone GJB1/1753

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