Formalin-fixed, paraffin-embedded human Bladder Carcinoma stained with Cytokeratin 1 Monoclonal Antibody (LH2).
Formalin-fixed, paraffin-embedded human Bladder Carcinoma stained with Cytokeratin 1 Monoclonal Antibody (LH2).

Anti-Cytokeratin 10 Antibody Clone LH2

$ 298.00
Please Select Product Options Below To View The Catalog Number.

SKU: 3858-MSM1
Species: Human and Mouse
Tested Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry (IHC)
Available Conjugates: Unconjugated
Isotype: Mouse IgG1 kappa
Mass Spec Validated?: Not MS Validated

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Datasheets and Documentation
Product Datasheet
SKU: 3858-MSM1-P1
Cytokeratin 10 General Information
Alternate Names
Keratin, type I cytoskeletal 10, cytokeratin-10, CK-10, keratin-10, K10, KRT10
Molecular Weight
56.5kDa
Chromosomal Location
17q21.2
Curated Database and Bioinformatic Data
Gene SymbolKRT10
Entrez Gene ID3858
Ensemble Gene IDENSG00000186395
RefSeq Protein Accession(s)XP_005257400, NP_000412
RefSeq mRNA Accession(s)NM_000421, XM_005257343
RefSeq Genomic Accession(s)NC_018928, NG_033147, NG_008405, NC_000017
UniProt ID(s)P13645
UniGene ID(s)P13645
HGNC ID(s)6413
Cosmic ID(s)KRT10
KEGG Gene ID(s)hsa:3858
PharmGKB ID(s)PA30200
General Description of Cytokeratin 10.
This MAb recognizes a protein of 56.5kDa, identified as cytokeratin 10 (CK10). CK10 is expressed in all suprabasal layers of the epidermis. In the epidermis, expression of CK10 strictly parallels the extent of differentiation; it is absent in the basal layer, appears in the first suprabasal layers, increases in concentration towards the granular layer. However, CK10 is rarely detected in early stages of vulvar squamous carcinomas (tumors less than 2 cm, clinical stage I) regardless of the tumor grade. In larger, more advanced tumors (greater than 2 cm, clinical stages II, III), CK10 is detected very frequently. Expression of CK10 is related to maturation of malignant keratinocytes, being preferentially detected in more-differentiated parts.

Human and Mouse Anti-Cytokeratin 10 Antibody Product Attributes

Species: Human and Mouse
Tested Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry (IHC).
Application Notes: Flow Cytometry (0.5-1ug of antibody/million cells in 0.1ml), Immunofluorescence (0.5-1ug of antibody/ml), Immunohistochemistry (IHC) (Formalin-fixed) (0.1-0.2ug of antibody/ml for 30 min at RT)
Clonality: Monoclonal
Anti-Cytokeratin 10 Antibody Clone: LH2
Clone LH2 Host and Isotype: Mouse IgG1 kappa
Anti-Human and Mouse Cytokeratin 10 Positive Control Sample: A431, HeLa, MCF7 cells. Esophagus or tonsil.
Cellular Localization of Antibody Cytoplasmic
Buffer and Stabilizer: 10mM PBS with 0.05% BSA & 0.05% azide.
Antibody Concentration: 200ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Skin extract of a human Psoriasis patient
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.

Cytokeratin 10 Previously Observed Antibody Staining Patterns

Observed Antibody Staining Data By Tissue Type:

Variations in Cytokeratin 10 antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in epidermal cells in the skin and keratinocytes in skin. More moderate antibody staining intensity was present in epidermal cells in the skin and keratinocytes in skin. Low, but measureable presence of Cytokeratin 10 could be seen in. We were unable to detect Cytokeratin 10 in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.

Limitations and Warranty

enQuire Bio's Cytokeratin 10 Anti-Human, Mouse Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

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