Formalin-fixed, paraffin-embedded human Lung Carcinoma stained with Cytokeratin 8/18 Monoclonal Antibody (SPM141).
Formalin-fixed, paraffin-embedded human Lung Carcinoma stained with Cytokeratin 8/18 Monoclonal Antibody (SPM141).

Anti-Cytokeratin 8/18 Antibody Clone SPM141

$ 298.00
Please Select Product Options Below To View The Catalog Number.

SKU: MSM6X-691
Species: Human
Tested Applications: Flow Cytometry, Immunofluorescence, Western Blot, Immunohistochemistry (IHC)
Available Conjugates: Unconjugated
Isotype: Mouse IgG1 kappa
Mass Spec Validated?: Not MS Validated

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Datasheets and Documentation
Product Datasheet
SKU: MSM6X-691-P1
Cytokeratin 8/18 General Information
Alternate Names
CARD2, CK8, CYK8, CYKER, Cytokeratin Endo A, DreK8, EndoA, K2C8, K8, Keratin 8, Krt 2.8, KRT8, Type-II Keratin Kb8. Cell Proliferation-inducing Gene 46 Protein, CK18, CYK18 Cytokeratin Endo B, K18, Keratin-18, Kerd, KRT18, anti-CARD2 antibody, anti-CK8 antibody, anti-CYK8 antibody, anti-CYKER antibody, anti-Cytokeratin Endo A antibody, anti-DreK8 antibody, anti-EndoA antibody, anti-K2C8 antibody, anti-K8 antibody, anti-Keratin 8 antibody, anti-Krt 2.8 antibody, anti-KRT8 antibody, anti-Type-II Keratin Kb8. Cell Proliferation-inducing Gene 46 Protein antibody, anti-CK18 antibody, anti-CYK18 Cytokeratin Endo B antibody, anti-K18 antibody, anti-Keratin-18 antibody, anti-Kerd antibody, anti-KRT18 antibody
Molecular Weight
52.5kDa (CK8); 45kDa (CK18)
Chromosomal Location
17q21.2 (CK8); 12q13.13 (CK18)
Curated Database and Bioinformatic Data
Gene SymbolKRT8 & KRT18
Entrez Gene ID3856, 3875
Ensemble Gene IDENSG00000170421, ENSG00000111057
RefSeq Protein Accession(s)NP_001243211, NP_002264, NP_001243222, NP_954657, NP_000215
RefSeq mRNA Accession(s)NR_045962 NM_001256282, NM_001256293, NM_002273, NM_199187, NM_000224
RefSeq Genomic Accession(s)NC_000012, NC_018923, NG_008402, NC_000012, NG_008351, NG_008402, NC_018923
UniProt ID(s)P05787, Q7L4M3, P05783, A0A024RAY2
UniGene ID(s)P05787, Q7L4M3, P05783, A0A024RAY2
HGNC ID(s)6446, 6430
Cosmic ID(s)KRT8, KRT18
KEGG Gene ID(s)hsa:3856, hsa:3875
PharmGKB ID(s)PA30234, PA30217
General Description of Cytokeratin 8/18.
Cytokeratin 8 (CK8) belongs to the type II (or B or basic) subfamily of high molecular weight cytokeratins, exists in combination with cytokeratin 18 (CK18). This MAb cocktail recognizes all simple epithelia including glandular epithelium, for example thyroid, female breast, gastrointestinal tract, respiratory tract,, urogenital tract including transitional epithelium. All adenocarcinomas, most squamous carcinomas are positive but keratinizing squamous carcinomas are usually negative. This antibody is useful in demonstrating the presence of Paget cells; there is very little keratin 18 in the normal epidermis so only Paget cells are stained.

Human Anti-Cytokeratin 8/18 Antibody Product Attributes

Species: Human
Tested Applications: Flow Cytometry, Immunofluorescence, Western Blot, Immunohistochemistry (IHC).
Application Notes: Flow Cytometry (0.5-1ug of antibody/million cells in 0.1ml), Immunofluorescence (1-2ug of antibody/ml), Western Blot (0.5-1.0ug of antibody/ml), Immunohistochemistry (IHC) (Formalin-fixed) (0.5-1.0ug of antibody/ml for 30 min at RT)
Clonality: Monoclonal
Anti-Cytokeratin 8/18 Antibody Clone: SPM141
Clone SPM141 Host and Isotype: Mouse IgG1 kappa
Anti-Human Cytokeratin 8/18 Positive Control Sample: MCF-7 or A431 cells. Skin, Colon, lung or breast carcinoma
Cellular Localization of Antibody Cytoplasmic
Buffer and Stabilizer: 10mM PBS with 0.05% BSA & 0.05% azide.
Antibody Concentration: 200ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Keratin preparation from human breast carcinoma MCF-7 cells
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.

Cytokeratin 8/18 Previously Observed Antibody Staining Patterns

Limitations and Warranty

enQuire Bio's Cytokeratin 8/18 Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

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Anti-Cytokeratin 8/18 Antibody Clone SPM141