Human Anti-Cytokeratin, Acidic Antibody Product Attributes
Tested Applications: Immunohistochemistry (IHC).
Clonality: Recombinant Monoclonal
Anti-Cytokeratin, Acidic Antibody Clone: KRTL/1577R
Clone KRTL/1577R Host and Isotype: Rabbit IgG kappa
Anti-Human Cytokeratin, Acidic Positive Control Sample: Skin, Squamous cell carcinoma (SCC)
Cellular Localization of Antibody
Buffer and Stabilizer: 10mM PBS with or without 0.05% BSA & 0.05% azide.
Antibody Concentration: 200ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Recombinant human KRT77 protein fragment
Storage Conditions: Store at 2 to 8Â° C (refrigerate). Stable for 24 months when properly stored.
Cytokeratin, Acidic Previously Observed Antibody Staining Patterns
Observed Subcellular, Organelle Specific Staining Data:Anti-KRT77 antibody staining is expected to be primarily localized to the nuclear membrane and plasma membrane.
Observed Antibody Staining Data By Tissue Type:Variations in Cytokeratin, Acidic antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in keratinocytes in skin and squamous epithelial cells in the oral mucosa. More moderate antibody staining intensity was present in keratinocytes in skin and squamous epithelial cells in the oral mucosa. Low, but measureable presence of Cytokeratin, Acidic could be seen inepidermal cells in the skin, Langerhans in skin, squamous epithelial cells in the cervix and uterine and esophagus. We were unable to detect Cytokeratin, Acidic in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.
Observed Antibody Staining Data By Tissue Disease Status:Tissues from cancer patients, for instance, have their own distinct pattern of Cytokeratin, Acidic expression as measured by anti-Cytokeratin, Acidic antibody immunohistochemical staining. The average level of expression by tumor is summarized in the table below. The variability row represents patient to patient variability in IHC staining.
|Sample Type||breast cancer||carcinoid||cervical cancer||colorectal cancer||endometrial cancer||glioma||head and neck cancer||liver cancer||lung cancer||lymphoma||melanoma||ovarian cancer||pancreatic cancer||prostate cancer||renal cancer||skin cancer||stomach cancer||testicular cancer||thyroid cancer||urothelial cancer|
Limitations and Warranty
enQuire Bio's Cytokeratin, Acidic Recombinant Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.