Formalin-fixed, paraffin-embedded human Leiomyosarcoma stained with Desmin Monoclonal Antibody (D33)

Anti-Desmin Antibody Clone D33

$ 118.00$ 418.00
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SKU: 1674-MSM2
Species: Human
Tested Applications: Immunohistochemistry (IHC)
Available Conjugates: Unconjugated
Isotype: Mouse IgG1 kappa
Mass Spec Validated?: Not MS Validated

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Datasheets and Documentation
Product Datasheet
SKU: 1674-MSM2-CS0
Desmin General Information
Alternate Names
Desmin, DES
Molecular Weight
52kDa
Chromosomal Location
2q35
Curated Database and Bioinformatic Data
Gene SymbolDES
Entrez Gene ID1674
Ensemble Gene IDENSG00000175084
RefSeq Protein Accession(s)NP_001918
RefSeq mRNA Accession(s)NM_001927
RefSeq Genomic Accession(s)NC_000002, NC_018913, NG_008043
UniProt ID(s)P17661, Q53SB5
UniGene ID(s)P17661, Q53SB5
HGNC ID(s)2770
Cosmic ID(s)DES
KEGG Gene ID(s)hsa:1674
PharmGKB ID(s)PA27253
General Description of Desmin.
Cytoskeletal intermediate filaments (IFs) constitute a diverse group of proteins that are expressed in a highly tissue-specific manner. IFs are constructed from two-chain ?-helical coiled-coil molecules arranged on an imperfect helical lattice, and have been widely used as markers for distinguishing individual cell types within a tissue and identifying the origins of metastatic tumors. Vimentin is an IF general marker of cells originating in the mesenchyme. Vimentin and Desmin, a related class III IF, are both expressed during skeletal muscle development. Desmin, a 469 amino acid protein found near the Z line in sarcomeres, is expressed more frequently in adult differentiated state tissues. Anti-desmin detects cells of normal smooth, skeletal, and cardiac muscles. Antibody reacts with leiomyomas, leiomyosarcoma, rhabdomyomas, rhabdomyosarcoma, and perivascular cells of glomus tumors of the skin.

Human Anti-Desmin Antibody Product Attributes

Species: Human
Tested Applications: Immunohistochemistry (IHC).
Clonality: Monoclonal
Anti-Desmin Antibody Clone: D33
Clone D33 Host and Isotype: Mouse IgG1 kappa
Anti-Human Desmin Positive Control Sample: SJRH30 Cells. Uterus or Leiomyosarcoma
Cellular Localization of Antibody Cytoplasmic
Buffer and Stabilizer: 10mM PBS
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Proteins from human Leiomyoma
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.

Desmin Previously Observed Antibody Staining Patterns

Observed Subcellular, Organelle Specific Staining Data:

Anti-DES antibody staining is expected to be primarily localized to the intermediate filaments.

Observed Antibody Staining Data By Tissue Type:

Variations in Desmin antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in myocytes in heart muscle and skeletal muscle and smooth muscle cells in the smooth muscle. More moderate antibody staining intensity was present in myocytes in heart muscle and skeletal muscle and smooth muscle cells in the smooth muscle. Low, but measureable presence of Desmin could be seen in. We were unable to detect Desmin in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.

Limitations and Warranty

enQuire Bio's Desmin Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

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Anti-Desmin Antibody Clone D33