Formalin-fixed, paraffin-embedded Human Skin stained with Desmoglein-3 Monoclonal Antibody (DSG3/1535).
Formalin-fixed, paraffin-embedded Human Skin stained with Desmoglein-3 Monoclonal Antibody (DSG3/1535).

Anti-Desmoglein-3 Antibody Clone DSG3/1535

$ 118.00$ 418.00
Please Select Product Options Below To View The Catalog Number.

SKU: 1830-MSM5
Species: Human
Tested Applications: Immunohistochemistry (IHC)
Available Conjugates: Unconjugated
Isotype: Mouse IgG1 kappa
Mass Spec Validated?: Not MS Validated

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Datasheets and Documentation
Product Datasheet
SKU: 1830-MSM5-P0
Desmoglein-3 General Information
Alternate Names
Desmoglein-3, DSG3
Molecular Weight
130kDa
Chromosomal Location
18q12.1
Curated Database and Bioinformatic Data
Gene SymbolDSG3
Entrez Gene ID1830
Ensemble Gene IDENSG00000134757
RefSeq Protein Accession(s)XP_011524152, NP_001935
RefSeq mRNA Accession(s)XM_011525850, NM_001944
RefSeq Genomic Accession(s)NC_000018, NC_018929
UniProt ID(s)P32926
UniGene ID(s)P32926
HGNC ID(s)3050
Cosmic ID(s)DSG3
KEGG Gene ID(s)hsa:1830
PharmGKB ID(s)PA27503
General Description of Desmoglein-3.
Recognizes a protein of 130kDa, identified as Desmoglein-3 (DSG3). This MAb is highly specific to Desmoglein-3 and does not cross-react with other members of the Desmoglein-family. DSG3 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Research has shown that DSG3 has a very high sensitivity (>80%) and specificity (100%) in recognizing squamous cell carcinoma (SqCC). Therefore, DSG3 is considered a very important marker for lung SqCC and can be a useful ancillary marker to separate SqCC from other subtypes of lung cancer. Moreover, studies have shown that DSG3 expression in lung SqCC may indicate a poor prognosis.

Human Anti-Desmoglein-3 Antibody Product Attributes

Species: Human
Tested Applications: Immunohistochemistry (IHC).
Clonality: Monoclonal
Anti-Desmoglein-3 Antibody Clone: DSG3/1535
Clone DSG3/1535 Host and Isotype: Mouse IgG1 kappa
Anti-Human Desmoglein-3 Positive Control Sample: A431 cells. Skin or Lung squamous cell carcinoma.
Cellular Localization of Antibody Cell surface
Buffer and Stabilizer: 10mM PBS with 0.05% BSA and 0.05% Azide
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Recombinant human DSG3 extracellular protein fragment
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.

Desmoglein-3 Previously Observed Antibody Staining Patterns

Observed Antibody Staining Data By Tissue Type:

Variations in Desmoglein-3 antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. Low, but measureable presence of Desmoglein-3 could be seen insquamous epithelial cells in the cervix, uterine, oral mucosa. We were unable to detect Desmoglein-3 in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.

Limitations and Warranty

enQuire Bio's Desmoglein-3 Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

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