Formalin-fixed, paraffin-embedded human GIST stained with Canine1 Monoclonal Antibody (Canine1.1).
Formalin-fixed, paraffin-embedded human GIST stained with Canine1 Monoclonal Antibody (Canine1.1).

Anti-DOG-1 / TMEM16A / ANO1 Antibody Clone DOG-1.1

$ 329.00
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SKU: 55107-MSM2
Species: Human
Tested Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry (IHC)
Available Conjugates: Unconjugated
Isotype: Mouse IgG1 kappa
Mass Spec Validated?: Not MS Validated

Product NumberDescriptionPrice
55107-MSM2-P1 Size: 100 ug, Tag: Unconjugated
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In Stock.
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SKU: 55107-MSM2-P1
DOG-1 / TMEM16A / ANO1 General Information
Alternate Names
Transmembrane member 16A, TMEM16A, Canine1, Anoctamin-1, ANO1
Molecular Weight
~114kDa
Chromosomal Location
11q13.3
Curated Database and Bioinformatic Data
Gene SymbolTMEM16A
Entrez Gene ID55107
Ensemble Gene IDENSG00000131620
RefSeq Protein Accession(s)XP_006718665, XP_006718668, XP_011543433, XP_011543425, XP_011543426, XP_011543431, XP_011543423, XP_016873445, XP_016873446, XP_006718667, XP_011543430, XP_011543427, XP_011543429, NP_060513, XP_011543428
RefSeq mRNA Accession(s)XM_011545121, XM_011545128, NR_030691, XM_011545124, XM_011545131, XM_006718602, XM_011545123, XM_011545126, XM_011545127, XM_006718604, XM_011545129, XM_017017957, NM_018043, XM_006718605, XM_011545125, XM_017017956
RefSeq Genomic Accession(s)NC_018922, NC_000011
UniProt ID(s)Q9NW72, Q5XXA6
UniGene ID(s)Q9NW72, Q5XXA6
HGNC ID(s)21625
Cosmic ID(s)ANO1
KEGG Gene ID(s)hsa:55107
PharmGKB ID(s)PA164715378
General Description of DOG-1 / TMEM16A / ANO1.
Expression of DOG-1 protein is elevated in the gastrointestinal stromal tumors (GISTs), c-kit signaling-driven mesenchymal tumors of the GI tract. DOG-1 is rarely expressed in other soft tissue tumors, which, due to appearance, may be difficult to diagnose. Immunoreactivity for DOG-1 has been reported in 97.8 percent of scorable GISTs, including all c-kit negative GISTs. Overexpression of DOG-1 has been suggested to aid in the identification of GISTs, including Platelet-Derived Growth Factor Receptor Alpha mutants that fail to express c-kit antigen. The overall sensitivity of Canine1, c-kit in GISTs is nearly identical: 94.4% vs. 94.7%.

Human Anti-DOG-1 / TMEM16A / ANO1 Antibody Product Attributes

Species: Human
Tested Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry (IHC).
Application Notes: Flow Cytometry (0.5-1ug of antibody/million cells in 0.1ml), Immunofluorescence (0.5-1ug of antibody/ml), Immunohistochemistry (IHC) (Formalin-fixed) (0.25-0.5ug of antibody/ml for 30 minutes at RT)
Clonality: Monoclonal
Anti-DOG-1 / TMEM16A / ANO1 Antibody Clone: DOG-1.1
Clone DOG-1.1 Host and Isotype: Mouse IgG1 kappa
Anti-Human DOG-1 / TMEM16A / ANO1 Positive Control Sample: Gastrointestinal Stromal Tumor (GIST) or testicular germ cell tumor. Melanocytes in the basal layer of the epidermis, mast cells in the dermis of normal skin.
Cellular Localization of Antibody Cell Surface, Cytoplasm
Buffer and Stabilizer: 10mM PBS with 0.05% BSA & 0.05% azide.
Antibody Concentration: 200ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: A synthetic peptide from human DOG-1 protein (MSDFVDWVIPDIPKDISQQIHKEKVLMVELFMREEQDKQQL-LETCMEKERQKDEPPCNHHNTKACPDSLGSPAPSHAYHGGVL), conjugated to a carrier protein.
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.

DOG-1 / TMEM16A / ANO1 Previously Observed Antibody Staining Patterns

Limitations and Warranty

enQuire Bio's DOG-1 / TMEM16A / ANO1 Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

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Anti-DOG-1 / TMEM16A / ANO1 Antibody Clone DOG-1.1

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