Formalin-fixed, paraffin-embedded human GIST stained with DOG-1 Monoclonal Antibody (DG1/1484).

Anti-DOG-1 / TMEM16A Antibody Clone DG1/1484

$ 118.00$ 418.00
Please Select Product Options Below To View The Catalog Number.

SKU: 55107-MSM4
Species: Human
Tested Applications: Immunohistochemistry (IHC)
Available Conjugates: Unconjugated
Isotype: Mouse IgG2b kappa
Mass Spec Validated?: Not MS Validated

Product NumberDescriptionPrice
55107-MSM4-P0 Size: 20 ug, Tag: Unconjugated $ 118.00
55107-MSM4-P1 Size: 100 ug, Tag: Unconjugated $ 298.00
55107-MSM4-P2 Size: 200 ug, Tag: Unconjugated $ 418.00
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In Stock.
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SKU: 55107-MSM4-P0
DOG-1 / TMEM16A General Information
Alternate Names
Transmembrane member 16A, TMEM16A, Canine1, Anoctamin-1, ANO1
Molecular Weight
114kDa
Chromosomal Location
11q13.3
Curated Database and Bioinformatic Data
Gene SymbolTMEM16A
Entrez Gene ID55107
Ensemble Gene IDENSG00000131620
RefSeq Protein Accession(s)XP_006718665, XP_006718668, XP_011543433, XP_011543425, XP_011543426, XP_011543431, XP_011543423, XP_016873445, XP_016873446, XP_006718667, XP_011543430, XP_011543427, XP_011543429, NP_060513, XP_011543428
RefSeq mRNA Accession(s)XM_011545121, XM_011545128, NR_030691, XM_011545124, XM_011545131, XM_006718602, XM_011545123, XM_011545126, XM_011545127, XM_006718604, XM_011545129, XM_017017957, NM_018043, XM_006718605, XM_011545125, XM_017017956
RefSeq Genomic Accession(s)NC_018922, NC_000011
UniProt ID(s)Q9NW72, Q5XXA6
UniGene ID(s)Q9NW72, Q5XXA6
HGNC ID(s)21625
Cosmic ID(s)ANO1
KEGG Gene ID(s)hsa:55107
PharmGKB ID(s)PA164715378
General Description of DOG-1 / TMEM16A.
Expression of DOG-1 protein is elevated in the gastrointestinal stromal tumors (GIST s), c-kit signaling-driven mesenchymal tumors of the GI tract. DOG-1 is rarely expressed in other soft tissue tumors, which, due to appearance, may be difficult to diagnose. Immunoreactivity for DOG-1 has been reported in 97.8 percent of scorable GIST s, including all c-kit negative GIST s. Overexpression of DOG-1 has been suggested to aid in the identification of GISTs, including Platelet-Derived Growth Factor Receptor Alpha mutants that fail to express c-kit antigen. The overall sensitivity of Canine1 and c-kit in GIST s is nearly identical: 94.4% vs. 94.7%.

Human Anti-DOG-1 / TMEM16A Antibody Product Attributes

Species: Human
Tested Applications: Immunohistochemistry (IHC).
Clonality: Monoclonal
Anti-DOG-1 / TMEM16A Antibody Clone: DG1/1484
Clone DG1/1484 Host and Isotype: Mouse IgG2b kappa
Anti-Human DOG-1 / TMEM16A Positive Control Sample: Gastrointestinal Stromal Tumor (GIST) or testicular germ cell tumor. Melanocytes in the basal layer of the epidermis and mast cells in the dermis of normal skin.
Cellular Localization of Antibody Cell Surface and Cytoplasm
Buffer and Stabilizer: 10mM PBS with 0.05% BSA and 0.05% Azide
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Recombinant human DOG-1 protein fragment (aa 2-101)
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.

DOG-1 / TMEM16A Previously Observed Antibody Staining Patterns

Limitations and Warranty

enQuire Bio's DOG-1 / TMEM16A Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

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Anti-DOG-1 / TMEM16A Antibody Clone DG1/1484