Formalin-fixed, paraffin-embedded human GIST stained with Canine1 Monoclonal Antibody (DG1/447).
Formalin-fixed, paraffin-embedded human GIST stained with Canine1 Monoclonal Antibody (DG1/447).

Anti-DOG-1 / TMEM16A Antibody Clone DG1/447

$ 298.00
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SKU: 55107-MSM1
Species: Human
Tested Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry (IHC)
Available Conjugates: Unconjugated
Isotype: Mouse IgG1 kappa
Mass Spec Validated?: Not MS Validated

Product NumberDescriptionPrice
55107-MSM1-P1 Size: 100 ug, Tag: Unconjugated
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SKU: 55107-MSM1-P1
DOG-1 / TMEM16A General Information
Alternate Names
Transmembrane member 16A, TMEM16A, Canine1, Anoctamin-1, ANO1
Molecular Weight
~114kDa
Chromosomal Location
11q13.3
Curated Database and Bioinformatic Data
Gene Symbol TMEM16A
Entrez Gene ID 55107
Ensemble Gene ID ENSG00000131620
RefSeq Protein Accession(s) XP_006718665, XP_006718668, XP_011543433, XP_011543425, XP_011543426, XP_011543431, XP_011543423, XP_016873445, XP_016873446, XP_006718667, XP_011543430, XP_011543427, XP_011543429, NP_060513, XP_011543428
RefSeq mRNA Accession(s) XM_011545121, XM_011545128, NR_030691, XM_011545124, XM_011545131, XM_006718602, XM_011545123, XM_011545126, XM_011545127, XM_006718604, XM_011545129, XM_017017957, NM_018043, XM_006718605, XM_011545125, XM_017017956
RefSeq Genomic Accession(s) NC_018922, NC_000011
UniProt ID(s) Q9NW72, Q5XXA6
UniGene ID(s) Q9NW72, Q5XXA6
HGNC ID(s) 21625
Cosmic ID(s) ANO1
KEGG Gene ID(s) hsa:55107
PharmGKB ID(s) PA164715378
General Description of DOG-1 / TMEM16A.
Expression of DOG-1 protein is elevated in the gastrointestinal stromal tumors (GISTs), c-kit signaling-driven mesenchymal tumors of the GI tract. DOG-1 is rarely expressed in other soft tissue tumors, which, due to appearance, may be difficult to diagnose. Immunoreactivity for DOG-1 has been reported in 97.8 percent of scorable GISTs, including all c-kit negative GISTs. Overexpression of DOG-1 has been suggested to aid in the identification of GISTs, including Platelet-Derived Growth Factor Receptor Alpha mutants that fail to express c-kit antigen. The overall sensitivity of Canine1, c-kit in GISTs is nearly identical: 94.4% vs. 94.7%.

Human Anti-DOG-1 / TMEM16A Antibody Product Attributes

Species: Human
Tested Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry (IHC).
Application Notes: Flow Cytometry (0.5-1ug of antibody/million cells), Immunofluorescence (0.5-1ug of antibody/ml), Immunohistochemistry (IHC) (Formalin-fixed) (0.25-0.5ug of antibody/ml for 30 minutes at RT)
Clonality: Monoclonal
Anti-DOG-1 / TMEM16A Antibody Clone: DG1/447
Clone DG1/447 Host and Isotype: Mouse IgG1 kappa
Anti-Human DOG-1 / TMEM16A Positive Control Sample: Gastrointestinal Stromal Tumor (GIST) or testicular germ cell tumor. Melanocytes in the basal layer of the epidermis, mast cells in the dermis of normal skin.
Cellular Localization of Antibody <DG1/447 Staining: Cell Surface, Cytoplasm
Buffer and Stabilizer: 10mM PBS with 0.05% BSA & 0.05% azide.
Antibody Concentration: 200ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Recombinant human DOG-1 protein
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.

DOG-1 / TMEM16A Previously Observed Antibody Staining Patterns

Limitations and Warranty

enQuire Bio's DOG-1 / TMEM16A Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

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Anti-DOG-1 / TMEM16A Antibody Clone DG1/447

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