Western Blot of HeLa and A431 Cell Lysates with endoglin / CD15 Monoclonal Antibody (ENG/1327).
Western Blot of HeLa and A431 Cell Lysates with endoglin / CD15 Monoclonal Antibody (ENG/1327).

Anti-endoglin / CD105 Antibody Clone ENG/1327

$ 118.00$ 418.00
Please Select Product Options Below To View The Catalog Number.

SKU: 2022-MSM2
Species: Human
Tested Applications: Western Blot
Available Conjugates: Unconjugated
Isotype: Mouse IgG1
Mass Spec Validated?: Not MS Validated

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Datasheets and Documentation
Product Datasheet
SKU: 2022-MSM2-P0
endoglin / CD105 General Information
Alternate Names
endoglin, ENG, CD105, Cluster of Differentiation 105, S-endoglin
Molecular Weight
84kDa
Chromosomal Location
9q34.11
Curated Database and Bioinformatic Data
Gene SymbolENG
Entrez Gene ID2022
Ensemble Gene IDENSG00000106991
RefSeq Protein Accession(s)NP_000109, NP_001108225, NP_001265067
RefSeq mRNA Accession(s)NM_001114753, NM_001278138, NM_000118,
RefSeq Genomic Accession(s)NC_018920, NG_009551, NC_000009
UniProt ID(s)Q96CG0, B7Z6Y5, Q5T9B9, F5GX88, A0A024R878, P17813
UniGene ID(s)Q96CG0, B7Z6Y5, Q5T9B9, F5GX88, A0A024R878, P17813
HGNC ID(s)3349
Cosmic ID(s)ENG
KEGG Gene ID(s)hsa:2022
PharmGKB ID(s)PA27785
General Description of endoglin / CD105.
CD105/endoglin is a Type I membrane glycoprotein located on cell surfaces and is part of the TGF-beta receptor complex. This protein has been found on endothelial cells, activated macrophages, fibroblasts, and smooth-muscle cells. endoglin has a role in the development of the cardiovascular system and in vascular remodeling. Its expression is regulated during heart development. CD105 is highly expressed in endothelial cells during tumor angiogenesis and inflammation, with weak or negative expression in vascular endothelium of normal tissues. Angiogenesis is a promising prognostic marker in a variety of tumors. endoglin is a more specific and sensitive marker for tumor angiogenesis than CD31 or CD34, as it labels only newly-formed blood vessels and may serve as a prognostic marker for Prostate Adenocarcinoma, and cancers of the lung, stomach, breast, and brain.

Human Anti-endoglin / CD105 Antibody Product Attributes

Species: Human
Tested Applications: Western Blot.
Clonality: Monoclonal
Anti-endoglin / CD105 Antibody Clone: ENG/1327
Clone ENG/1327 Host and Isotype: Mouse IgG1
Anti-Human endoglin / CD105 Positive Control Sample: HeLa, A431 and HL-60 cells. Colon.
Cellular Localization of Antibody Cytoplasmic
Buffer and Stabilizer: 10mM PBS with 0.05% BSA and 0.05% Azide
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Recombinant human endoglin protein fragment (aa74-251)
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.

endoglin / CD105 Previously Observed Antibody Staining Patterns

Observed Antibody Staining Data By Tissue Type:

Variations in endoglin / CD105 antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in cells in the glomeruli in kidney. More moderate antibody staining intensity was present in cells in the glomeruli in kidney. Low, but measureable presence of endoglin / CD105 could be seen in. We were unable to detect endoglin / CD105 in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.

Limitations and Warranty

enQuire Bio's endoglin / CD105 Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

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